Navigation Links
Insulin pulses keep the liver lean

Insulin, a hormone long recognized as a generator of fat, also keeps fat in the liver under control, according to a new study in the July issue of Cell Metabolism. The newly discovered role for insulin may explain how an organ frequently flooded with the fat-building hormone normally stays trim and also suggests new dietary strategies and treatments to avoid fatty liver, a growing healthcare epidemic, said the researchers.

Insulin produced by the pancreas allows cells to take up glucose from the bloodstream and burn it for energy. In the liver, insulin promotes the synthesis and storage of lipids and carbohydrates and blocks their breakdown and release into the bloodstream. A failure to make or respond to insulin in people with diabetes causes blood sugar levels to rise.

The current study uncovered a new mechanism whereby acute insulin pulses limit fat synthesis in the liver. This protective mechanism fails in obese mice and mice with persistently high levels of insulin, the researchers also found.

The findings suggest that periods of fasting between meals play a critical role in maintaining a lean and healthy liver by allowing insulin levels to rise and fall, said study lead author Sonia Najjar of the Medical University of Ohio.

Furthermore, she said, the results emphasize the central role of the liver in metabolic control. A liver overwhelmed with insulin--as can occur in those who overeat--may become resistant to the hormone, leading to greater fat production and visceral weight gain. Resulting hikes in blood sugar and fat can also spell diabetes and heart disease, Najjar added.

"When we eat, the pancreas produces insulin, which stimulates the absorption of sugar and fat by the liver," Najjar said. "But in today's Western society, large portions and frequent munching may lead insulin levels to remain high all the time. In that case, the liver no longer perceives pulses of the hormone and becomes resistant."

The resea
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells
2. Insulin receptor stops progression of Alzheimers disease
3. Field of beams - Novel system uses polarized light pulses to reveal crop health
4. Scientists ID molecular switch in liver that triggers harmful effects of saturated and trans fats
5. New methods of gene delivery using lasers
6. UNC launches study of liver injury caused by drugs
7. Gene therapy cures inherited liver disease in rats
8. Mouse with designer liver has enhanced glucose tolerance, insulin response
9. Excess liver gene protects against high-fat diet
10. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
11. Self-assembled DNA buckyballs for drug delivery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insulin pulses keep the liver lean

(Date:4/17/2014)... House honored Clemson professor Rajendra Singh Thursday as ... promote and expand solar deployment in the residential, ... Houser Banks Professor of Electrical and Computer Engineering ... is considered a local hero leading the charge ... opportunity in solar power and driving policy changes ...
(Date:4/17/2014)... of forests in the Amazon help create tinderbox ... rapid and widespread forest loss during drought years, ... show that forests in the Amazon could reach ... forest fires lead to large-scale loss of trees, ... professor of geography, Penn State. , "We documented ...
(Date:4/17/2014)... Yokahama IPCC meeting painted a stark warning on the ... has a greenhouse effect 32 times that of carbon ... that humic substances act as fully regenerable electron acceptors ... held in wetlands instead of being released to the ... is disrupted it may enter into a vicious cycle ...
Breaking Biology News(10 mins):White House honors Clemson professor as 'Champion of Change' for solar deployment 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3Methane climate change risk suggested by proof of redox cycling of humic substances 2
... This release is available in German . ... ), the European forest cockchafer ( Melolontha hippocastani ) is ... can damage huge areas of broadleaf trees and conifers in ... that help them to digest their woody food, such as ...
... Cholesterol plays a key role in regulating proteins involved in ... processes, an international team of researchers has found. The ... Nature Communications . Cholesterol,s role in heart disease has ... of a cell, the tight regulation of cholesterol at high ...
... institutions from 15 European countries, Brazil, Israel and the ... BON - "Building the European Biodiversity Observation Network". This ... knowledge by building a European gateway for biodiversity information, ... both from on ground observations to remote sensing ...
Cached Biology News:Not without my microbes 2Not without my microbes 3Cholesterol helps regulate key signaling proteins in the cell 2Bringing big data to biodiversity 2Bringing big data to biodiversity 3
(Date:1/15/2014)... 2014 AudioNotch is the internet's leading ... the treatment of tinnitus. Patients listen to sound therapy ... a period of weeks to months, their tinnitus volume decreases. ... forms: Notched Music and Notched White Noise. Now, AudioNotch is ...
(Date:1/14/2014)... 14, 2014  3D Communications, a leading provider of strategic communications services ... media events in the United States and ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as Associate ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 iLab Solutions, the ... as the new Director of Product Strategy. In this role, ... as iLab sub-teams to guide in the development of iLab ... provides the maximum possible benefit to the scientific community by ...
(Date:1/14/2014)... (PRWEB) January 13, 2014 Bob Hainsey, ... more than 20 years in the industry, has joined ... . Hainsey will serve as the society’s Science and ... Hainsey join SPIE as our Technology Strategist, further strengthening ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... Koronis Pharmaceuticals, Inc., a,biotechnology company focused on ... of Daniel H. Petree and George R. Painter,Ph.D. ... Petree is a founder and member of P2 ... science companies. Prior to forming P2,Partners, Mr. Petree ...
... Researchers in South Africa latest to report patient ... Instruments, a,leading surgical device company, today announced that ... welding technology.,Physicians in North America, Europe, the Middle ... effective and precise instruments for a wide variety,of ...
... AMT), a leader in the field of human ... of rotation to appoint independent,directors to its Supervisory ... Philippe van Holle, Head of Celgene Europe (NASDAQ: ... shareholders. Mr. Van Holle is expected to,replace non-independent ...
Cached Biology Technology:Koronis Pharmaceuticals Announces Appointment of Daniel H. Petree and George R. Painter, Ph.D. to Board of Directors 2Starion Achieves Worldwide Distribution of Proprietary Tissue Welding Technology 2Amsterdam Molecular Therapeutics to Appoint Philippe van Holle (Celgene) to Supervisory Board 2Amsterdam Molecular Therapeutics to Appoint Philippe van Holle (Celgene) to Supervisory Board 3
384 well block MBSr. Robot compatible block ejection mechanism. Stackable. (384 well block - holds 384 well plate)...
... a macromolecular structure has been determined, the ... a widely diverse audience of scientists, educators ... literature and dissemination over the Internet, either ... web pages. Printed literature has the advantage ...
... 45° Fixed Angle Rotor ... Centra CL2, Centra CL3CL3R, and ... concentration of sputum samples and ... samples. Provides individual aerosol containment. ...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
Biology Products: