Navigation Links
Iron exporter revealed that may explain common human disorder

The first direct evidence that a single protein is critical in the cellular export of iron may help to explain human hemochromatosis, researchers report in the March issue of Cell Metabolism.

Hemochromatosis--which affects one in every 200 to 300 people in Western populations --causes tissues of the body to become overloaded with iron. Left untreated, the hereditary disease can lead to organ failure.

The new work, led by researchers at the Children's Hospital Boston and Harvard Medical School, finds that the protein ferroportin is the major, if not the only, iron exporter that functions in key sites of iron absorption and release in the body. The findings suggest that the iron accumulation seen in those with hemochromatosis may stem from a loss of control over iron export through ferroportin, the researchers said.

"Iron is essential in the body and abundant in the environment, but it's also very reactive and damaging when in excess," said Nancy Andrews, senior author of the study. "Mammals have therefore evolved mechanisms to get enough iron from the diet, but not too much."

Iron is an essential ingredient of hemoglobin, the protein molecule in red blood cells that carries oxygen from the lungs to the body's tissues. Unlike other metals, iron cannot be eliminated through the liver or kidneys, Andrews explained. Iron balance is maintained instead through the complex regulation of tissues that transport, store, and utilize iron.

Mammals, including humans, initially obtain iron from their mothers. After birth, the intestine absorbs dietary iron and releases it into the bloodstream where developing red blood cells incorporate the iron into hemoglobin. When red blood cells die, macrophage cells consume them and recycle the iron they contain. Macrophages and liver cells also store any excess iron.

Earlier work had identified a single protein that imports iron into cells. However, the evidence for ferroportin's role in exporti
'"/>

Source:Cell Press


Page: 1 2 3

Related biology news :

1. Elusive HIV shape change revealed; Key clue to how virus infects cells
2. Timing is everything: First step in protein building revealed
3. Vitamin As paradoxical role in influencing symmetry during embryonic development revealed
4. Malaria mechanism revealed
5. An essential regulator of body weight revealed
6. Underlying cause of massive pinyon pine die-off revealed
7. Shorter colds, milder flu may follow from newly revealed immune mechanism
8. Image of myosin-actin interaction revealed in cover story of Molecular Cell
9. Mechanism for memory revealed in neurons of electric fish
10. Ticks, flukes, and genomics: Emerging pathogens revealed
11. Healing honey: The sweet evidence revealed
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Iron exporter revealed that may explain common human disorder

(Date:9/18/2014)... researchers from McGill University and the Quebec government ... ,microbeads, Canadian Journal of Fisheries and Aquatic ... cosmetics, household cleansers, or industrial cleansers, to which ... their small size and buoyancy, they may readily ... a global contaminant in the world,s oceans, but ...
(Date:9/18/2014)... MADISON, Wis. No matter how many times ... as social, communicating creatures. , But by ... single-celled organisms radically alter their behavior to suit ... many of them are present, and act accordingly. ... the millions, it may change from innocuous to ...
(Date:9/18/2014)... spoken language is unique to humans. "The genetic changes ... human evolution to make this possible are largely unknown, ... have," says Wolfgang Enard, Professor of Anthropology and Human ... molecular biological basis of language Enard has now taken ... study, undertaken in collaboration with scientists at several universities, ...
Breaking Biology News(10 mins):Microplastic pollution discovered in St. Lawrence River sediments 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... In the minds of many, Miscanthus x giganteus ... for lignocellulosic bioenergy production. But researchers believe "putting all their ... at the University of Illinois recently reported the first natural ... in Japan. "If M. x giganteus ...
... announced the winners of its second annual CPOW travel ... at the Baltimore Convention Center in Baltimore, Maryland, March ... for Women, has initiated these travel fellowships to increase ... at the Meeting. The recipients of this competitive ...
... The Biophysical Society has announced the winner of ... 55th Annual Meeting at the Baltimore Convention Center in ... meant to encourage participation at the Biophysical Society Annual ... will be honored at a reception on Saturday March ...
Cached Biology News:New Miscanthus hybrid discovery in Japan could open doors for biofuel industry 2New Miscanthus hybrid discovery in Japan could open doors for biofuel industry 3Biophysical Society announces winners of 2011 CPOW Travel Awards 2Biophysical Society announces winners of 2011 Minority Travel Awards 2
(Date:9/19/2014)... 2014 Barnhardt Manufacturing Company ... its Organic Cotton . The USDA Certified Biobased ... biobased ingredients meets or exceeds levels set by USDA. ... whole or in significant part of agricultural, forestry, or ... Organic cotton to be immediately identified as a USDA ...
(Date:9/19/2014)... , September 19, 2014 , ... European Society for Paediatric Endocrinology (ESPE) Meeting  ... and medical research in the field of growth  , ... Darmstadt, Germany , today announced the ... for 2014. The awards were announced during a Satellite ...
(Date:9/18/2014)... TX (PRWEB) September 18, 2014 ... integrated urological and interventional radiology products and services, ... known as cryotherapy and cryoablation) versus external beam ... Section of the American Urological Association (MAAUA) Annual ... , "Comparing Relative Effectiveness of Cryosurgery and External ...
(Date:9/18/2014)... A novel robotic system that can operate inside ... tested as part of a biomedical research partnership program ... aim of determining if the robot, in conjunction with ... more accurate, less costly, and less discomforting for the ... deliver prostate cancer therapies with greater precision. , Developed ...
Breaking Biology Technology:Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6
... Inc. (Nasdaq: ONXX ) today announced that ... Conference on Thursday, June 26, at,10:45 a.m. Eastern ... of,the presentation on our website at:, ... log on 15 minutes early in order to,register ...
... June 19 A new chemical fertility control,technology ... on rice production in developing countries is being ... Diego, California from the 17th,through the 20th of ... is developing a technology that will target the ...
... AstraZeneca,s CEO to be Deposed in London on Friday, ... Weitz & Luxenberg, PC, one of the,leading plaintiffs, litigation ... giant AstraZeneca on behalf of a New York City ... AstraZeneca,s drug Seroquel. The plaintiff, EMT Ernest Armstead, was ...
Cached Biology Technology:Arizona-Based SenesTech, Inc., Partners With Australia to Stop Starvation Due to Rice Shortages 2Arizona-Based SenesTech, Inc., Partners With Australia to Stop Starvation Due to Rice Shortages 3Weitz & Luxenberg Files Seroquel Diabetes Lawsuit Against AstraZeneca 2