Navigation Links
Innovative smallpox vaccine research study to be conducted at Case Medical Center

University Hospitals Case Medical Center (UHCMC) and Case Western Reserve University School of Medicine are part of a nationwide research study to determine the safety and effectiveness of a new smallpox vaccine geared toward adults ages 18 to 34 who have never been vaccinated against the disease. The study is the first of its type in Northeast Ohio.

The current FDA-approved vaccine, Dryvax®, is not recommended for use on everyone because of the potential for serious side effects in certain individuals. “For example, the current vaccine cannot be used in immune-compromised individuals, such as patients with HIV or individuals with certain skin conditions such as eczema,” says Robert A. Salata, M.D., chief of the Division of Infectious Diseases at Case Western Reserve University School of Medicine and UHCMC.

The new vaccine, IMVAMUNE®, is different from Dryvax® in that it contains a more weakened form of the live-virus within the vaccine.

“Because the vaccine is weakened, the side effects should be minimized enough to give the vaccine to all individuals, even those whose immune systems are suppressed,” says Dr. Salata. “Our hope is that the new vaccine will be a safer alternative to the current vaccine.”

UHCMC and the School of Medicine will act as a subunit of St. Louis University’s Center for Vaccine Development, which is one of seven national testing sites known as Vaccine and Treatment Evaluation Units (VTEUs), designated by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.

The research study, which is actively recruiting and begins here June 15, will follow 215 volunteers nationwide over a two-year period. Volunteers must be in general good health and must not have previously been vaccinated against smallpox.

Smallpox is a contagious and sometimes fatal infectious disease characterized by raised bumps that appear on the face and body of an infected person. There is no specific treatment for smallpox disease, and the only prevention is vaccination. The World Health Organization declared the disease eradicated in 1980 with the success of a worldwide vaccination program. Routine vaccination against smallpox among the general public was ceased in 1972 because it was no longer necessary for prevention. However, recent threats of bioterrorism after 9/11 have spurred the development of a new safer vaccine that can be given to immune-compromised individuals.
'"/>

Source:Case Western Reserve University


Related biology news :

1. Innovative collaboration brings Arctic science into the classroom
2. Innovative coating could give medical implants a longer life
3. Innovative method for creating a human cytomegalovirus vaccine outlined
4. Innovative movies show real-time immune-cell activity within tumors
5. Stopping smallpox in its tracks: A new anti-viral approach
6. Secret of smallpoxs success may lead to bioterror cure
7. LIAI scientists make major finding on potential smallpox treatment
8. Researchers develop new testing methods for potential monkeypox or smallpox outbreak
9. Serious adverse reactions to smallpox vaccine appear to be limited
10. Mice studies illustrate potential of chimp/human antibodies to protect against smallpox
11. Defective immune system response to smallpox vaccine detailed in new study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/15/2016)... -- --> --> According ... "Digital Door Lock Systems Market - Global Industry Analysis, Size, ... digital door lock systems market in terms of revenue was ... to grow at a CAGR of 31.8% during the period ... (MSMEs) across the world and high industrial activity driving inclusive ...
(Date:3/11/2016)... , March 11, 2016 ... market research report "Image Recognition Market by Technology (Pattern ... and Advertising), by Deployment Type (On-Premises and Cloud), by ... 2022", published by MarketsandMarkets, the global market is expected ... USD 29.98 Billion by 2020, at a CAGR of ...
(Date:3/9/2016)... PALM BEACH GARDENS, Fla. , March 9, ... of identity management authentication and enrollment solutions, today ... proven DigitalPersona ® Altus multi-factor ... enable IT and InfoSec managers to step-up security ... friction.  Washington, DC ...
Breaking Biology News(10 mins):
(Date:5/6/2016)... ... May 06, 2016 , ... ... release, Clinical Studio Version 4.1, greatly improves performance of the platform. In particular, ... often generate tremendous volumes of data to be collected on a per patient ...
(Date:5/5/2016)... ON (PRWEB) , ... May 05, 2016 , ... ... following the previously announced identification of its first three targets, it has identified ... misfolded Amyloid beta (Aß), implicated in the development and progression of Alzheimer’s disease ...
(Date:5/4/2016)... New York, NY (PRWEB) , ... May 04, 2016 , ... ... neurofibromatosis (NF), a genetic disorder that causes tumors to grow on nerves throughout the ... treatment or cure. , Through numerous community events held during the month of May, ...
(Date:5/3/2016)... San Francisco, CA (PRWEB) , ... May 03, ... ... Morf Playbook™ enterprise talent development, skill-building and compliance training platform on ... Direct training course: Overview of Regulatory Requirements for Medical Devices. The course ...
Breaking Biology Technology: