Navigation Links
Jefferson Virologists Coax HIV Out of Hiding

When researchers came up with the powerful cocktail of anti-HIV drugs known as highly active antiretroviral therapy (HAART), they hoped they had found a way to finally rid the body of the virus. But they were wrong. The virus instead goes into hiding, dormant and practically undetectable in the body ?and impervious to attack. While HAART manages to keep the virus at bay, it’s still quite capable ?given the right opportunity ?of replicating and wreaking havoc on the body’s immune system. Now, virologists at Jefferson Medical College, led by Roger J. Pomerantz, M.D., professor of medicine, biochemistry and molecular pharmacology and director of the Division of Infectious Diseases and Environmental Medicine at Jefferson Medical College of Thomas Jefferson University in Philadelphia, may have found a way to bring HIV out of hiding. They have shown that an immune cell protein called interleukin-7 (IL-7) can rouse the virus better than previously tried agents, making it vulnerable to drugs and the body’s immune system. If the new technique proves its mettle, the work could lead to improved treatments for HIV infection, and might be a step toward complete viral eradication.

The Jefferson team reports its findings January 4, 2005 in the Journal of Clinical Investigation. Dr. Pomerantz, who is director of Jefferson’s Center for Human Virology and Biodefense, and his co-workers took blood cells from HIV-infected patients who had been taking HAART and who had undetectable levels of virus. Using a special technique, they screened the cells with several different drugs to determine what stimulated the latent virus the best. “To our surprise, it was IL-7,?he says. “We don’t know why, but it is the best agent in terms of its ability to stimulate HIV out of latency that we’ve seen in the last 15 years.?They found that the virus was stimulated to higher levels and was activated in more patients than with other compounds. Dr. Pomerantz’s group also discovered that IL-7 appears to stimulate a group of sub-strains of HIV that are different than those brought out of latency by other agents, such as IL-2, another immune cytokine, or OKT3, a monoclonal antibody. He suspects such strains may be from an unknown viral reservoir in the blood. “IL-7 may teach us something,?he says. “We’re not sure why only these certain strains are affected. We think we’ve found a new population, a new reservoir of HIV that has not been seen before. It’s probably a sub-population of blood cells, lymphocytes not stimulated by IL-2 or OKT3. There could be other reservoirs as well.?Ultimately, he says, the answer to the latency problem may entail using a combination of drugs. “We may need more than one drug to stimulate virus from latency, similar to using HAART to stop replication,?he says, referring to this approach . “We may have to combine IL-2 with IL-7 and other agents to get to the reservoirs of virus.?
'"/>

Source:Thomas Jefferson University


Related biology news :

1. Jefferson researchers find nanoparticle shows promise in reducing radiation side effects
2. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
3. Jefferson scientists identify gene defect leading to abnormal skin development and cancer
4. Jefferson researchers building a better rabies vaccine
5. Jefferson scientists identify gene mutation potentially involved in breast cancer initiation
6. Immune cell communication key to hunting viruses, Jefferson immunologists show
7. Jefferson researchers uncover new way nature turns genes on and off
8. Jefferson scientists find aging gene also protects against prostate cancer development
9. Jefferson scientists find high glucose before surgery raises risk of dangerous complications
10. Jefferson researchers discovery may change thinking on how viruses invade the brain
11. Elderly spinal cord injuries increase five-fold in 30 years, Jefferson neurosurgeons find

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
(Date:3/30/2017)... KONG , March 30, 2017 The ... a system for three-dimensional (3D) fingerprint identification by adopting ground breaking ... into a new realm of speed and accuracy for use in ... at an affordable cost. ... ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... The CRISPR-Cas9 system has ... and avoiding the use of exogenous expression plasmids. The simplicity of programming this ... gain-of-function studies. , This complement to loss-of-function studies, such as with RNAi ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... process optimization firm for the life sciences and healthcare industries, announces a presentation ... San Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will ...
Breaking Biology Technology: