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Inflammation and drugs to control this activity studied in a variety of tumors sites

dual response to inflammatory stimuli may increase or decrease a person's risk of developing a brain tumor," Scheurer said.

Influence of Chronic Inflammation on Prostate Carcinogenesis: A Five-Year Follow-up Study: Abstract No. 1474

Researchers at Case Western Reserve University in Cleveland have evidence linking chronic inflammation in the prostate to a greater risk of developing prostate cancer. Results of repeat biopsies of prostate tissue over a five-year period from men who had abnormal serum prostate specific antigen (PSA) levels and/or digital rectal examinations (DRE) suggest that chronic inflammation may be a significant risk factor in the development of prostate cancer.

While connections between inflammation and cancer have been shown for some cancers, no one had shown a relation between chronic prostate inflammation and the development of prostate cancer, said Sanjay Gupta, Ph.D., assistant professor of urology at Case Western Reserve University in Cleveland, who led the work along with Greg MacLennan, M.D., associate professor of pathology.

Gupta and his co-workers examined the results of prostate needle biopsies from 177 men between ages 47 and 83 years who were at high risk for developing cancer based on either high PSA scores or abnormal DREs. Of the 177 men, 144 or 81 percent were found to have chronic prostate tissue inflammation.

The scientists categorized the biopsies based on pathology. They found that of the 144 cases, 15 percent (22/144) had only inflammation, 15 percent (22/144) had simple atrophy, 39 percent (54/144) showed PAH/PIA (post-atrophic hyperplasia and/or proliferative inflammatory atrophy, which indicate evidence of chronic inflammation) lesions, and eight percent, or 12/144, showed HGPIN ?high-grade prostate intraepithelial neoplasia, which is a precursor to prostate cancer. About 20 percent, or 29/144, had cancer (adenocarcinoma) in the initial biopsies.

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Source:American Association for Cancer Research


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