Navigation Links
'Insulator' helps silence genes in dormant herpes virus

By adulthood, most people have suffered at least one bout of painful cold sores brought on by the Herpes simplex virus 1, also known as HSV-1. After the initial infection, the virus usually remains in the body, hiding out in nearby nerve cells where the victim's immune defenses cannot reach it, causing no symptoms at all.

In order to escape detection by the body's immune system, the latent virus works to silence genes that would cause it to replicate. In this dormant state, only a tiny fragment of the virus genome ?a single gene called the Latency-Associated Transcript gene (LAT) ?remains active. Scientists have long puzzled over the mechanism used to keep this small region of the genome going while nearby genes remain quiescent.

Now, scientists at The Wistar Institute have discovered a molecular mechanism that keeps HSV-1 activation restricted to a single gene for months or even years. The researchers have identified an "insulator" ?a stretch of DNA about 800 base pairs long ?that serves as a physical barrier between active and inactive regions of the virus genome. Base pairs are the nucleotides on each side of the rungs that connect the strands of the DNA ladder.

"By establishing an insulator in early latency, the Herpes virus can protect this one small region of the genome from silencing, allowing infected cells to survive," says study senior author Jumin Zhou, Ph.D., an associate professor at The Wistar Institute.

The findings, appearing in the May issue of the Journal of Virology, mark the first time an insulator has been identified in a virus and may lead to ways to develop strategies to manipulate the virus.

Insulators, also known as boundary elements, are DNA segments that work to prevent a gene from being influenced by the activation or repression of its neighbors. About a dozen different insulator elements have been identified in organisms as varied as yeast, fruit flies, and humans.

Not simply pass
'"/>

Source:The Wistar Institute


Page: 1 2 3

Related biology news :

1. Jumping gene helps explain immune systems abilities
2. Protein helps regulate the genes of embryonic stem cells
3. Scientists reveal the shape of a protein that helps retroviruses break into cells
4. Thai spice helps cut blood sugar swings
5. Chemists synthesize molecule that helps body battle cancers, malaria
6. Ancient DNA helps clarify the origins of two extinct New World horse species
7. Massey Cancer Center researcher helps to identify a piece of the cancer puzzle
8. Study: Well-known protein helps stem cells become secretory cells
9. Beyond genes: Lipid helps cell wall protein fold into proper shape
10. Simple sea sponge helps scientists understand tissue rejection
11. New technique helps identify multiple DNA regulatory sites
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insulator helps silence genes dormant herpes virus

(Date:2/11/2015)... 2015 According to ... Market by Product (Cards and Readers, Biometrics, Controllers, Management ... Industrial, Healthcare, Education) and By Geography - Global Forecast and Analysis ... Access Control Market is expected to reach ... CAGR of 10.6% between 2014 and 2020. ...
(Date:2/5/2015)... North Carolina , 5. Februar 2015 ... Jahr als spezialisiertes Logistikunternehmen und hat eine ... einzige klinische Logistikfirma (Clinical Logistics Organization – ... der neuen Kampagne lautet First , ... Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... Conn. , Jan. 26, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... new corporate website ( http://www.nxt-id.com/ ) as part of ... smart wallet. The Company launched its new consumer website ... Gino Pereira , CEO of NXT-ID said, "Our new ...
Breaking Biology News(10 mins):Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3
... A University of Granada researcher has been awarded the ... Meeting, an international conference of computed microtomography recently celebrated in ... Zoology has been awarded for his biofilm titled Micro-CT anatomical ... the genus Dryops . This film shows from the ...
... of California, Riverside have a "proof of concept" that ... behavior and survival of honey bees. Selenium ... normal development of insects and humans but ... replaces sulfur in amino acids. In soils, particularly ...
... named as the lead university in the United Kingdom ... and engineering., It is the only UK University to ... SWAN Charter awards, which recognise the commitment of institutions, ... gender inequalities and improving career progression for female academics., ...
Cached Biology News:Spanish researcher releases a video showing a beetle from the inside 2Selenium impacts honey bee behavior and survival 2Selenium impacts honey bee behavior and survival 3Queen's is UK leader for female scientists and engineers 2
(Date:2/26/2015)... , Feb. 26, 2015   Regulus Therapeutics ... company leading the discovery and development of innovative medicines ... , Ph.D., President and Chief Executive Officer of Regulus, ... Company 35 th Annual Healthcare Conference on Wednesday, ... is being held at the Boston Marriott Copley Place.  ...
(Date:2/26/2015)... 26, 2015  NuGene International, Inc. ("NuGene") (OTCQB: ... skin and hair rejuvenation, has announced that it ... record for investor relations and strategic communications. ... sales and diversification strategies – and we need ... shareholders," stated Ali Kharazmi CEO of NuGene when ...
(Date:2/26/2015)... 2015 Innovation is more urgent ... unexpected parts of the world and transforming global ... to manufacturing to health care, disruption is constantly ... and socio-political trends shake the foundations of established ... for CEOs to survive the next wave of ...
(Date:2/26/2015)... 2015 Ceres, Inc . today announced ... PartnerNetwork. In attaining Gold Level membership, Ceres has been ... knowledge in delivering Ceres, Persephone genome visualization software and ... Originally developed for in-house use by Ceres, the ... out of massive amounts of genetic data, from a ...
Breaking Biology Technology:Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 2NuGene International, Inc. Selects Capital Market Relations for Strategic Investor Relations 3One Million Acts of Innovation Canada Creates Partnership with The Economist Events’ Innovation Forum 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 2Ceres Becomes Oracle PartnerNetwork Gold Level Partner 3Ceres Becomes Oracle PartnerNetwork Gold Level Partner 4
... Generation Pro-Healing Technology Developments UnveiledSEOUL, South Korea, April ... at a symposium during Angioplasty Summit TCT Asia ... Grande Walkerhill Hotel in Seoul, South Korea. ... Medical Center (AMC), Amsterdam, The Netherlands, final adjudicated ...
... Microtest Laboratories ( www.microtestlabs.com ) ... its position as a proven, one-stop provider of contamination ... for manufacturers of medical devices or pharmaceuticals.Microtest helps manufacturers ... compliance as well as to achieve greater productivity. ...
... Young Companies will Present at the Largest Marketplace for ... NSTI and CTSI today announced that more than 100 ... commercialization partners will be showcased in the 4th Annual ... George R. Brown Convention Center in Houston, Texas. ...
Cached Biology Technology:OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Demonstrates Impressive Results in Higher Risk Patients 2OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Demonstrates Impressive Results in Higher Risk Patients 3Microtest Labs Expands Clean Room, Contamination Testing Services 2Microtest Labs Expands Clean Room, Contamination Testing Services 3Microtest Labs Expands Clean Room, Contamination Testing Services 4TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 2TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 3TechConnect Summit Brings the Global Technology Community to Houston, May 4-6, 2009 4
... is a direct antibiotic-based ... identification. Recombinant selection depends ... eliminating the need for ... quick and inexpensive process ...
... has been designed and created in order ... friendly genotyping analysis tool. We incorporated the ... into the software. Their main requirements were ... low acquisition cost. GeneMarker can perform ...
... phase extraction through columns is a well-known ... applications. Typical applications are in DNA/RNA extraction ... or compound purification in chemical or analytical ... on the Genesis series instruments for smaller ...
... 3D structure visualization, phylogenetic tree building, sequence ... single application. Retrieve ... and filter them in real-time Organize ... searching, filtering and sorting Provides up-to-date ...
Biology Products: