Navigation Links
Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

New work reported in the March issue of Cell Metabolism has provided insight into a key mechanism by which cells limit cholesterol synthesis. The finding suggests a novel approach to the development of cholesterol-lowering drugs that may boost the effect of statins, one of the most prescribed cholesterol inhibitors, according to researchers at the University of Texas Southwestern Medical Center.

Cells obtain cholesterol, an important component of cell membranes, by building it internally or by taking it up from the bloodstream. The cholesterol-building process involves more than 25 enzymes, including one called HMG CoA reductase, and many layers of regulatory control, said Russell DeBose-Boyd, senior author of the study.

Scientists have long known that cells respond to a high cholesterol diet by shutting down its internal synthesis, he explained. However, the molecular mechanisms by which cholesterol and other related compounds exert that self-control have only more recently begun to emerge.

The researchers now demonstrate that lanosterol--an intermediate compound in the synthetic pathway--mediates feedback control over the rate of cholesterol production by stimulating the degradation of cholesterol-building reductase. The availability of reductase, which functions early in the synthetic process, largely determines the rate of cellular cholesterol production, Debose-Boyd said.

When added to intact cells and cellular components in test tubes, lanosterol led other proteins to mark reductase for destruction by attaching a protein called ubiquitin in a process called ubiquitination. Ubiquitination is a common mechanism for stimulating protein degradation. Cholesterol itself had no such effect on reductase, even at much greater concentrations, they found.

"The current results demonstrate a direct role for lanosterol as a selective, physiologic regulator of reductase ubiquitination and degradation," said DeBose-Boyd. That effect woul
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
3. Insight into DNAs weakest links may yield clues to cancer biology
4. Insight into our sight: A new view on the evolution of the eye lens
5. Insight into the processes of positive and negative learners
6. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
7. What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brains Internal Clock
8. Genetically modified natural killer immune cells attack, kill leukemia cells
9. UCSD discovery may help extend life of natural pesticide
10. UCLA scientists store materials in cells natural vaults
11. Man-made wetlands effectiveness similar to natural marsh
Post Your Comments:
(Date:7/24/2014)... multi-institutional team of researchers has developed a new nanoscale ... noninvasive method for assessing the function and properties of ... better diagnosis and treatment of gut diseases. ... bowel syndrome and inflammatory bowel disease all occur in ... in patients with diseases such as diabetes and Parkinson,s. ...
(Date:7/24/2014)... at The University of Texas Health Science Center at ... to help Harris County residents whose vision problems cannot ... with corrective lenses, many people with low vision can ... of low vision devices, such as telescopes, magnifiers and ... Iyer is using the three-year, $164,645 SightFirst grant from ...
(Date:7/24/2014)... cleanup experts gathered at NJIT this week for an ... the U.S. Environmental Protection Agency (EPA) to dredge toxic ... River. , The EPA has called the plan, which ... and capping sections of the riverbed, one of the ... would be dredged and disposed off-site. , "We need ...
Breaking Biology News(10 mins):New imaging agent provides better picture of the gut 2UTHealth Dr. Bhavani Iyer awarded low vision grant 2Experts Weigh the Pros and Cons of a $1.7 Billion EPA Cleanup Plan for the Passaic River at an NJIT 2
... Boston University School of Medicine (BUSM) demonstrates a new mechanism ... the formation of new blood vessels and cancer growth. The ... Signaling . Angiogenesis creates new blood vessels in a ... several diseases such as cancer and age-related macular degeneration. ...
... A new study published in the December issue of ... only in terms of its impact on current coastal conditions ... past. Hurricane Irene made landfall in Onslow Bay, North Carolina, ... been downgraded to a Category 1 hurricane after hitting the ...
... Do fruit flies hold the key to treating dementia? ... a significant step forward in unraveling the mechanisms of ... memories form and, ultimately, provide better treatments to improve ... associate professor of biology and biochemistry at UH, and ...
Cached Biology News:New clues to memory formation may help better treat dementia 2New clues to memory formation may help better treat dementia 3
(Date:7/24/2014)... Draper University, a top program ... announce that for 6 weeks this summer, 39 ... on the Draper University campus in the heart ... focused on entrepreneurship, building real-world skills, and “learning ... its sixth cohort, continues to refresh its curriculum ...
(Date:7/24/2014)... 24, 2014   Cypher Genomics, Inc., ... of Adam Simpson as president and ... and comprehensive annotation and interpretation of individual human ... "Cypher,s technology has the potential to play ... diagnostic accuracy, optimizing therapeutic approaches and reducing adverse ...
(Date:7/24/2014)... San Diego, CA (PRWEB) July 24, 2014 ... in the reporting of molecular diagnostic test results. ... tracking capabilities necessary for the validation and reporting ... in oncology. Molecular diagnostics is a rapidly growing ... for infectious disease, genetic predisposition, cancer, and companion ...
(Date:7/23/2014)... United Arab Emirates (UAE) (PRWEB) July 23, 2014 ... Grace Century recently announced that its biobanking project, ... Vaught , Ph.D. to its growing Advisory Board. ... are very pleased to have Dr. Vaught onboard with ... scientific depth and expertise that Provia’s management team brings ...
Breaking Biology Technology:Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 2Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 3Provia Laboratories Adds Dr. Jim Vaught, Ph.D., Former Chief of BBRB, to Advisory Board 4
... 22, 2011 Qteros, Inc., the developer of a ... platform for the lowest-cost production of cellulosic ethanol, today ... in June. Susan Hager, Qteros, Vice President ... the 2011 BIO International Convention at the Walter E. ...
... 21, 2011 ,   ... of Matthew Roe as Chief Business Officer. Matthew ... Director,Business Development & Licensing. During a ... alliance management, acquisition, divestment, and sales,and marketing, and ...
... physics there are two classes of fundamental particles. Photons, ... and neutrons that make up atomic nuclei belong to ... at a very basic level. This difference is expressed ... species of fundamental particle was postulated, which was dubbed ...
Cached Biology Technology:Qteros Management to Speak at June Conferences 2Crescendo Biologics Appoints Matthew Roe as Chief Business Officer 2Acrobatics for anyons: New test for elusive fundamental particle proposed 2
Red Standard is sodium salt of resorufin....
APG5 autophagy 5-like (S. cerevisiae)...
...
Griess Reagent component for determination of nitrite in aqueous solutions....
Biology Products: