Navigation Links
Intrinsic eye protein halts angiogenesis

Dr. Jayakrishna Ambati, of the University of Kentucky, and Dr. Balamurali Ambati, of the Medical College of Georgia, have jointly published a paper in the journal Nature detailing major research discoveries in corneal avascularity and angiogenesis.

In their paper published online Oct. 18, 2006, the researchers present evidence that unravels the mystery of how a healthy cornea remains clear and free of blood vessels, which is essential for vision, and raises questions about the implications for anti-angiogenesis treatments in macular degeneration, cancer and other diseases.

Angiogenesis, or blood vessel growth, is what propels the growth of cancerous tumors and blinding conditions like macular degeneration. Because healthy corneas are avascular (free of blood vessels) they have long been the testing grounds for anti-angiogenesis drugs intended to treat conditions in other areas of the body.

The Ambatis, brothers who are both engaged in the clinical practice of ophthalmology as well as in basic research, discovered that a protein known as SFLT-1 is singularly responsible for warding off blood vessel growth in the cornea. When SFLT-1 is deactivated, angiogenesis begins and blood vessels spontaneously invade the cornea. They studied a wide variety of mammals and confirmed the effect in each species including humans.

"The millenia-old mystery of corneal avascularity has been the subject of serious scientific inquiry for 50 years. The significance of this publication is that we have now identified a single protein responsible for this phenomenon, and it can be applied to other areas of the body as well," said Jayakrishna Ambati.

Previously, scientists had experimented with various ways to clear blood vessel growth in corneal tissue ?a condition that often occurs due to herpetic infections of the eye, chemical burns, traumatic injury or surgery such as corneal transplantation.

"The standard paradigm has been the cornea i s avascular because it has lots of anti-angiogenic molecules and it does," Balamurali Ambati said. "But knockdown of any of the other molecules does not cause blood vessels to enter the cornea. Knocking down SFLT-1 allows angiogenesis to take hold."

The next step, according to the researchers, is to test SFLT-1 in other areas of the body, encouraging tissues to produce the protein on their own.

"We want to know what it is in the cornea that produces so much of this protein which inhibits angiogenesis. With that knowledge we will be closer to fighting the growth of everything from vision-obscuring blood vessels in the eye to cancers," said Jayakrishna.


'"/>

Source:University of Kentucky


Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/22/2017)... Vigilant Solutions , a vehicle location ... announced today the appointment of retired FBI special agent ... business development. Mr. Sheridan brings more than ... focus on the aviation transportation sector, to his new ... Sheridan served as the Aviation Liaison Agent Coordinator (ALAC) ...
(Date:3/13/2017)... Future of security: Biometric Face Matching software  ... ... Matching enables to match face pictures against each other or against large databases. ... Systems) ... the fastest software for biometric Face Matching on the market. The speed is ...
(Date:3/7/2017)... CITY , March 7, 2017   HireVue ... help top global companies identify the best talent, faster, ... as Chief Sales Officer (CSO) and Diana Kucer ... appointments round out a seasoned executive team poised to drive ... beyond, building on a year of record bookings in ...
Breaking Biology News(10 mins):
(Date:3/27/2017)... (PRWEB) , ... March 27, 2017 , ... ... method to engineer scalable and customizable vascular grafts in JoVE’s Video Journal, the ... lead to new and improved ways of treating coronary artery disease (CAD). Lam ...
(Date:3/24/2017)... 2017 MiMedx Group, Inc. (NASDAQ: MDXG), the ... tissue allografts and patent-protected processes to develop and market ... announced today  that it will present at the Needham ... NY.  Parker H. "Pete" Petit, Chairman and CEO, ... M. Cashman , EVP and Chief Commercialization Officer, and ...
(Date:3/24/2017)... March 24, 2017 On Thursday, ... session at 5,817.69, down 0.07%; the Dow Jones Industrial ... the S&P 500 closed at 2,345.96, marginally dropping 0.11%. ... closed in green, 4 sectors finished in red, and ... Stock-Callers.com has initiated reports coverage on the following Biotechnology ...
(Date:3/23/2017)... ... March 23, 2017 , ... Lajollacooks4u is proud to announce it has become the ... corporate cooking challenges for companies around the world, such as Illumina, HP and Qualcomm, and ... reason for its increasing popularity is due to its new team building format, a way ...
Breaking Biology Technology: