Navigation Links
International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

afaa El-Sadr, M.D., M.P.H., M.P.A., of the Harlem Hospital Center and Columbia University in New York City, one of the principal investigators for the trial. "We were surprised to learn that in the short term, episodic antiretroviral therapy carries such an increased risk without evidence of sparing patients the known side effects associated with ART."

The University of Minnesota's James Neaton, Ph.D., another principal investigator and chief biostatistician for the trial, notes, "The SMART trial reached a conclusion much earlier than we expected. That is the significant value and potential power of conducting such a large trial."

The SMART study was coordinated by four international centers: the Medical Research Council Clinical Trials Unit in London; the Copenhagen HIV Program in Denmark; the National Centre in HIV Epidemiology and Clinical Research at the University of New South Wales in Sydney, Australia; and the Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA) in Washington, DC. The statistical and data management center was based at the University of Minnesota in Minneapolis.

Fred Gordin, M.D., of the VA Medical Center in Washington, DC, the CPCRA director, says, "It is gratifying when the fruits of such hard work by so many individuals and the faith put in the investigators by the volunteers results in important data concerning the use of ART."

David Cooper, M.D., D.Sc., of the National Centre in HIV Epidemiology and Clinical Research at the University of New South Wales, the Sydney international coordinating center director, notes, "SMART is an example of how a large group of investigators around the world can work together to obtain an answer to an important HIV treatment question."

Further information concerning the study findings can be found in a Questions and Answers document below. An earlier NIAID news release describing the initiation of the SMART trial can be viewed at

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3 4

Related biology news :

1. International trial of two microbicides begins
2. International HapMap consortium expands mapping effort
3. Solutions that reduce death of marine life reeled in by International Smart Gear Competition
4. International Team Determines Geographic Origin of Leprosy
5. International team analyzes human genetic variation in key immune region
6. New therapy for HIV/AIDS eliminates needles and excessive toxicity
7. South Africa still debating how to tackle HIV/AIDS when 5 million are infected
8. AIDS expert says global strategy needed to combat feminization of HIV/AIDS
9. Progress on HIV/AIDS significant but insufficient
10. HIV/AIDS rates in Tijuana, Mexico increasing at alarming rate
11. Study defines effective microbicide design for HIV/AIDS prevention
Post Your Comments:
(Date:7/24/2014)... Invertebrate numbers have decreased by 45% on average over ... doubled, reports a study on the impact of humans ... the enormous benefits invertebrates such as insects, spiders, crustaceans, ... pollination and pest control for crops, decomposition for nutrient ... published in Science and led by UCL, ...
(Date:7/24/2014)... Imagine a smog-free Los Angeles, where electric cars ply ... run on heat from beneath the earth, from howling ... new Stanford study finds that it is technically and ... one powered by clean, renewable energy. Published in ... sustainable, inexpensive and reliable energy supply in California that ...
(Date:7/24/2014)... has its own microbial terroir, meaning the microbial populations ... in the product, creating the final flavor according to ... Applied and Environmental Microbiology . This is the first ... sake brewery. , Many sake makers inoculate with ... Mills of the University of California, Davis, but he ...
Breaking Biology News(10 mins):Invertebrate numbers nearly halve as human population doubles 2Invertebrate numbers nearly halve as human population doubles 3Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4The microbes make the sake brewery 2
... found that winter precipitation such as rain and snow ... 100 years. Similar increases in heavy rainfall have now ... autumn. A previously reported reduction in heavy summer rainfall ... the last decade indicating a return to more typical amounts ...
... in Civil and Environmental Engineering at MIT reveal that ... lies in the specific geometric configuration of structural proteins, ... work cooperatively to resist force and dissipate energy. ... as steel, even though the glue of hydrogen bonds ...
... change, stem cell researchScientists are frequently called upon ... that pervade the daily news headlines, yet most ... of the television studio or leading questions from ... American Institute of Biological Sciences (AIBS), "Communicating Science: ...
Cached Biology News:Heavy rainfall on the increase 2Protein's strength lies in h-bond cooperation 2Protein's strength lies in h-bond cooperation 3Priming scientists for successful media interviews 2
(Date:7/25/2014)... "Ischemic Stroke and Cerebral Stroke Global ... the Ischemic Stroke and Cerebral Stroke clinical trial ... relating to the clinical trials on Ischemic Stroke ... Stroke Research Report 2014 at: http://www.marketresearchreports.biz/analysis/213207 ... numbers and their recruitment status as per the ...
(Date:7/25/2014)... -- Research and Markets  has announced the ... report to their offering. ... Metabonomics is the scientific study of chemical processes ... technique that is being widely used in biology, ... molecules that are present in blood, urine, and ...
(Date:7/25/2014)... California (PRWEB) July 25, 2014 Lawrence ... named to Thomson Reuters list of " The World's ... are part of the 3,000 researchers who were identified ... to recognize those who published the highest-impact work (2002-2012 ... research papers on combustion modeling . , "This ...
(Date:7/25/2014)... Sinovac Biotech Ltd. (Nasdaq: SVA ), a leading ... today announced that it will release its unaudited financial results ... close on Thursday, August 14, 2014 EDT. The Company will ... Friday, August 15, 2014, at 8:00 a.m. EDT (Friday, August ... the Company,s financial results and provide an update on recent ...
Breaking Biology Technology:Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2Scientists Burst onto Influential List for Combustion Research 2Scientists Burst onto Influential List for Combustion Research 3Scientists Burst onto Influential List for Combustion Research 4Sinovac to Host Conference Call to Report Second Quarter 2014 Unaudited Financial Results 2
... rapidly emerging advanced biofuels industry urged congressional leaders today ... the commercialization of new biofuel production technologies. ... Members of the House Ways and Means and Senate ... pressed for a five year extension of the Cellulosic ...
... Corp. (NASDAQ: BSTC ), a biopharmaceutical company ... in the U.S. and XIAPEX® in Europe and Eurasia, ... at the following upcoming investor conferences during the month ... Company 32nd Annual Health Care Conference (Boston, MA) ...
... Institute for Biologically Inspired Engineering at Harvard University and ... magnetic sensitivity in an organism that is not naturally ... magnetize a variety of different cell types in medical, ... today,s issue of PLoS Biology . Magnetic ...
Cached Biology Technology:Global Leaders in Advanced Biofuels Industry Urge Congressional Leaders to Extend Critical Tax Provisions 2BioSpecifics Technologies Corp. Announces Presentations at Two Upcoming Investor Conferences in March 2New 'magnetic yeast' marks step toward harnessing Nature's magnetic capabilities 2New 'magnetic yeast' marks step toward harnessing Nature's magnetic capabilities 3
... Plasma Immunodepletion Kit specifically removes 20 of ... or serum in preparation for further proteomics ... the plasma proteome whether you use one- ... or go straight to mass spectrometry. This ...
... a direct antibiotic-based selection ... Recombinant selection depends solely ... the need for costly ... and inexpensive process provides ...
... can perform many sophisticated DNA analysis and protein ... than just another sequence analysis product. Imagine having ... analyses to be performed each time you have ... sheets which specify exactly how your output will ...
... is the first fully automated proteomics workcell. ... operations with complete data tracking. It automates ... picking through final protein expression and measurement. ... delivering a plate to any of its ...
Biology Products: