Navigation Links
Inheritance outside DNA

Most people have heard that human inheritance is spelled out in our DNA and activated through our genes. Yet few know anything about epigenetics, a variety of methods that our cells have evolved to transmit heritable changes without changing DNA.

Among other things, epigenetics is crucial to differentiation, the process which makes one cell from another, and thus is at the heart of the mystery of stem cells.

Genomic imprinting is a type of epigenetic change that causes one copy of a particular gene to be turned off, depending on its parental origin. It works largely by altering the methylation patterns"the addition or subtraction of methyl groups"around a gene, but not the DNA sequence itself. These methylation patterns are reprogrammed when passed from generation to generation, carrying instructions related to the parent from whom that copy was inherited but without altering the DNA.

Abnormal methylation patterns in cancerous cells were discovered more than 20 years ago. Yet tumor cells have so many things wrong with them, including methylation abnormalities, that a precise cause-and-effect relationship between cancer and epigenetic alterations has been difficult to pin down, says Andrew Feinberg of the John Hopkins School of Medicine, who has been a pioneer in unraveling the epigenetics of cancer.

Now Feinberg has taken a new look at genomic imprinting, as a cancer-predisposing factor. Feinberg analyzed a common epigenetic alteration—found in 5?0 percent of the general population—that involves the loss of imprinting on an insulin-like growth factor gene called IGF2. Loss of imprinting of IGF2 has been associated statistically with individuals who have personal and familial histories of colorectal cancer. Turning to mice that modeled the loss of IGF2 imprinting, Feinberg found an increase in frequency of tumors in mice who also had mutations in a cancer-associated gene called Apc. In the mutant Apc mice, the loss of IGF2 im
'"/>

Source:American Society for Cell Biology


Page: 1 2

Related biology news :

1. Maine Researchers Find Exceptions to Old Rules of Genetic Inheritance
2. Living taste cells produced outside the body
3. Bacteria have their own immune system protecting against outside DNA
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Inheritance outside DNA

(Date:9/16/2014)... "molecular brakes" that time the generation of important cells ... cells" translate sound waves into electrical signals that are ... If the arrangement of the cells is disordered, hearing ... will be published in The Journal of Neuroscience ... Hey2 act as brakes to prevent hair cell generation ...
(Date:9/16/2014)... make us sick can take up residence in and ... or other troublesome symptom, according to new research at ... , On average, healthy individuals carry about five types ... in BioMed Central Biology . The study is ... viruses in healthy people. , The research was ...
(Date:9/16/2014)... chunk of rock hit the Yukatan peninsula near the site ... 100 teratons of TNT. It left a crater more than ... and volcanism are widely accepted to have wiped out the ... But what happened to the plants on which the dinosaurs ... University of Arizona reveals that the meteorite impact that spelled ...
Breaking Biology News(10 mins):Hey1 and Hey2 ensure inner ear 'hair cells' are made at the right time, in the right place 2Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3Meteorite that doomed the dinosaurs helped the forests bloom 2Meteorite that doomed the dinosaurs helped the forests bloom 3
... - Primary Energy Recycling Corporation (TSX: PRI), (the "Company") a clean energy company ... announced its financial and operational results for the first quarter ended March ... Highlights for the ... 4.3% for the three months ended March 31, 2010, ...
... Spain and the UK have identified the final piece in ... Published today by PNAS, the breakthrough discovery by the Consejo ... of East Anglia (UEA) has implications for agribusiness, the environment ... deposit which accumulates in the seeds, beans and tubers of ...
... cystic fibrosis can be caused by genetic "nonsense mutations" ... Bedwell, Ph.D., a professor in the University of Alabama ... now closer to producing drugs that will fix this ... Bedwell is a renowned researcher on the select group ...
Cached Biology News:Primary Energy Reports Improved First Quarter Results 2Primary Energy Reports Improved First Quarter Results 3Primary Energy Reports Improved First Quarter Results 4Primary Energy Reports Improved First Quarter Results 5Scientists discover final piece in phytate jigsaw 2Drug may treat cystic fibrosis, other diseases caused by 'nonsense mutations,' UAB researcher says 2
(Date:9/16/2014)... From cell phones to cars and flashlights, ... Scientists and technology companies constantly are seeking ways ... the first time using a water-based solution, researchers ... long-lasting and more efficient nuclear battery that could ... reliable energy source in automobiles and also in ...
(Date:9/16/2014)... CHAPEL HILL, N.C. , Sept. 16, 2014 /PRNewswire/ ... its experimental heart failure compound has been shown to ... The preclinical results demonstrate an alternative to intravenous infusions ... with HNO prodrugs. The data were presented yesterday at ... Annual Scientific Meeting in Las Vegas ...
(Date:9/16/2014)... , Sept. 16, 2014  The Council ... entrepreneurial support organization in the country, today released ... Report . It showed that ... North Carolina startups in the technology, ... more global investment from a variety of sources. Significant ...
(Date:9/16/2014)... Convoy Therapeutics, Inc., a specialty ... to treat patients directly at the site of ... Technology Platform announced today that John Muraski, Ph.D., ... the White Hat Life Science Investor Conference™ on ... In addition, interested individuals can meet Convoy ...
Breaking Biology Technology:Cardioxyl Presents Oral Heart Failure Treatment Data For Its Experimental HNO Prodrug At HFSA 18th Annual Scientific Meeting 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 2CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 3CED's Mid-Year Update to its Innovators Report Shows NC Startups Attracting Investment From Across the Globe with Several High-Profile Investment Deals, IPOs and Acquisitions Signaling Strength of Entrepreneurial Sector 4Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 3
... To highlight its 20 years of experience as ... ( www.microtestlabs.com ) is offering free microbial identification ... tests, to eligible attendees visiting the Microtest exhibit, #828, ... highlight Microtest,s wide range of laboratory testing and validation ...
... RGEN ) announced today that the Company ... will present at the BIO CEO and Investor Conference ... at the Waldorf-Astoria Hotel, 301 Park Avenue, New York, ... available via Repligen,s website at www.repligen.com and ...
... Secretropin(R) , the first clinically proven natural stimulator of ... as a more desirable "first step" approach to pursuing ... Secretropin(R) is only available through ... to increase the body,s own production and release of ...
Cached Biology Technology:Microtest Labs Offers Free Microbial Identification Testing, Free Shipping on Other Tests, to MD&M West Attendees 2Repligen to Present at the BIO CEO & Investor Conference Monday, February 9th, 11:30 a.m. EST 2Secretropin(R) - Effective, Preferable, Affordable as an Alternative to Injectable Growth Hormone - Gains Momentum 2