Navigation Links
Insight into DNA's 'weakest links' may yield clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

The findings, published in the March 11, 2005, issue of Cell, suggest that yeast may offer a useful model system for studying the fundamental properties of so-called DNA fragile sites, providing new insight into the chromosomal instability found in cancer cells, said the researchers.

"If you look at solid tumors in humans, you see that the chromosomes of cancer cells exhibit incredible instability," said Thomas Petes, Ph.D., chair of genetics and microbiology at Duke. "Now, we have been able to mimic some of that instability in yeast cells and can begin to ask whether there is anything special that defines those places where chromosomes tend to break."

Organisms normally exhibit extremely low rates of mutation and chromosomal rearrangements. Conditions that elevate genomic instability lead to an increase in cell death and, in some cases, an increased incidence of cancer, Petes said.

Earlier work by other researchers had shown that mammalian chromosomes break at particular sites under certain types of stress or upon exposure to particular drugs, he said. Evidence has suggested that chromosomes break when DNA replication ?the process by which DNA copies itself before cell division ?slows or stalls. However, the DNA characteristics that make particular sites vulnerable to breakage had remained unclear, he said.

The researchers slowed DNA replication in yeast cells by reducing the availability of one form of DNA polymerase, which are enzymes critical in DNA duplication. Yeast with abnormally low levels of DNA polymerase exhibited higher frequencies of chromosomal loss a
'"/>

Source:Duke University Medical Center


Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Insight into our sight: A new view on the evolution of the eye lens
5. Insight into the processes of positive and negative learners
6. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
7. What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brains Internal Clock
8. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
9. Uncovering DNAs sweet secret
10. Genome-wide mouse study yields link to human leukemia
11. Microbial fuel cell: High yield hydrogen source and wastewater cleaner
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insight into DNA weakest links may yield clues cancer biology

(Date:8/28/2014)... available in German . ... built with the help of sophisticated assembly lines. Mobile assembly ... important part of these assembly lines. In the case of ... work stages arranged in a precise spatial and chronological sequence, ... line. , The creation of such an assembly line at ...
(Date:8/28/2014)... the first person to alert the world to Global ... be captured and stored underground. He says that Carbon ... the best way to avoid global warming getting out ... (Columbia University, New York) made the call during his ... where 150 scientists are meeting to discuss Carbon Capture ...
(Date:8/28/2014)... action is needed to ensure safeguards are in place ... PLOS ONE , researchers from Monash University, Stellenbosch ... combining results from different studies - to look at ... to determine whether they actually protect biodiversity. , ... an area from human exploitation made common sense, however, ...
Breaking Biology News(10 mins):Nanoscale assembly line 2Nanoscale assembly line 3Global warming pioneer calls for CO2 to be taken from atmosphere and stored underground 2Protected areas proven to protect biodiversity 2
... Expeditions in Computing program has awarded $10 million to ... at the California Institute of Technology and the University ... design of complex molecular and chemical systems based on ... of their study, molecular programs, are collections of molecules ...
... understand the decline and slow recovery of Atlantic salmon, ... fish native to New England rivers. Biologists agree that ... and Canada, but specific causes are difficult to determine ... may provide some answers. Thirty of 150 ...
... cause blood to clot and scabs to form when you ... cerebral malaria, an often lethal complication that occurs mostly in ... tropical and subtropical regions, malaria is one of the oldest ... the most studied pathogens of all time. Still, cerebral malaria, ...
Cached Biology News:Caltech researchers awarded $10M for molecular programming project 2Signals from the Atlantic salmon highway 2Signals from the Atlantic salmon highway 3Signals from the Atlantic salmon highway 4Johns Hopkins scientists discover what drives the development of a fatal form of malaria 2
(Date:8/28/2014)... 2014 Best Sanitizers, Inc., a leader ... processing industry, is asking industry professionals to prepare for ... the E2 soap they’re currently using to the Best ... Hand hygiene is critical to fighting cross-contamination and ... Six key criteria are identified to evaluate the effectiveness ...
(Date:8/28/2014)... Ind. A new research platform uses ... of tiny structures undergoing stress and heating, ... improve designs for microelectronics and batteries., This ... information about how heating and the surface ... properties. Researchers have discussed the merits of ...
(Date:8/28/2014)... The ability for organizations to attract ... allow individuals to perform at the highest of levels, ... looking to compete in this post–recession era. The ... as the sector increasingly focuses on the importance of ... have real results on the organization's development and the ...
(Date:8/28/2014)... August 28, 2014 Sterlitech is proud ... membranes to its stable of products . ... weight cut-offs and include membrane filters with surface charges. ... in customer demand for our membrane process testing equipment, ... of flat sheet membranes,” explains Sterlitech President Mark Spatz. ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2
... will be held Feb. 11-13 at the Waldorf-Astoria Hotel in New York ... ... YORK, Jan. 24 Gerson Lehrman Group (GLG) and the,Biotechnology Industry Organization ... information and,insights at the tenth annual BIO CEO & Investor Conference., ...
... Structure Synthesized,in the Lab, Team Completes Second Step ... Md., Jan. 24 A team of 17,researchers at ... largest,man-made DNA structure by synthesizing and assembling the 582,970 ... work, published,online today in the journal Science by Dan ...
... biostability company,that offers innovative technologies for stabilizing biological ... RNA at room,temperature, eliminating the need for cold ... skyrocketed over the past years due to its ... studies. However, RNA samples are,difficult to work with ...
Cached Biology Technology:Gerson Lehrman Group Announces Partnership With BIO to Provide Scientific Expertise for the BIO CEO & Investor Conference 2Gerson Lehrman Group Announces Partnership With BIO to Provide Scientific Expertise for the BIO CEO & Investor Conference 3Venter Institute Scientists Create First Synthetic Bacterial Genome 2Venter Institute Scientists Create First Synthetic Bacterial Genome 3Venter Institute Scientists Create First Synthetic Bacterial Genome 4Venter Institute Scientists Create First Synthetic Bacterial Genome 5Venter Institute Scientists Create First Synthetic Bacterial Genome 6Biomatrica's RNAstable(TM) Stabilizes RNA at Room Temperature 2Biomatrica's RNAstable(TM) Stabilizes RNA at Room Temperature 3
Rabbit Polyclonal antibody to Perilipin Applications: This antibody is useful for Western blot anlaysis where a band at ~60 kDa is seen....
Conveniently document gels, films and membranes with a high quality thermal printer. , Compact, footprint printer , Supplies 256 gray scale for high resolution, archive-quality thermal film prints...
... ICE-LAP3 Mch3 Lyophilized ... of enzyme regulation and kinetics, cleavage of target substrates, ... units/mg protein. One unit is defined as ... of Ac-DEVD-pNA Cat. No. 235400 per hour at 37 ...
HLA-DRbeta (DA2)...
Biology Products: