Navigation Links
Inflammation and drugs to control this activity studied in a variety of tumors sites

r or not they could use molecular tools, such as COX-2 levels, to predict who among the group of women with atypia would develop breast cancer and develop ways to separate groups of women into high risk and normal risk. The COX-2, or cyclooxygenase-2, enzyme is produced by the body when there is inflammation and is also produced by precancerous tissues.

They took advantage of a tissue bank from the Mayo Clinic Benign Breast Disease Cohort, which includes several thousand women who, between 1967 and 1991, had a benign breast biopsy. Of this group, 235 women had atypical hyperplasia and tissue available for the study. Cancer follow-up information was available for all of these women. Hartmann and her co-workers determined the amount of COX-2 in these samples by staining immunohistochemistry methods. Forty-one of the 235 women with atypia developed breast cancer over roughly a 15- to 20-year period.

The research team found a significantly higher level of COX-2 in atypias of those women who went on to develop breast cancer than they did in control subjects. "Intense COX-2 expression," Hartmann said, "is associated with a significantly greater likelihood of a subsequent breast cancer in women with atypia. Specifically, for women with strong staining, their risk of breast cancer at 20 years was 31 percent, versus 14 percent for those with negative or weak staining."

She noted that increased COX-2 expression has also been seen in an early form of breast cancer called ductal carcinoma in situ, or DCIS. Hartmann said that COX-2 represents a potential target for chemoprevention. Her team plans to expand the test group and will continue to profile women with atypia who did and who did not develop breast cancer in an attempt to identify early predictors of risk.

Reduction in the Risk of Human Breast Cancer by COX-2 Inhibitors: Abstract No. 2352

Results of a five-year study have shown for the first time a significant reduction in ri
'"/>

Source:American Association for Cancer Research


Page: 1 2 3 4 5 6 7 8 9

Related biology news :

1. How an AIDS-Related Cancer Unleashes Inflammation
2. Researchers Discover Gene That Determines Asthma Susceptibility By Regulating Inflammation
3. Inflammation markers identify fatigue in breast cancer survivors
4. Inflammation may play role in metastasis of prostate cancer
5. Molecular machine may lead to new drugs to combat human diseases
6. Researchers identify target for cancer drugs
7. MetaChip provides quick, efficient toxicity screening of potential drugs
8. Newly discovered pathway might help in design of cancer drugs
9. UNC launches study of liver injury caused by drugs
10. Findings have implications for tracking disease, drugs at the molecular level
11. Future diabetes drugs may target new protein interaction
Post Your Comments:
(Date:5/21/2013)... scientists have developed many devices that can reopen clogged ... effective, each of these treatments has drawbacks, including the ... MIT analyzes the potential usefulness of a new treatment ... stents, but may pose fewer risks. With this new ... only a brief period, during which it releases a ...
(Date:5/21/2013)... which alter the way genes function without changing ... in the blood of pregnant women during any ... depression in the weeks after giving birth, and ... , The findings of the small study involving ... journal Molecular Psychiatry . , "Postpartum depression ...
(Date:5/20/2013)... popularly known as the lungs of the planet, inhales carbon ... the air to grow parts that eventually fall to the ... plentiful rainfall. , Until recently people believed much of ... ended up deep in the ocean. University of Washington research ... carbon dioxide though left open the question of how ...
Breaking Biology News(10 mins):Evaluating a new way to open clogged arteries 2Evaluating a new way to open clogged arteries 3Genetic predictors of postpartum depression uncovered by Hopkins researchers 2Genetic predictors of postpartum depression uncovered by Hopkins researchers 3Amazon River exhales virtually all carbon taken up by rain forest 2Amazon River exhales virtually all carbon taken up by rain forest 3
... LA JOLLA, Calif., September 11, 2009 Dieter ... Medical Research (Burnham) have illuminated how competition between proteins ... proteins for destruction). Using S. pombe fission yeast as ... in which an array of Fbox proteins alternately attach ...
... Joseph,s Hospital and Medical Center has been awarded a $400,000 ... a rare cell type that is believed to play a ... this cell type have been seen in people suffering from ... A.D. "Bud" Craig, PhD, and other scientists in Barrow,s Atkinson ...
... types of fish we buy in stores or order in restaurants, ... higher than dying of natural causes. This may seem obvious to ... may not be apparent is that the relentless pursuit of consumer-friendly ... the world. By repeatedly choosing only the biggest fish, or only ...
Cached Biology News:When proteins change partners 2Changing the course of nature: Are fisheries directing the evolution of fish populations? 2
(Date:5/21/2013)... Alpha Source, Inc., a Wisconsin-based ... for the 13th consecutive year at the Association ... Conference and Expo. The conference brings together professionals ... technologies. This year’s event will be held from ... The three-day event draws over 1,500 healthcare technology ...
(Date:5/21/2013)... NJ (PRWEB) May 21, 2013 Savoury ... industry, has appointed Dale Braddy to Southeastern USA Sales ... bolster its sales muscle in the Southeast. ... food ingredient brokerage and supplier to food processors and ... 13 years in the food industry and has over ...
(Date:5/21/2013)... Smarter Security, Inc., provider of premium, innovative entrance ... a Sanofi company and leading biotech company, recently ordered ... multi-use facility in the United States. With Door Detective ... latest order underscores the satisfaction and success the company ... improving doorway access control. , “We recommend Door ...
(Date:5/21/2013)... (PRWEB) May 21, 2013 As ... a strong push within the industry to deliver ... Manufacturing Organizations and pharma companies often means turning ... , Microtablets, developed in collaboration with Sensidose AB ... outsourcing can bring products to market sooner. The ...
Breaking Biology Technology:Alpha Source, Inc. to Exhibit at the AAMI 2013 Conference and Expo 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 2Door Security at Genzyme, a Sanofi Company, Enhanced with Door Detective from Smarter Security 3The Development of an Innovative Microtablet Dosage Form, a Success Story: Live Webinar Hosted by Xtalks 2
... , ROCKVILLE, Md. , Feb. 5 Novavax, ... Dr. Rahul Singhvi , President and Chief Executive Officer of Novavax ... on February 8th, 2010 at 10:00 am local ... CEO & Investor Conference will take place February 8-9 at ...
... and a bit of high-grade plastic draws oil out of contaminated ... that oil absorbed can be squeezed back out for use. ... an aerogel, believe it will effectively clean up spills of all ... and oceans. , The EPA estimates that 10 to 25 million ...
... , DENVER , Feb. 4 ... leading employment communities for the hospitality and healthcare industries, are ... and job seekers. , (Photo: http://www.newscom.com/cgi-bin/prnh/20100204/FL49504LOGO-a ) , ... chosen Hcareers for the User,s Choice Award three times since ...
Cached Biology Technology:NOVAVAX to Present at the 12th Annual BIO CEO & Investor Conference 2New material absorbs, conserves oil 2Industry Web Sites Continue to Win Online Award 2Industry Web Sites Continue to Win Online Award 3
Verotoxin IIbeta (457)...
Features , Designed to assist users in applying domed caps to tube strips and plates , Minimises the pressure required to seal the caps effectively , Enables multiple tubes to be sealed simultaneousl...
Request Info...
Sterile, individually wrapped, 4mm Cuvettes...
Biology Products: