Navigation Links
Insight into DNA's 'weakest links' may yield clues to cancer biology

The chromosomes of mammals, including humans, contain regions that are particularly prone to breaking under conditions of stress and in cancer. Now, new research by geneticists at Duke University Medical Center finds that yeast cells also contain such weak links in DNA and begins to reveal the molecular characteristics of these links that might help to explain them.

The findings, published in the March 11, 2005, issue of Cell, suggest that yeast may offer a useful model system for studying the fundamental properties of so-called DNA fragile sites, providing new insight into the chromosomal instability found in cancer cells, said the researchers.

"If you look at solid tumors in humans, you see that the chromosomes of cancer cells exhibit incredible instability," said Thomas Petes, Ph.D., chair of genetics and microbiology at Duke. "Now, we have been able to mimic some of that instability in yeast cells and can begin to ask whether there is anything special that defines those places where chromosomes tend to break."

Organisms normally exhibit extremely low rates of mutation and chromosomal rearrangements. Conditions that elevate genomic instability lead to an increase in cell death and, in some cases, an increased incidence of cancer, Petes said.

Earlier work by other researchers had shown that mammalian chromosomes break at particular sites under certain types of stress or upon exposure to particular drugs, he said. Evidence has suggested that chromosomes break when DNA replication ?the process by which DNA copies itself before cell division ?slows or stalls. However, the DNA characteristics that make particular sites vulnerable to breakage had remained unclear, he said.

The researchers slowed DNA replication in yeast cells by reducing the availability of one form of DNA polymerase, which are enzymes critical in DNA duplication. Yeast with abnormally low levels of DNA polymerase exhibited higher frequencies of chromosomal loss a
'"/>

Source:Duke University Medical Center


Page: 1 2

Related biology news :

1. Fundamental Finding Yields Insight into Stem Cells, Cancer; Opens Door to Drug Discovery
2. New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines
3. Insight into natural cholesterol control suggests novel cholesterol-lowering therapy
4. Insight into our sight: A new view on the evolution of the eye lens
5. Insight into the processes of positive and negative learners
6. Large-scale Computer Simulations Reveal New Insights Into Antibiotic Resistance
7. What Makes The Brain Tick, Tick, Tick: Researchers Gaining New Insights Into Brains Internal Clock
8. Brown-Harvard team solves mobile DNAs surgical sleight-of-hand
9. Uncovering DNAs sweet secret
10. Genome-wide mouse study yields link to human leukemia
11. Microbial fuel cell: High yield hydrogen source and wastewater cleaner
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Insight into DNA weakest links may yield clues cancer biology

(Date:4/2/2015)... 2015 In the current ... outperforms the strongest competitors, showing outstanding performance in ... system is capable of a throughput of 5.000.000 ... to be ten times faster than most competitors ...      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ) ...
(Date:4/1/2015)... 2015   Medisafe ™, the leading global medication ... iOS and Android smartphones and tablets, ... the platform to allow patients to track and correlate ... time, patients will be able to visualize in real-time ... biometrics, such as glucose levels and blood pressure. ...
(Date:3/24/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) has ... Market 2015-2019" report to their offering. ... grow at a CAGR of 23.5 percent over the ... scenario and the growth prospects of the Global Iris ... market size, the report considers the revenue generated from ...
Breaking Biology News(10 mins):DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3Medisafe Announces Launch of Biometric Integration, Enabling Patients to Stay Adherent to Their Meds and See Tangible Health Results 2Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2
... This release is available in German . ... that Nadja Knoll found new proof in the nomad people of ... nutritionist from the Friedrich Schiller University Jena (Germany) analyzed the diet ... of the field study show that the Maasai are in a ...
... PROVIDENCE, R.I. [Brown University] In 1988, a mysterious invader ... likely arrived in ballast from commercial ships, and it found ... decades later, the crab, Hemigrapsus sanguineus , has expanded ... southward to North Carolina. Its numbers continue to expand, and ...
... ORLEANS, LA Broncus Technologies, Inc., a medical device ... diseases, announced today at the American Thoracic Society ... system version 2.1. The bronchoscopic navigation system is ... These highlight the clinical benefits of using the ...
Cached Biology News:Nomad people baffle with good health in spite of malnourishment 2Are invasives bad? Not always, say Brown researchers 2LungPoint system results presented at American Thoracic Society 2010 International Conference 2LungPoint system results presented at American Thoracic Society 2010 International Conference 3
(Date:5/1/2015)... Investor-Edge has initiated coverage ... GENE ), Agilent Technologies Inc. (NYSE: ... TMO ), Sequenom Inc. (NASDAQ: SQNM ), ... research report on Genetic Technologies can be accessed ... 2015, the NASDAQ Composite ended at 4,941.42, down ...
(Date:4/30/2015)... , April 30, 2015  Roka Bioscience, Inc. (NASDAQ: ... providing advanced testing solutions for the detection of foodborne ... the first quarter of 2015 on May 7, 2015 ... Roka Bioscience will also host a conference call at ... discuss its first quarter financial results. During the conference ...
(Date:4/30/2015)... 30, 2015 Oxford Finance LLC ("Oxford"), a ... sciences and healthcare services companies, today announced the closing ... with Celula, Inc., a diagnostic testing company focused on ... patient care and improved outcomes.  Proceeds of the loan ... the commercialization of its products in the U.S. and ...
(Date:4/30/2015)... MENLO PARK, Calif. , April 30, 2015 /PRNewswire/ ... company in the emerging field of regenerative medicine, today ... operating results on Thursday, May 7, 2015 after the ... host a conference call and webcast on Thursday, May ... Pacific to discuss the results and recent corporate developments. ...
Breaking Biology Technology:Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 2Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 3Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 4Life Sciences Tools and Services Stocks on our Radar -- Genetic Technologies, Agilent Technologies, Thermo Fisher Scientific, Sequenom, and PerkinElmer 5Roka Bioscience to Report First Quarter 2015 Financial Results On May 7, 2015 2Oxford Finance Provides $10 Million Debt Financing to Celula 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 2Asterias Biotherapeutics to Report First Quarter Results on May 7, 2015 3
... the late 1970s with the first IPOs taking place in 1980 ... 25 years old. , ,An interesting article in Genetic Engineering ... most industry cycles run about 50 years until they mature. If ... cycle. A new industry of significance usually produces an industrial revolution, ...
... the Digital Healthcare Conference 2005 on choosing ... technology. , ,For the Froedtert & Medical College ... other systems is simply one way, albeit a powerful ... ,"Research is our mission, and technology can help us ...
... Wis. Representatives of the British Consulate-General, ... health technology investments, met Wisconsin companies on Tuesday ... , ,"We're looking for companies with complimentary products ... for the Chicago office of the British ...
Cached Biology Technology:Biotech industry reaches midpoint in 50-year maturation cycle 2Biotech industry reaches midpoint in 50-year maturation cycle 3Biotech industry reaches midpoint in 50-year maturation cycle 4Biotech industry reaches midpoint in 50-year maturation cycle 5Rodney Dykehouse of Froedtert and Medical College of Wisconsin warns against tech for its own sake 2Rodney Dykehouse of Froedtert and Medical College of Wisconsin warns against tech for its own sake 3British, Wisconsin firms explore life-science opportunities together 2British, Wisconsin firms explore life-science opportunities together 3
Mouse monoclonal [HL-37] to HLA DQ1 + HLA DQ3 ( Abpromise for all tested applications)....
SHEEP ANTI BOVINE BETA-LACTOGLOBULIN A...
... Features Convenient platform for tube handling and ... x 0.2ml V-bottom tubes - 96 ... - Thermo-Fast® 96 Non-Skirted Plate ... - 48 x 0.5ml Thermo-Tubes Multiple workstations can ...
6B9...
Biology Products: