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Inflammation and drugs to control this activity studied in a variety of tumors sites

yzed 84 subsequent biopsies performed within five years in patients who had initially shown chronic prostate inflammation. In the follow up, 29 new cancer cases were diagnosed: six occurred in patients in whom initial biopsies showed only chronic inflammation, 15 in patients with initial PAH/PIA lesions, along with eight in patients with chronic inflammation and other risk factors for cancer (high-grade prostate intraepithelial neoplasia and atypical small acinar proliferation that may have been cancerous).

In contrast, the researchers found only two cases ?six percent ?in the 33 patients without inflammation who went on to develop cancer, both of whom had other risk factors for cancer.

"We observed a significant association between serum PSA and the degree of chronic inflammation," said Gupta, which was expected based on previous findings.

"The first concern is, should patients with initial biopsies showing no malignancy but showing chronic inflammation be followed more closely and perhaps re-biopsied more frequently?" Gupta said.

Gupta's group plans future studies that will be similar in design, but have a larger number of subjects.

COX-2 Expression in Atypia: Correlation with Breast Cancer Risk: Abstract No. 2353

Women with atypical hyperplasia who also have high levels of the enzyme COX-2 in their breast tissue were more likely to develop breast cancer than women with lower levels of the enzyme.

According to Lynn Hartmann, M.D., professor of oncology at the Mayo Clinic College of Medicine in Rochester, Minn., about one million women a year have a breast biopsy with benign findings (sometimes called benign breast disease). One form of benign breast disease, atypical hyperplasia, or atypia, is characterized by abnormal cell growth and can be precancerous. Women with this condition have a four times greater risk of developing breast cancer.

Hartmann and her co-workers wanted to find out whethe
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Source:American Association for Cancer Research


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