Navigation Links
Insight into DNA's 'weakest links' may yield clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

The findings, published in the March 11, 2005, issue of Cell, suggest that yeast may offer a useful model system for studying the fundamental properties of so-called DNA fragile sites, providing new insight into the chromosomal instability found in cancer cells, said the researchers.

"If you look at solid tumors in humans, you see that the chromosomes of cancer cells exhibit incredible instability," said Thomas Petes, Ph.D., chair of genetics and microbiology at Duke. "Now, we have been able to mimic some of that instability in yeast cells and can begin to ask whether there is anything special that defines those places where chromosomes tend to break."

Organisms normally exhibit extremely low rates of mutation and chromosomal rearrangements. Conditions that elevate genomic instability lead to an increase in cell death and, in some cases, an increased incidence of cancer, Petes said.

Earlier work by other researchers had shown that mammalian chromosomes break at particular sites under certain types of stress or upon exposure to particular drugs, he said. Evidence has suggested that chromosomes break when DNA replication ?the process by which DNA copies itself before cell division ?slows or stalls. However, the DNA characteristics that make particular sites vulnerable to breakage had remained unclear, he said.

The researchers slowed DNA replication in yeast cells by reducing the availability of one form of DNA polymerase, which are enzymes critical in DNA duplication. Yeast with abnormally low levels of DNA polymerase exhibited higher frequencies of chromosomal loss a
'"/>

Source:Duke University Medical Center


Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Insight into our sight: A new view on the evolution of the eye lens
5. Insight into the processes of positive and negative learners
6. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
7. What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brains Internal Clock
8. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
9. Uncovering DNAs sweet secret
10. Genome-wide mouse study yields link to human leukemia
11. Microbial fuel cell: High yield hydrogen source and wastewater cleaner
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insight into DNA weakest links may yield clues cancer biology

(Date:2/12/2015)... 12, 2015   MedNet Solutions , a ... study management systems, has recently bolstered its ... iMedNet as the eClinical ... and healthcare consultants.  Building on the Program,s existing ... and numerous co-marketing opportunities), MedNet,s new and improved ...
(Date:2/9/2015)... Texas , Feb. 9, 2015  Lintec of ... fabrication methods for carbon nanotube (CNT) macrostructures, including sheets, ... at Dallas (UTD). Leveraging the vast industrial ... Tokyo, Japan , Lintec of America is ... Richardson, TX , focusing on scaling up ...
(Date:2/5/2015)... NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market, announces the ... as part of its 2015 marketing and branding initiatives ... new consumer website for Wocketwallet.com earlier this month. ... said, "Our new corporate website naturally showcases our premiere ...
Breaking Biology News(10 mins):MedNet Solutions Announces Key Enhancements To Its iMedNet Partner Program 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 2Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 3Lintec announces exclusive license to commercialize innovative carbon nanotube technology from the University of Texas at Dallas 4NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3
... tomography (CT) scans can be used with three-dimensional (3-D) printers ... research published online in the journal Radiology . ... protect them from damage. Getting information about a fossil typically ... surrounding it, which can lead to loss of material or ...
... Dynasil Corporation of America (NASDAQ: DYSL ) ... received four grants totaling $4.0 million under the U.S. Department ... Technology Transfer (STTR) Programs. "RMD,s world-class research ... of new technologies," said Peter Sulick , Dynasil,s Chairman ...
... foods are more fattening than others? What about the ... Society for Nutrition (ASN) on December 5-7 for answers ... Controversies in Clinical Nutrition Conference. The 3-day ... areas, several different satellite sessions, and networking opportunities. Credentialed ...
Cached Biology News:Researchers use CT and 3-D printers to recreate dinosaur fossils 2Dynasil's RMD Subsidiary Awarded $4 Million in Technology Development Grants by U.S. Department of Energy 2Dynasil's RMD Subsidiary Awarded $4 Million in Technology Development Grants by U.S. Department of Energy 3Advances and Controversies in Clinical Nutrition: Diet, Technology and Practice 2
(Date:3/3/2015)... /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), a life sciences company ... for advanced microarray diagnostics, today announced it has ... Management team. In his capacity as CFO he ... a development stage to a commercially successful company ... capital market strategy and to secure funding to ...
(Date:3/3/2015)... FAYETTEVILLE, Ark. (PRWEB) March 03, 2015 ... Resource Systems Inc. to their international sales network. ... efficient gas dissolution technology to Canada’s Atlantic Provinces, ... Systems has served as one of Canada’s premiere ... clients in both the municipal water and wastewater ...
(Date:3/3/2015)... LITTLE FALLS, N.J. , March 3, 2015 /PRNewswire/ ... a biotechnology company specializing in the development of and ... of damaged tissues and organs, announced today that it ... Purchase Agreement with Amarantus Bioscience Holdings, Inc. (OTC Bulletin ... required under the Agreement, Amarantus made the final payments ...
(Date:3/3/2015)... The winners of awards for supply chain resilience ... Global Supply Chain Resiliency Council (GSCRC) at the ... 25th, 2015, at the Hyatt Regency in Santa Clara, ... supply chain risk management and resiliency practitioners with luminaries ... opportunities to collaborate, develop and share best practices, and ...
Breaking Biology Technology:SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3BlueInGreen® Continues Canadian Expansion, Partners with Resource Systems Inc. 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 3Global Supply Chain Resiliency Council Names Award Winners 2Global Supply Chain Resiliency Council Names Award Winners 3Global Supply Chain Resiliency Council Names Award Winners 4
... Plymouth, Wis. - Orion Energy Systems , a ... portion of new venture funding to develop and deploy new ... energy efficiency improvements. , ,The Technology Transformation Venture Fund, a ... Capital , and the Capvest Venture Fund of ...
... robust information technology industry, Wisconsin may have to undergo ... E-Business Best Practices and Emerging Technologies Conference. , ,In ... John Jazwiec, have not been shy about the ... E-Business conference did not cite Jazwiec's menu of steep ...
... Wis. - An impending acquisition would enable ... of more than 110 million automotive batteries annually, ... Eastern European countries, the company said. , ,In ... understanding," Johnson Controls, which is developing a next-generation ...
Cached Biology Technology:Orion Energy completes $5M capital round 2To drive IT, Wisconsin may need entrepreneurial makeover 2To drive IT, Wisconsin may need entrepreneurial makeover 3
... The Rapid-Screen cDNA Library Panels were designed ... three sets of PCRs to identify the ... is performed in a 96-well "Master Plate," ... 5,000 clones. Having identified the positive well(s) ...
... The ES Cell Characterization Kit consists of ... determination as well as four ES cell-specific ... controls). • Stem cells have become the ... to their therapeutic potential and because they ...
... Preparation Note: Prepared by a modification ... et al., Biotechnol. Bioeng., ... One unit will yield an A ... ml of water (1 cm light ...
... 1,4-Dithiothreitol DTT White crystalline solid. ... by titration. Contaminants: DNases, proteases, ... cm, 260 nm): ≤0.500; (100 mM, 1 ... metals: ≤0.001%. Soluble in H 2 ...
Biology Products: