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Inflammation markers identify fatigue in breast cancer survivors

of monocytes in the blood, and enables antigen presenting cells to activate T cells as part of the cellular immune response," Dr. Irwin said.

The second component of the marker is an index measured by the level of T cells that are characterized by CD69, a cell membrane protein that indicates early activation of those T cells. Patients with a decreased number of CD69+ T cells along with the high ratio of serum IL6R/monocyte-bound IL-6R were likely to experience persistent fatigue.

Battling breast cancer is a daunting challenge to women diagnosed with the disease, but with advanced screening and treatment strategies, patients with early stage breast cancer are surviving longer. Breast cancer survivors are the largest group of patients to overcome any type of cancer in the United States. While patients surviving other types of cancer also can experience the long-lasting fatigue syndrome, a greater proportion of breast cancer survivors endure the condition.

Cancer researchers had explored various possible reasons for the persistent fatigue in breast cancer survivors, Dr. Irwin said, such as different kinds of treatment, or biological events including anemia.

Dr. Irwin and his colleagues' research is the first to document an association between biological mechanisms involved with the immune response and persistent fatigue.

"It is such an important quality of life issue. Many patients are surviving from their cancer treatments, but they are surviving with substantial impairments in their ability to carry on their lives," Dr. Irwin said. "We've addressed the cancer in these survivors, and now we can also address the functional declines in the quality of life of these patients."

Dr. Irwin defined the fatigue biomarker in collaboration with Alicia Collado-Hidalgo, Julienne E. Bower, Patricia A. Ganz, and Steve W. Cole, with the David E. Geffen School of Medicine at UCLA.


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Source:American Association for Cancer Research


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