Navigation Links
International Team Determines Geographic Origin of Leprosy

Leprosy likely originated in East Africa and spread to Asia and Europe before being imported into West Africa by explorers, report scientists in this week's issue of Science. The findings enrich the historical understanding of leprosy's global migration and contradict a commonly held view that leprosy spread to West Africa directly from East Africa, say the researchers.

The international team of investigators, who identified rare genetic variations among strains of the bacterium that causes leprosy, included Patrick J. Brennan, Ph.D., of Colorado State University in Fort Collins. Dr. Brennan is a grantee of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

"Using modern genetic techniques, these researchers uncovered clues to the origin of a disease that, since ancient times, has been one of the most stigmatizing," notes NIAID Director Anthony S. Fauci, M.D. "Their findings may help public health officials better track and treat leprosy, which remains a significant problem in some parts of the world today."

The research team included scientists from institutions in the United States, France and seven other countries. Led by Stewart T. Cole, Ph.D., of the Institut Pasteur in Paris, the investigators scanned the genetic material of Mycobacterium leprae, the bacterium that causes leprosy, for tiny variations known as single nucleotide polymorphisms (SNPs). SNPs, pronounced "snips," are variations in a single "letter" of DNA's four-letter code. Scientists can use SNPs to trace the lineage of an organism, in this case M. leprae, and to develop a picture of how leprosy spread from its point of origin. The team looked for SNPs in 171 clinical specimens of M. leprae taken from people infected with the bacterium. The specimens came from 21 countries representing five continents.

Four types of SNP appeared in the samples, but their distribution was not random. Instead, the investigators
'"/>

Source:NIH


Page: 1 2

Related biology news :

1. International trial of two microbicides begins
2. International HapMap consortium expands mapping effort
3. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
4. International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy
5. International team analyzes human genetic variation in key immune region
6. Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation
7. New Look at DNA Hints at Origin of UV Damage
8. Stem Cells Found In Cerebellum; Possible Cell of Origin for Childhood Brain Tumors
9. Researchers Discover Ancient Origins Of Tuberculosis-causing Bacteria
10. Origin of inherited pain disorder pinpointed
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: International Team Determines Geographic Origin Leprosy

(Date:8/21/2014)... previously unknown process for harvesting energy and producing oxygen ... State University scientist has discovered. The discovery lays the ... harvesting energy from the Sun, and understanding dense blooms ... lakes worldwide. A paper describing the discovery will be ... the journal Science on 21 August 2014. ...
(Date:8/21/2014)... A ubiquitous skin fungus linked to dandruff, eczema and ... tracked to even further global reachesincluding Hawaiian coral reefs ... sea vents. , A review in the scientific journal ... distribution of the fungi of the genus Malassezia ... environmental sequencing datasets from around the world. , University ...
(Date:8/21/2014)... intake, health and quality of life of older adults ... the University of Waterloo receiving close to $1.5 million ... (CIHR). , Professor Heather Keller, of the Faculty ... research chair in nutrition and aging, will receive $979,000 ... in long-term care homes are poorly nourished. The project ...
Breaking Biology News(10 mins):Hot-spring bacteria reveal ability to use far-red light for photosynthesis 2Hot-spring bacteria reveal ability to use far-red light for photosynthesis 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2Grants will fund landmark aging research at Waterloo 2
... will take place on the campus of the Abdus ... the Academy,s secretariat. TWAS,s new executive director, Romain Murenzi, ... of TWAS; Fernando Quevedo, director of ICTP; Immacolata Pannone, ... TWAS President, will highlight the opening ceremony. The morning ...
... 15, 2011   DigitalPersona, Inc. ... protection solutions, today announced at the CARTES & ... company has open sourced its new MINEX-certified FingerJetFX™ ... (OSE), is free, portable software that device manufacturers ...
... FRANCISCO, CANovember 15, 2011The American Heart Association will ... Emeritus Robert Mahley, MD, PhD, with the 2011 ... on one of Gladstone,s founding cardiovascular scientists. ... that the American Heart Association can give a ...
Cached Biology News:TWAS 22nd General Meeting in Trieste 2DigitalPersona Open Sources New FingerJetFX Biometrics Technology for Mobile Devices, PCs and Servers 2DigitalPersona Open Sources New FingerJetFX Biometrics Technology for Mobile Devices, PCs and Servers 3Gladstone founder receives American Heart Association Distinguished Scientist Award 2
(Date:8/22/2014)... are intensively investigated for application as catalysts, ... and components in photonics and molecular electronics. ... for understanding physical and chemical properties, has ... USA, have demonstrated that high-resolution electron microscopy ... structure in which all gold atoms are ...
(Date:8/22/2014)... The AMA is pleased to share with the ... Alaska Governor Sean Parnell has signed House Bill 255 ... of Unmanned Aircraft Systems and the continuation of the ... it is, “An Act relating to unmanned aircraft systems; ... system.” It defines State of Alaska laws regarding data ...
(Date:8/21/2014)... 21, 2014 DNA vaccine pioneer ... its development of JRC-LAMP-vax, an innovative and safe potential ... IC studies began this month in Hawaii, moving the ... , The Japanese red cedar releases pollen that causes ... Mountain Cedar pollen wreaks similar havoc in Colorado, New ...
(Date:8/21/2014)... 2014 His Majesty Willem-Alexander, King of ... Court of His Majesty Willem-Alexander, King of the Netherlands, ... Opening of POET-DSM Advanced Biofuels’ Project LIBERTY cellulosic ethanol ... The King will take part in the Grand Opening ... 11 a.m.-12:20 p.m. and tour the plant. POET-DSM is ...
Breaking Biology Technology:A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2State of Alaska Signs Unmanned Aircraft Systems Bill 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 2Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 3Relief for Allergy Sufferers Finally in Sight: Immunomic Therapeutics Closes in on Treatment for Hay Fever in Japan, U.S. 4His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 2His Majesty Willem-Alexander, King of the Netherlands, to Attend Project LIBERTY opening 3
... communications system. Image courtesy of GE Healthcare. Wisconsin ... include $10 million for a grant and loan program ... systems. , ,"I am committed to ensuring that all ... why I am pleased to unveil a proposal of ...
... and Minnesota students will get a one-of-a-kind experience today ... the International Space Station Expedition 10 crew. , ,The ... EST today at Crossroads Elementary School, St. Paul, Minn. ... Leroy Chiao and Flight Engineer Salizhan Sharipov. Nearly 700 ...
... human embryos. , ,This weeks announcement out of Kings ... the sheep, has been granted a license by the British ... hopes among disease sufferers, scientists and advocacy groups for a ... (ALS). , ,These diseases could be addressed through research on ...
Cached Biology Technology:Doyle proposes $10M to expand use of electronic medical records 2Doyle proposes $10M to expand use of electronic medical records 3Human cloning plans get blessing from British government 2Human cloning plans get blessing from British government 3
Hybridization cassette for one slide...
Request Info...
Contains 0.2 g/L EDTA4Na in phosphate-buffered saline....
Quantibody Human Angiogenesis Array 1 (1 slide) Class: Quantitative Antibody Arrays Product Group: Antibody Array...
Biology Products: