Navigation Links
Intrinsic eye protein halts angiogenesis

Dr. Jayakrishna Ambati, of the University of Kentucky, and Dr. Balamurali Ambati, of the Medical College of Georgia, have jointly published a paper in the journal Nature detailing major research discoveries in corneal avascularity and angiogenesis.

In their paper published online Oct. 18, 2006, the researchers present evidence that unravels the mystery of how a healthy cornea remains clear and free of blood vessels, which is essential for vision, and raises questions about the implications for anti-angiogenesis treatments in macular degeneration, cancer and other diseases.

Angiogenesis, or blood vessel growth, is what propels the growth of cancerous tumors and blinding conditions like macular degeneration. Because healthy corneas are avascular (free of blood vessels) they have long been the testing grounds for anti-angiogenesis drugs intended to treat conditions in other areas of the body.

The Ambatis, brothers who are both engaged in the clinical practice of ophthalmology as well as in basic research, discovered that a protein known as SFLT-1 is singularly responsible for warding off blood vessel growth in the cornea. When SFLT-1 is deactivated, angiogenesis begins and blood vessels spontaneously invade the cornea. They studied a wide variety of mammals and confirmed the effect in each species including humans.

"The millenia-old mystery of corneal avascularity has been the subject of serious scientific inquiry for 50 years. The significance of this publication is that we have now identified a single protein responsible for this phenomenon, and it can be applied to other areas of the body as well," said Jayakrishna Ambati.

Previously, scientists had experimented with various ways to clear blood vessel growth in corneal tissue ?a condition that often occurs due to herpetic infections of the eye, chemical burns, traumatic injury or surgery such as corneal transplantation.

"The standard paradigm has been the cornea i s avascular because it has lots of anti-angiogenic molecules and it does," Balamurali Ambati said. "But knockdown of any of the other molecules does not cause blood vessels to enter the cornea. Knocking down SFLT-1 allows angiogenesis to take hold."

The next step, according to the researchers, is to test SFLT-1 in other areas of the body, encouraging tissues to produce the protein on their own.

"We want to know what it is in the cornea that produces so much of this protein which inhibits angiogenesis. With that knowledge we will be closer to fighting the growth of everything from vision-obscuring blood vessels in the eye to cancers," said Jayakrishna.


'"/>

Source:University of Kentucky


Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... Research and Markets has announced the addition of the ... ... to grow at a CAGR of 30.37% during the period 2017-2021. ... been prepared based on an in-depth market analysis with inputs from ... prospects over the coming years. The report also includes a discussion ...
(Date:4/11/2017)... April 11, 2017 NXT-ID, Inc. (NASDAQ: ... company, announces the appointment of independent Directors Mr. Robin ... its Board of Directors, furthering the company,s corporate governance and ... Gino Pereira ... look forward to their guidance and benefiting from their considerable ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... TX (PRWEB) , ... October 11, 2017 , ... ... August compared the implantation and pregnancy rates in frozen and fresh in ... contribution of progesterone and maternal age to IVF success. , After comparing the ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... FirstHand program has won a US2020 STEM Mentoring Award. Representatives of the FirstHand ... Excellence in Volunteer Experience from US2020. , US2020’s mission is to change the ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... optimization firm for the life sciences and healthcare industries, announces a presentation by ... Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present ...
Breaking Biology Technology: