Navigation Links
It's not all genetic: Common epigenetic problem doubles cancer risk in mice

k that the genetic mutation will cause a tumor," says postdoctoral fellow Atsushi Kaneda, Ph.D. "Double the risk may not seem like much, but this loss of imprinting is common."

The researchers' mice mirror two situations in people because the double dose of IGF2 was accomplished in two ways. One set of mice, obtained from Shirley Tilghman at Princeton, have a double dose of IGF2 because they are missing another gene, H19, whose sequence overlaps the region that usually shuts off one copy of IGF2. As a result, these mice lack H19 and have double IGF2.

To isolate the effect of the extra IGF2, Rolf Ohlsson at the Uppsala University, Sweden, developed a set of mice missing only the control region for IGF2; their H19 gene was intact. These mice likely mimic the 30 percent of colon cancer patients and 10 percent or so of the human population who have loss of imprinting of IGF2.

Only the Princeton mice have been crossed with the APC mice. Both the Princeton and the Swedish mice have the extra precursor cells in the lining of the colon, suggesting the effect on cancer development would be similar.

Co-author Dan Longo, M.D., of the National Institute on Aging notes that the mice with both double IGF2 and the APC mutation should be a useful animal model to evaluate the impact of colon cancer prevention strategies, including dietary interventions and targeted drugs.


'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. Harmful Bacterium Commonly Found in Poultry May Survive Refrigeration and Frozen Storage Combined
2. Men Estimate Mens Risks Of Common Disorders Higher Than Women Do, And Vice Versa
3. Use of Antibiotics for Acne May Increase Risk of Common Illness
4. Common viruses may cause cancer
5. Common alternative treatment for liver disease is found to be ineffective
6. Common molecular signature identified in solid tumors
7. Common bacteria pirate natural mechanism to get inside cells
8. Commonly used antidepressants may also affect human immune system
9. Common practices at petting zoos put visitors at risk
10. Common enzyme is a key player in DNA repair
11. Common molecular signature identified in solid tumors
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: not all genetic Common epigenetic problem doubles cancer risk mice

(Date:5/22/2013)... Legionella pneumophila bacteria is responsible for legionellosis, an ... to infect us, this pathogen has developed a complex ... in our cells, thus avoiding these acting against the ... research centre, CIC bioGUNE, in which teams from the ... the National Supercomputation Centre in Barcelona (BSC) have also ...
(Date:5/22/2013)... screening for prostate cancer could become as easy for ... to UC Irvine research published today in the ... more than a decade of work, UC Irvine chemists ... markers for prostate cancer in urine, meaning that the ... and at dramatically lower cost. The same technology could ...
(Date:5/22/2013)... May 22, 2013. Plastic additives known as phthalates ... everywhere: They turn up in flooring, plastic cups, ... the Centers for Disease Control and Preventionthe bodies ... have come under increasing scrutiny. A growing collection ... can leech from packaging and mix with food) ...
Breaking Biology News(10 mins):Mechanism discovered which aids Legionella to camouflage itself in the organism 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 2UCI chemists devise inexpensive, accurate way to detect prostate cancer 3Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2
... some transplant patients may arise because cells that normally serve ... study suggests. , The cancer is caused by Epstein-Barr ... of Americans but is ordinarily kept under control by the ... immune system is suppressed to prevent rejection of a transplanted ...
... wild rodents with their laboratory counterparts, researchers at Duke ... to explain why people in industrialized societies that greatly ... diseases than do people in less developed societies in ... critical. , The prevailing hypothesis concerning the development of ...
... important mechanism that regulates how many new cells are ... published in the latest issue of the prestigious scientific ... drugs for things like neurological disorders and anaemia," says ... body, old cells are continually being replaced by new. ...
Cached Biology News:Failure of 'scout cells' may lead to cancer in transplant patients 2Failure of 'scout cells' may lead to cancer in transplant patients 3Wild vs. lab rodent comparison supports hygiene hypothesis 2Wild vs. lab rodent comparison supports hygiene hypothesis 3Wild vs. lab rodent comparison supports hygiene hypothesis 4New stem-cell findings can help the body to cure itself 2
(Date:5/24/2013)... May 24, 2013 Many factors impact ... uptake or efflux transporters at the blood-tissue barrier. Even ... to unbound fractions in the tissue rather than the ... disposition challenges is required to guide lead optimization, predict ... any species-dependent variables that may impact the likely human ...
(Date:5/23/2013)... their baby stopped breathing, his collapsed bronchus blocking the ... Bryan Gionfriddo watched helplessly, just praying that somehow the ... said he had a good chance of not leaving ... 20-month-old son, Kaiba. "At that point, we were desperate. ... run with it." , They found hope at the ...
(Date:5/23/2013)... Patheon Inc ., a leading provider ... pharmaceutical industry, will host a complimentary webinar on “Cleaning ... Tuesday, June 4, 2013 at 11 a.m. Eastern Standard ... comply with regulations for cleaning validation. Many companies ... and little evaluation of risk. Some companies have ...
(Date:5/23/2013)... Calif. , May 23, 2013 ... a strategic alliance with DAK Renewable Research to ... corn oil yield. VG Energy is a majority ... Pink: VGLS). VG Energy,s exclusively licensed ... increase the oil yield in plants, possessing a ...
Breaking Biology Technology:DMPK for Targeted Tissue Delivery: Solutions for the Most Challenging Part of Outsourcing, New Life Science Webinar Hosted by Xtalks 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 2Baby's life saved with groundbreaking 3-D printed device that restored his breathing 3Patheon to Present on “Cleaning Validation: Science, Risk and Novel Approaches to Testing” 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 2VG Energy Enters into a Strategic Alliance with DAK Renewable Research for LipidMax Field Trials 3
... Renaissance Learning Inc., a provider of learning information systems ... net income for the quarter ending March 31 was ... an increase of 8.8 percent. , ,The company also ... payable June 1, 2005, to shareholders of record as ...
... the years is a funny thing. , ,When Midwest ... were mostly talking about reaching out to their friends ... In other words, to most Midwest tech networkers, "networking" ... has taken on a new meaning. People still talk ...
... newly forming venture capital firm, hopes to make ... in information technology companies. Also, state Assembly Republicans ... companies doing studies that require destroying embryos, and ... statewide network. Original air date: Saturday, April 16, ...
Cached Biology Technology:Off-the-grid networking can help you cut past chit-chat 2Off-the-grid networking can help you cut past chit-chat 3Off-the-grid networking can help you cut past chit-chat 4
iEMS Thermal Microplate Holder...
...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... PTOs are internucleotide modifications, where ... is replaced by a sulphur atom. This ... PTOs are available as Full-PTOs ... Oligonucleotides with thio-caps Several ...
Biology Products: