Navigation Links
Injection may prevent infertility in men receiving cancer chemotherapy

It may be possible to protect the testes of cancer patients against the loss of fertility caused by chemotherapy, a scientist told the 22nd annual conference of the European Society of Human Reproduction and Embryology in Prague, Czech Republic on Tuesday 20 June 2006. Mr. Alon Carmely from Bar-Ilan University, Ramat Gan, Israel, said that his work showed for the first time that the injection of a drug that enhances the immune system could protect the testis from the effects of paclitaxel (Taxol), a widely used chemotherapy drug.

"The effects of chemotherapy treatment on fertility are an important issue for long-term survivors of cancer who may not have started or completed a family at the time of diagnosis", said Mr. Carmely. "AS101 is a Tellurium-based non-toxic immunomodulatory compound developed and synthesised by us. Tellurium is a transition element with similar properties to Selenium, which is also known to have many beneficial effects."

Knowing that AS101 had been shown to have chemoprotective effects in both animal and human studies, he and his team decided to investigate whether it could be used to avoid testicular damage in mice treated with Taxol. "Clinical studies had already shown that AS101 could protect against bone marrow damage and hair loss, and also sensitises the tumour to treatment", he said.

The scientists divided the mice into four groups ?Taxol only, AS101 plus Taxol, AS101 only, and a control group. After 30 days they were euthanized and their testes examined and weighed. The researchers found that a single dose of Taxol had induced significant testicular weight loss compared with the control group. An injection of AS101 a day before that of Taxol prevented the Taxol-induced weight loss.

"Tissue analysis of the testes of Taxol-injected mice showed severe atrophy and empty seminiferous tubules, where the sperm-producing cells are contained", said Mr. Carmely. "In contrast, we saw only minimal testi cular damage in the group that had previously been injected with AS101, and we could also find mature sperm. Injection of AS101 alone did not alter testicular weight or tissue analysis results.

"These results hold out much promise for fertility preservation in men undergoing cancer treatments", he said. "We now intend to study the mechanism of protection, which is still unclear. Our work suggests that in addition to the direct damage caused by the treatment, significant testicular damage is caused by the immune reaction to it. We hope to begin clinical studies in cancer patients in the next few months."


'"/>

Source:European Society for Human Reproduction and Embryology


Related biology news :

1. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
2. Antiretroviral therapy may prevent excess risk of some cancers in people with HIV
3. Rare surgery performed to remove pancreas, prevent diabetes
4. Protein prevents detrimental immune effects of bacterial sepsis
5. Understanding how bacteria communicate may help scientists prevent disease
6. Does vitamin C help prevent or treat the common cold? Maybe not, after all.
7. Late peak may have prevented severe flu season from becoming worse
8. A protein in the eye may prevent immune response and protect eyes from disease
9. Why were the HIV prevention trials in commercial sex workers abandoned?
10. President Bushs cut to AIDS prevention in Africa would be devastating
11. Chemical band-aid prevents heart failure in mice with muscular dystrophy
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:3/30/2017)... -- On April 6-7, 2017, Sequencing.com will host the world,s ... at Microsoft,s headquarters in Redmond, Washington ... health and wellness apps that provide a unique, personalized ... is the first hackathon for personal genomics and the ... the genomics, tech and health industries are sending teams ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. 11, ... Research, London (ICR) and University of ... SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma (MM), ... nine . The University of Leeds ... funded by Myeloma UK, and ICR will perform the testing ...
(Date:10/10/2017)... Angeles, CA (PRWEB) , ... ... ... Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) therapeutics, ... uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed in ...
(Date:10/10/2017)... BARBARA, CALIFORNIA (PRWEB) , ... October 10, 2017 ... ... management, technological innovation and business process optimization firm for the life sciences and ... BoxWorks conference in San Francisco. , The presentation, “Automating GxP Validation ...
(Date:10/9/2017)... ... October 09, 2017 , ... The Giving Tree Wellness Center ... the needs of consumers who are incorporating medical marijuana into their wellness and ... , As operators of two successful Valley dispensaries, The Giving Tree’s two founders, ...
Breaking Biology Technology: