Navigation Links
Institute for Systems Biology Symposium Addresses Need for Better Computational Tools

The Institute for Systems Biology announced today at its 2005 international symposium on Computational Challenges in Systems Biology that ISB's Human Proteome Folding Project launched on IBM's World Community Grid in November 2004 has already predicted 50,000 protein structures.

"This project showcases the enormous power of collaborations," stated Dr. Richard Bonneau, senior scientist at the Institute for Systems Biology. "Through a partnership with IBM we are utilizing World Community Grid which is enabling us to complete a project in less than a year that would have taken us approximately 100,000 years to complete with the current computational power at ISB. We have already predicted 50,000 protein structures and are well on our way to reaching the goal of between 100,000 - 150,000 structures."

The project, funded by IBM and tapping into the unused computational power of idle computers is helping predict the shape of human proteins and helping make new scientific and medical breakthroughs come at an ever faster pace-certainly more rapidly than in any new field of biology in the 20th Century. Annotating these proteins of unknown function remains a critical bottleneck for systems biology and is crucial to understanding the biological relevance of genome-wide changes in mRNA and protein expression, protein-protein and protein-DNA interactions.

World Community Grid is enabling ISB researchers to predict three dimensional structures, which are more highly conserved than one dimensional structures. Understanding three dimensional structures allow researchers to identify the presumptive function of proteins. These functions can then be assigned to appropriate networks. Researchers expect that approximately 2/3 of the folded proteins will result in correct topologies and that approximately 1/3 of the predicted structures will match previous folds now stored in the protein data bank/PDB.

Folded proteins explain many biological functions -- ju
'"/>

Source:Institute for Systems Biology


Page: 1 2

Related biology news :

1. Weizmann Institute scientists develop a new approach for directing treatment to metastasized prostate cancer in the bones.
2. Affymetrix and the Karolinska Institutet Announce Translational Medicine Strategic Alliance
3. BioMed Central welcomes the new National Institutes of Health public access policy
4. Virginia Tech, Nanjing Institute researchers discover half-billion year-old fossils
5. UC San Diego partners with Venter Institute to build marine microbial genomics cyberinfrastructure
6. Weizmann Institute suggests that immune cells help to maintain cognition and brain cell renewal
7. Virginia Bioinformatics Institutes launches microbial database
8. Weizmann Institute scientists discover a molecular security mechanism for keeping mutations in check
9. Latest advances in DNA sequencing highlighted at DOE Joint Genome Institute User Meeting
10. UCLA AIDS Institute researchers find a peptide that encourages HIV infection
11. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
Post Your Comments:
(Date:7/11/2014)... the normal circumstances, astrocytes participate in normal ... and exhibit therapeutic and repairing effects on ... have found that nerve cells differentiated from ... reduced viability, which produces influences on subsequent ... General Hospital, Hebei United University, China demonstrated ...
(Date:7/11/2014)... Rio de Janeiro, Brazil- In the brains of ... mechanism that allows an electric or chemical signal ... another. Chemical synapses, which are the most abundant ... inhibitory. Synapse formation is crucial for learning, memory, ... and inhibitory synapses critical for brain function. ...
(Date:7/10/2014)... , June 30, 2014  Aware, Inc. (NASDAQ: ... software and services, previously announced on June 26, 2014 ... cash dividend of $1.75 per share, or approximately $40 ... of July 10, 2014 and a payment date of ... NASDAQ that it had set an ex-dividend date for ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2
... a fetus to get nutrition and oxygen from its mother,s ... That crosstalk allows the mother,s blood to flow out of ... away from the fetus, blood, says Dr. Puttur D. Prasad, ... That controlled exchange between the blood of mother and ...
... Think researchers know all there is to know about ... "E. coli has more than four thousand genes, and ... Dr. Deborah Siegele, a biology professor at Texas A&M ... the bacterium. , Harmless E. coli strains are normally ...
... The Iowa Corn Promotion Board (ICPB), NJIT and University ... licensing four pending patents on a safe, building block ... The agreement marks a step forward in developing ... "This agreement gives us the exclusive right to work ...
Cached Biology News:Likely cause of postpartum blues and depression identified 2Likely cause of postpartum blues and depression identified 3GIANT-Coli: A novel method to quicken discovery of gene function 2Iowa Corn Promotion Board, NJIT to license breakthrough, safe bio-plastic alternative 2
(Date:7/10/2014)... , July 10, 2014  Franciscan ... use of capnography for respiratory monitoring outside ... of healthcare leaders in embracing state-of-the-art patient ... effectively patients are breathing and can alert ... By measuring the amount of carbon dioxide ...
(Date:7/10/2014)... 2014   Ceres, Inc . (Nasdaq: ... today financial results for the three months ended May ... Ceres reported that the company and its ... growing season in Brazil, which concluded in June, despite ... evaluation areas for part of the growing season. Yields ...
(Date:7/10/2014)... Understanding the basis of psychiatric disorders has been extremely ... increase risk but are insufficient to cause disease. Now ... Cell Press journal Cell Stem Cell describe ... genetic risks interact with other risk factors or environmental ... Their research pinpoints a genetic variant that may predispose ...
(Date:7/10/2014)... the University of Illinois at Urbana-Champaign provides new ... of spin and heat at the nanoscale, and ... for data storage and information processing. , ... momentum. In a typical charge current, electrons, spin-angular-momentum ... explained David Cahill, a professor of materials science ...
Breaking Biology Technology:Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2University of Illinois study advances limits for ultrafast nano-devices 2
... Issues Have Been Resolved; Remaining Issues Pertain to ... of Third-party Manufacturing Facility Company Expects to ... LEXINGTON, Mass., Dec. 19 Indevus,Pharmaceuticals, Inc. (Nasdaq: ... letter from the U.S. Food and Drug Administration (FDA) ...
... Allows Accurate Marketing Claims Designed with Input from,Entire ... nation,s leading livestock,cloning companies announced today a tracking ... allow food companies to identify cloned animals,when they ... program was developed through extensive cooperative discussions,over the ...
... Announcement of a Tracking Program for,Cloned Livestock, ... by International Dairy Foods Association President and CEO ... new national registry to track cloned,livestock as a ... food,products from cloned animals. However, we strongly urge ...
Cached Biology Technology:Indevus Receives Non-Approvable Letter From FDA for VALSTAR(TM) 2Indevus Receives Non-Approvable Letter From FDA for VALSTAR(TM) 3Indevus Receives Non-Approvable Letter From FDA for VALSTAR(TM) 4Top U.S. Cloning Companies Announce New System to Track Cloned Livestock 2Statement of International Dairy Foods Association President and CEO Connie Tipton 2