Navigation Links
Intelligently designed molecular evolution

Evolutionary paths to new therapeutic drugs, as well as a wide assortment of other enzyme products, have been created through, of all things, intelligent design. A team of researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley have developed a technique in which the evolution of an important class of proteins is steered towards a desired outcome.

"We've taken enzymes that are promiscuous, meaning they have the capacity to evolve along many different functional lines, and trained them to become specialists," said chemical engineer Jay Keasling, who led this study.

"This technology could be used by pharmaceutical manufacturers in the future to create specific enzyme products."

Keasling is director of Berkeley Lab's Physical Biosciences Division, and a professor of chemical engineering with UC Berkeley's Chemical Engineering Department. Collaborating with him on this project were his graduate student, Yasuo Yoshikuni, and Thomas Ferrin, a professor of pharmaceutical chemistry and biopharmaceutical sciences at UC San Francisco.

The results of this study were reported in the February 22, 2006, on-line edition of the journal Nature.

According to the theory of divergent molecular evolution, primordial enzymes and other proteins started out as "promiscuous" so that primitive organisms would be better able to adapt to their environment. Driven by selective pressures, these promiscuous enzymes and other proteins evolved along divergent lines to acquire the specialized functions needed by a host organism to survive.

"This process is highly dependent on the fact that the functions of promiscuous proteins can be altered with just a small number of amino acid substitutions, a property known as plasticity," said Keasling. "It was our contention that the application of the theory of divergent molecular evolution to promiscuous enzymes would enable us to desi
'"/>

Source:DOE/Lawrence Berkeley National Laboratory


Page: 1 2 3

Related biology news :

1. Medical molecules designed to respond to visible light that can penetrate tissue
2. Redesigned protein accelerates blood clotting
3. New implanted contacts designed to fix nearsightedness
4. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
5. Source of molecular triggers in cutaneous T cell lymphoma identified
6. Plants, animals share molecular growth mechanisms
7. NYU researchers simulate molecular biological clock
8. Scientists reveal molecular secrets of the malaria parasite
9. Scientists identify molecular events that drive cell senescence
10. Researchers discover molecular mechanism that desensitizes us to cold
11. Findings have implications for tracking disease, drugs at the molecular level
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Intelligently designed molecular evolution

(Date:9/15/2014)... simple, mechanical solution to avoid chromosome sorting errors, ... Express. , This natural safeguard ... to infertility, miscarriage, or congenital conditions. , ... but what exactly goes wrong is often not ... Center for Cell Biology at the University of ...
(Date:9/15/2014)... When this week,s print issue of the journal ... up from New Mexico, Montana and even the Netherlands, ... more and more the norm in these connected times. ... it will produce innovations in biology, medicine, biotechnology and ... this scientist talked with that one, that one knew ...
(Date:9/15/2014)... assistant professor in the Department of Science and Technology ... Human Sciences at Virginia Tech, has won a 2014 ... study the prospects and problems of creating a global ... Japan,s Fukushima I Nuclear Power Plant in March 2011 ... viewed nuclear emergencies, Schmid said. Three of the plant,s ...
Breaking Biology News(10 mins):Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Collaboration drives achievement in protein structure research 2'Nuclear disasters don't respect national boundaries' 2
... GAINESVILLE, Fla. --- Imagine a Web site like Facebook, ... post quizzes like "What ,80s song are you?" scientists ... few mouse clicks separating them from information needed for ... $12.2 million National Center for Research Resources grant awarded ...
... , REDWOOD CITY, Calif., Oct. 20 DigitalPersona, ... solutions, today announced that WAND Corporation, a leading ... has integrated DigitalPersona technology into their NextGen POS ... now use fingerprint biometrics to boost cashier accountability ...
... a new approach to prepare ancient DNA with a ... an MU animal scientist, along with a team of ... tree" for cows and other ruminants, going back as ... allow scientists to understand the evolution of cattle, ruminants ...
Cached Biology News:UF receives $12.2 million to establish national network of scientists 2UF receives $12.2 million to establish national network of scientists 3WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3MU research team establishes family tree for cattle, other ruminants 2
(Date:9/15/2014)... by Northeastern University has developed a novel method ... variety of nanocarbon structures in carbon nanotube arrays. ... will allow the researchers to tailor the physical ... ranging from electronic devices to CNT-reinforced composite materials ... , Their findings were published in the journal ...
(Date:9/15/2014)... The chemistry, taste, and health effects of tea ... published by the nonprofit American Botanical Council (ABC). Recent research ... its effects on the phytochemical compounds in tea ( Camellia ... Dr. Ahmed in the Yunnan province ... for the future of medicinal botanicals. Dr. Ahmed,s report ...
(Date:9/15/2014)... , Sept. 15, 2014  The second annual ... October 12-18. A joint initiative of the Plasma ... companies , IPAW is designed to: , ... Recognize the contributions of plasma donors in saving and ... protein therapies and rare diseases Member ...
(Date:9/13/2014)... September 13, 2014 Boehringer Laboratories Inc., ... is proud to announce the successful broadcast of a ... surgeons Leonardo Claros, MD, FACS, FAMBS, and Maher El ... Gastrectomy Calibration System. , This sleeve gastrectomy surgery ... of more than four hundred surgeons from around the ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Tea Taste and Quality Affected by Climate Change 2Tea Taste and Quality Affected by Climate Change 3Tea Taste and Quality Affected by Climate Change 4International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 2International Plasma Awareness Week To Celebrate Donors And Spotlight Rare Diseases 3Boehringer Laboratories, Inc. Announces Live Surgery Using Innovative System to Calibrate Sleeve Gastrectomy 2
... ... V™ series to its portfolio. , ... San Francisco, Calif. (PRWEB) October 2, 2009 -- Perceptum Group, ... for biotech and specialty pharma companies. The new series includes Situational Leadership V™, Situational ...
... , ... Venture Network (SCVN) announces the recipients of the 2009 Orange County Emerging Growth Awards, ... yearly revenues, have experienced significant growth over the last 12 months and that have ... ...
... the consequences can be fatal, not only for the creature ... fuselage, causing stresses in the material which can later turn ... detect such damage at an early stage and simplify maintenance ... need any cables or batteries. They draw their energy from ...
Cached Biology Technology:Perceptum Group Announces New Situational Leadership V Series 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 2Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 3Southern California Venture Network Announces Recipients of the 2009 Orange County Emerging Growth Awards 4Energy-autonomous sensors for aircraft 2
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
... Orbital Shakers combine high durability and ... power. The patented triple-counterbalanced heavy-duty ... to run with heavy out-of-balance loads. ... reduces contamination. The heavy stainless ...
... T4 Polynucleotide Kinase (PNK) catalyzes ... ATP to the 5'-hydroxyl of single- ... 3'-monophosphates. The enzyme also removes the ... and deoxyribonucleoside 3', 5'-diphosphates to form ...
The Cellject Elecroporator is suitable for all cell types including embryo, mammalian, plant, yeast and bacterial. Its has highly user-freindly programing and can be used remotely, for example in a l...
Biology Products: