Navigation Links
'Insulator' helps silence genes in dormant herpes virus

By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1. After the initial infection, the virus usually remains in the body, hiding out in nearby nerve cells where the victim's immune defenses cannot reach it, causing no symptoms at all.

In order to escape detection by the body's immune system, the latent virus works to silence genes that would cause it to replicate. In this dormant state, only a tiny fragment of the virus genome ?a single gene called the Latency-Associated Transcript gene (LAT) ?remains active. Scientists have long puzzled over the mechanism used to keep this small region of the genome going while nearby genes remain quiescent.

Now, scientists at The Wistar Institute have discovered a molecular mechanism that keeps HSV-1 activation restricted to a single gene for months or even years. The researchers have identified an "insulator" ?a stretch of DNA about 800 base pairs long ?that serves as a physical barrier between active and inactive regions of the virus genome. Base pairs are the nucleotides on each side of the rungs that connect the strands of the DNA ladder.

"By establishing an insulator in early latency, the Herpes virus can protect this one small region of the genome from silencing, allowing infected cells to survive," says study senior author Jumin Zhou, Ph.D., an associate professor at The Wistar Institute.

The findings, appearing in the May issue of the Journal of Virology, mark the first time an insulator has been identified in a virus and may lead to ways to develop strategies to manipulate the virus.

Insulators, also known as boundary elements, are DNA segments that work to prevent a gene from being influenced by the activation or repression of its neighbors. About a dozen different insulator elements have been identified in organisms as varied as yeast, fruit flies, and humans.

Not simply pass
'"/>

Source:The Wistar Institute


Page: 1 2 3

Related biology news :

1. Jumping gene helps explain immune systems abilities
2. Protein helps regulate the genes of embryonic stem cells
3. Scientists reveal the shape of a protein that helps retroviruses break into cells
4. Thai spice helps cut blood sugar swings
5. Chemists synthesize molecule that helps body battle cancers, malaria
6. Ancient DNA helps clarify the origins of two extinct New World horse species
7. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
8. Study: Well-known protein helps stem cells become secretory cells
9. Beyond genes: Lipid helps cell wall protein fold into proper shape
10. Simple sea sponge helps scientists understand tissue rejection
11. New technique helps identify multiple DNA regulatory sites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insulator helps silence genes dormant herpes virus

(Date:3/30/2015)... DUBLIN , Mar. 26, 2015 Research and ... addition of the "Global Gesture Recognition Market in ... The analysts forecast the Global Gesture Recognition market ... 12.8% over the period 2013-2018. Gesture recognition ... respond to different gestures of an individual. Gesture recognition ...
(Date:3/24/2015)... and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has announced the addition ... Report" report to their offering. This report analyzes ... by the following Segments: Face Biometrics, and Voice Biometrics. The report ... , Japan , Europe , ... & Africa , and Latin America ...
(Date:3/23/2015)... -- SoundView Technology Group issues a new research update following ... smart wallet. SoundView was one of the selected user groups to ... Wocket in multiple scenarios and outlets. Soundview ... making both debit and credit card payments.  ... company meets their plans in 2015, it would push our ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... ?one from Louisiana, one from Japan and one ... to involvement of endocannabinoids as a novel neural ... in eating, disease treatment and social behavior. , ... team from Tulane and Louisiana State Universities, led ...
... as fertility drugs may be ineffective for women who ... study showed that fertility drugs did not improve ovulation ... estrogen receptor beta. The estrogen receptor beta is one ... of estrogen hormones and are present throughout the female ...
... extension in yeast have been identified by researchers from UC ... or caloric restriction, is known to extend the lifespan of ... gene called Sir2 with lifespan extension due to caloric restriction, ... when put on a tough diet, showing that some other ...
Cached Biology News:Endocannabinoids ?the brain's cannabis ?demonstrate novel modes of action to stress 2New Discovery May Help Doctors Treat Infertility 2New Discovery May Help Doctors Treat Infertility 3
(Date:5/5/2015)... VetStem Biopharma, proudly announces former ... Schaffer, DVM, as Director of Veterinary Professional Services. ... experience in the veterinary regenerative medicine field Dr ... veterinarian lead organization”. Dr. Alexis Nahama, President ... be responsible for all technical activities in relationship ...
(Date:5/5/2015)... Psyche Systems Corporation and Luminate Health have ... platform that helps labs comply with new federal HHS ... way patients engage with these results, and improves provider ... a HIPAA-compliant digital platform that gives labs an easy ... lab results, and uniquely connects labs, physicians, and patients ...
(Date:5/5/2015)... , May 5, 2015  Renova™ Therapeutics, a ... heart failure and other chronic diseases, has engaged ... analysis designed to reflect the healthcare patterns of ... model will be used to characterize the impact ... have on those groups of patients and the ...
(Date:5/5/2015)... 5, 2015  A group of biotechnology executives and ... Research Institute, a non-profit organization dedicated to providing education, ... from disorders of consciousness.  ... ... which no voluntary actions can be initiated by the ...
Breaking Biology Technology:Leading Regenerative Veterinary Medicine Company, VetStem Biopharma announces the addition of Dr Jeffrey Schaffer as the Director of Veterinary Professional Services. 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 2Psyche Systems Corporation Forms Strategic Alliance with Luminate Health to Provide First-of-its-kind Patient Access Solution 3RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 2RAND Health Advisory Services modeling heart failure patient outcomes to inform potential impact of Renova Therapeutics lead product candidate 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 2Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 3Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 4Biotechnology Executives and Medical Doctors Team Up to Tackle Coma and Disorders of Consciousness 5
... 15 /PRNewswire-Asia-FirstCall/ -- China Integrated,Energy, Inc. (Nasdaq: CBEH ; ... announced its selected unaudited,preliminary financial results for the third quarter ... sales to be at least $71 million and net income ... 4.4%,respectively, compared to the third quarter of 2008. , ...
... , BRIARCLIFF MANOR, N.Y., Oct. 15 The mission ... is to advance the medical publication profession through education ... growing misperceptions in the medical literature and lay press ... such as the perception that all medical writing is ...
... Cytochroma today announced that it has appointed John Cunningham, ... Advisory Board. , Dr. Cunningham is Professor of Nephrology ... at the Royal Free Hospital, London. His early training ... in The University of London and Washington University ...
Cached Biology Technology:China Integrated Energy, Inc. Announces Preliminary Third Quarter Financial Results and Increases Full Year Guidance 2ISMPP Supports Best Practices and Transparency in Medical Publications: Better Understanding of Terms Such as 'Ghostwriting' Needed 2ISMPP Supports Best Practices and Transparency in Medical Publications: Better Understanding of Terms Such as 'Ghostwriting' Needed 3Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board 2Cytochroma Appoints Dr. John Cunningham to its Scientific Advisory Board 3
Human/Mouse/Rat LAR Affinity Purified PAb...
X-Gal, 100 mg. 5-Bromo-4-chloro-3-indolyl-b-d-galactoside.Histochemical substrate for b-galactosidase, used in blue/white screening.Store at -20 C. Protect from moisture. Category: Nucleotides & Enzy...
Human Jagged 2 Biotinylated Affinity Purified PAb...
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)...
Biology Products: