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Jefferson Virologists Coax HIV Out of Hiding

to stimulate a group of sub-strains of HIV that are different than those brought out of latency by other agents, such as IL-2, another immune cytokine, or OKT3, a monoclonal antibody. He suspects such strains may be from an unknown viral reservoir in the blood. “IL-7 may teach us something,?he says. “We’re not sure why only these certain strains are affected. We think we’ve found a new population, a new reservoir of HIV that has not been seen before. It’s probably a sub-population of blood cells, lymphocytes not stimulated by IL-2 or OKT3. There could be other reservoirs as well.?Ultimately, he says, the answer to the latency problem may entail using a combination of drugs. “We may need more than one drug to stimulate virus from latency, similar to using HAART to stop replication,?he says, referring to this approach . “We may have to combine IL-2 with IL-7 and other agents to get to the reservoirs of virus.?
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Source:Thomas Jefferson University


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