Navigation Links
Jefferson researchers' discovery may change thinking on how viruses invade the brain

A molecule thought crucial to ferrying the deadly rabies virus into the brain, where it eventually kills, apparently isn’t. The surprising finding, say researchers at Jefferson Medical College in Philadelphia, may change the way scientists think about how central nervous system-attacking viruses such as herpes viruses invade the brain and cause disease.

According to Matthias Schnell, Ph.D., professor of microbiology and immunology at Jefferson Medical College of Thomas Jefferson University, viruses such as rabies must be actively transported to the brain and central nervous system. The LC8 protein was thought to tether viruses to the cellular transport machinery in order to get there.

But Dr. Schnell and his co-workers found that this protein complex is instead a "transcription factor" that plays a role in virus reproduction. "We think that this finding has implications not only for rabies but many viruses that previously were thought to use this complex for transport, such as herpes viruses," he says. They report their results online this week in the journal Proceedings of the National Academy of Sciences.

To understand the role of LC8 in rabies disease in the brain, the team compared a rabies virus strain with the LC8 "binding domain" (where the rabies virus and LC8 protein interact) to a virus lacking it. They showed that in mice that were infected with rabies without the LC8 binding domain, the virus was still able to infect the brain, but did not cause disease. The virus?ability to reproduce was greatly diminished.

"What we found has nothing to do with transport," Dr. Schnell says. "We saw that the virus was weakened if we removed the LC8 binding site and viral replication and transcription were affected. But we didn’t find a difference in the initial viral entry in the central nervous system. We actually saw that the virus replicated better with the binding site than without it. LC8 is a transcription factor that helps t
'"/>

Source:Thomas Jefferson University


Page: 1 2

Related biology news :

1. Jefferson Virologists Coax HIV Out of Hiding
2. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
3. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
4. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
5. Jefferson researchers building a better rabies vaccine
6. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
7. Immune cell communication key to hunting viruses, Jefferson immunologists show
8. Jefferson researchers uncover new way nature turns genes on and off
9. Jefferson scientists find aging gene also protects against prostate cancer development
10. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find
Post Your Comments:
(Date:8/1/2014)... of a new study, including two Simon Fraser ... industry representatives and policymakers must collaborate closely on ... gas development. Viorel Popescu and Maureen Ryan, David ... Sciences department, are among eight international co-authors of ... Ecology and the Environment . , Shale gas ...
(Date:7/31/2014)... A first-of-its-kind study of bigeye tuna movements in the ... the Large Pelagics Research Center at the University of ... cover a wide geographical range with pronounced north-south movements ... favor a high-use area off Cape Hatteras southwest of ... a new approach to study one of the most ...
(Date:7/31/2014)... Census Bureau, Latinos are the largest minority group in ... Approximately one-third of Latinos are obese and are 1.2 ... Whites. , NYU College of Nursing student researcher ... identify the factors that contribute to this problem by ... on food patterns in Latina women recently published in ...
Breaking Biology News(10 mins):Scientists warn time to stop drilling in the dark 2Scientists warn time to stop drilling in the dark 3Study of bigeye tuna in Northwest Atlantic uses new tracking methods 2Study of bigeye tuna in Northwest Atlantic uses new tracking methods 3NYU research looks to combat US Latina immigrant obesity 2
... by which apolipoprotein E, a molecule whose mutation is ... amyloid beta (A?) protein within the brain. The research, ... of the journal Neuron, may lead to a powerful ... the primary characteristics of AD is the accumulation and ...
... The changes in our climate, producing extreme temperatures ... crops − to put it briefly, the crops are ... with Bayer BioScience NV, the Flemish agro-biotech innovation center ... this collaboration, the researchers aim to elucidate the mechanisms ...
... mineral is abundant in desert regions where fresh water is ... are common. Writing in International Journal of Global Environmental ... Team, in Rotterdam, The Netherlands, has hit on the idea ... to release the water locked in gypsum. Fresh water ...
Cached Biology News:Mechanism explains link between apolipoprotein E and Alzheimer's disease 2VIB and Bayer join forces for plant research 2VIB and Bayer join forces for plant research 3Rocky water source 2
(Date:8/1/2014)... August 01, 2014 Once a decision ... cost? This webinar will discuss how to define your ... Join speakers Bob Allen, Senior Director of Facilities Integration ... Engineering at Fluor Industrial Services, and special guest Carrier ... Planning at Amgen, as they provide an examination of ...
(Date:8/1/2014)... Testing the mechanical properties of microtissues ... embryonic development. How and why embryonic stem ... distinct tissues is important because abnormalities can lead ... Melissa Kinney, and Rabbia Saeed worked from the ... to control many aspects of embryo development. ...
(Date:7/31/2014)... Nearly 20,000 medical professionals and healthcare leaders ... Clinical Lab Expo in Chicago ... diagnostic research and technology that will advance medicine and ... of Wednesday, July 30, more than 19,500 attendees had ... Lab Expo, with more than 10,000 of these attendees ...
(Date:7/31/2014)... Hopkins have mapped the sound-processing part of the mouse ... forest and the trees in view. Their imaging technique ... activity within mice, and it enabled the team to ... each other. The results, which represent a step toward ... online July 31 the journal Neuron . , ...
Breaking Biology Technology:Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Study Links Biomechanics and Gene Expression in Stem Cells 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 2Research on Digital Health, Alzheimer's, Ebola Draws Nearly 20,000 Attendees to 2014 AACC Annual Meeting & Clinical Lab Expo 3New mapping approach lets scientists zoom in and out as the brain processes sound 2
... The Case Western Reserve University Biomedical Engineering Department ... benefiting newborns and the aged, the critically ill and ... the future as it celebrates its 40th anniversary, Thursday, ... first universities in the nation to offer graduate and ...
... Pharmaceuticals, Inc. (OTC Bulletin Board: TDLP), a specialty pharmaceutical ... proprietary transdermal delivery platform, today announced that Dr. Juliet ... will present a company overview at two upcoming conferences. ... BIOCOM Investor Conference in San Diego, CA on Monday, ...
... ... Society (PPS), a leading organization dedicated to pricing strategy and pricing research globally and ... attendees of the Vendavo,s Pricing Knowledge Series training programs are now eligible for credit ... ...
Cached Biology Technology:40 Years on the Leading Edge: Case Western Reserve University's Biomedical Engineering Department Commemorates Achievement, Looks to Future 2Transdel Pharmaceuticals to Present at Two Investor Conferences 2Transdel Pharmaceuticals to Present at Two Investor Conferences 3Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 2Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 3Professional Pricing Society Announces Educational Partnership with Vendavo -- "PPS Accepting Vendavo Pricing Knowledge Series Awards to Certified Pricing Professional Program" 4
...
... assay kit measures NOS activity by monitoring ... This assay is simple, sensitive, and specific ... with both crude and purified enzyme preparations. ... for 50 total reactions. Radiolabeled arginine and ...
Human TSLP MAb (Clone 258136)...
Human Complement Component C5a MAb (Clone 295003)...
Biology Products: