Navigation Links
Innovative coating could give medical implants a longer life

By mimicking an adhesive protein secreted by mussels and a polymer that repels cells and proteins, researchers at Northwestern University have designed a versatile new two-sided coating that could breathe life into medical implants.

Currently the longevity of certain medical implants suffers because bacteria, cells and proteins in the body gradually accumulate on the devices (known as fouling), compromising their performance and threatening patients with infections. Unfortunately, the polymers that studies have shown to be effective at antifouling do not last long in-vivo, falling prey to chemical degradation or to the body's enzymes.

In contrast, the molecular compound developed at Northwestern, which sticks securely to a surface and prevents cell and protein buildup, works for a long period of time. In laboratory studies, the new coating provided effective fouling resistance for more than five months, which Phillip B. Messersmith, associate professor of biomedical engineering in the McCormick School of Engineering and Applied Science and lead investigator in the study, believes to be the longest successful in-vitro antifouling demonstration.

The findings are published online today (May 13) by the Journal of the American Chemical Society, a peer-reviewed publication of the American Chemical Society, the world's largest scientific society.

While the coating has not been tested in humans, it holds promise for use on a variety of medical implants including urinary catheters, cardiac stents, biosensors and dental implants and devices. The coating also could be used to prevent the biofouling of water processing equipment, ship hulls and other manmade structures in the marine environment.

Looking for a solution to the longevity problem in existing coatings, Messersmith teamed up with Annelise Barron, associate professor of chemical and biological engineering and an author on the paper. Barron is an expert at creating peptoids -- syn thetic molecules that are closely related to the natural proteins or peptides they mimic but don't degrade in the body.

Messersmith and Barron wanted to use this durability of peptoids to the antifouling coating's advantage. They proceeded to intelligently design a new polymer made up of two parts, both playing a key role: a short peptide that is the synthetic version of the sticky dihydroxyphenylalanine (DOPA) molecule that gives mussels their adhesive or anchoring strength and a longer peptoid polymer resembling the structure of polyethylene glycol (PEG), a widely studied antifouling polymer.

"We had a rich chemistry available to us when designing this polymer," said Messersmith. "The chemical characteristics of the antifouling component are similar to polyethylene glycol but it lasts longer because it is a peptoid and enzyme resistant. Plus, the structure of the polymer's backbone, which is based on a natural peptide, should make it very biocompatible and prevent evoking an immune response in the body."

The researchers tested their coating on titanium dioxide (a material common in medical implants) in environments that simulated physiologic conditions with fresh serum and cells. The coating anchored itself firmly to the surface and demonstrated excellent resistance to proteins and cells during the five-month experiment. For the same reason the coating is cell and protein resistant, it should also prove to be bacteria resistant, Messersmith said.


Source:Northwestern University

Related biology news :

1. Innovative collaboration brings Arctic science into the classroom
2. Innovative method for creating a human cytomegalovirus vaccine outlined
3. Innovative movies show real-time immune-cell activity within tumors
4. Aloe vera coating may prolong freshness, safety of fruits and vegetables
5. Antibacterial coatings cut infection rates
6. Edible coatings will be the packaging of the future
7. Protein discovery could unlock the secret to better TB treatment
8. Tiny particles could solve billion-dollar problem
9. First atlas of key brain genes could speed research on cancer, neurological diseases
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
Post Your Comments:

(Date:3/31/2016)... March 31, 2016   ... or the "Company") LegacyXChange is excited to ... its soon to be launched online site for trading ... ) will also provide potential shareholders a sense ... technology to an industry that is notorious for fraud. ...
(Date:3/29/2016)... , March 29, 2016 ... "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased to ... ink used in a variety of writing instruments, ensuring ... of originally created collectibles from athletes on LegacyXChange will ... analysis of the DNA. Bill Bollander ...
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... innovative medical technologies, services and solutions to the healthcare market. The company's primary ... various distribution, manufacturing, sales and marketing strategies that are necessary to help companies ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
Breaking Biology Technology: