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Interfering RNA silences genes in 'slippery' immune cells

to self-destruct, thus eliminating a hiding place for the virus," said Dr. Finkel.

"More broadly," she added, "the technique could theoretically be directed against other immune-related diseases, by silencing harmful genes active in T cells."

Dr. Finkel's co-authors, all from The Children's Hospital of Philadelphia, were Jiyi Yin, Ph.D., Zhengyu Ma, Nithianandan Selliah, Ph.D., Debra K. Shivers and Randy Q. Cron, M.D., Ph.D. National Institutes of Health grants supported the research, along with support from the University of Pennsylvania Center for AIDS Research and the University's Cancer Center, the Bender Foundation, the Joseph Lee Hollander Chair at The Children's Hospital of Philadelphia, and the W. W. Smith Charitable Trust.

"Effective Gene Suppression Using Small Interfering RNA in Hard-to-Transfect Human T Cells." Journal of Immunological Methods. In press, published online March 24, 2006.


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Source:Children's Hospital of Philadelphia


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