Navigation Links
Infection 'alarm' yields clues to immune system behavior

ry a message about this health threat to neighboring blood vessel cells, asking them to join in the fight. To send this message, a TNF molecule latches onto the surface of a neighboring cell and accesses a biological information highway called the NF-kappaB pathway. Via a series of chemical reactions that act like signals traveling over a telephone wire, TNF's message moves along this pathway from the cell's surface to its nucleus.

At the end of this pathway, NF-kappaB molecules are released to carry the alarm into the nucleus, the cell's control center. Inside the nucleus, the NF-kappaB molecules switch on genes that produce infection-fighting proteins. These proteins launch several strategies to fight the microscopic invaders, such as sending more white blood cells to engulf the bacteria or toxins. The proteins also set off a response known as inflammation, characterized by redness, swelling and pain.

In their journal article, Levchenko and his colleagues reported several important new discoveries about this cellular signaling system. "You could think of the TNF molecule, which sounds the alarm, as a very weak radio transmitter. It moves very slowly as it carries its warning message to neighboring cells, so it is unable to send that message over long distances," Levchenko said. "However, we discovered that the cellular pathways that pick up this signal act like extremely sensitive radio receivers. They can pick up the alarm message from exposure to even a very small amount of TNF. This turns out to be a very smart strategy on the part of the cells."

He explained that a pricked finger usually generates a very localized fight against infection, involving only nearby cells. If TNF's signal was strong enough to set off an immune response involving the entire body, the result could be a high fever and septic shock. "We've developed a better understanding of why the fight against a local infection stays local," said Raymond Cheong, a graduate stu
'"/>

Source:Johns Hopkins University


Page: 1 2 3

Related biology news :

1. HIV Infection Still On The Rise
2. Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
3. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
4. Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure
5. Infections could contribute to adult brain tumours
6. Infection detectives use disease fingerprints to track common infections in children
7. Genome-wide mouse study yields link to human leukemia
8. Marine sponge yields nanoscale secrets
9. Small worm yields big clue on muscle receptor action
10. Organic farms produce same yields as conventional farms
11. GM crop that holds on to its seeds offers higher yields
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Infection alarm yields clues immune system behavior

(Date:12/17/2014)... , Dec. 16, 2014  Automation is fundamentally ... more evident than at international borders. Over the ... scanners have allowed veteran travelers to self process ... Control (APC) Kiosks at an increasing number of ... According to Maxine Most ...
(Date:12/11/2014)... 2014  Data Sciences International (DSI), the global ... new series of digital telemetry implants to meet ... series, part of the PhysioTel™ Digital platform, was ... physiologic data when incorporating functional endpoints into repeat-dose ... toxicology studies has evolved from short ECG strips ...
(Date:12/10/2014)... Dec. 08, 2014 Research and Markets ... of the "Biometrics Market in Japan 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 The integration ... as rural banking and upgradation of the driver,s ... in the market. Besides the aforementioned projects, biometrics ...
Breaking Biology News(10 mins):Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2New telemetry implants expected to change how large animal toxicology studies are conducted 2Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2
... study by Nanyang Technological University (NTU),s Assistant Professor Li ... team have made an important contribution to the understanding ... die. This process known as ,apoptosis, or programmed cell ... which removes perhaps a million cells a second. ...
... Nanostructured materials have garnered great interest worldwide due ... structural, medical and consumer applications. Singapore,s ... a new environmentally friendly method to synthesize a ... synthesis has been recently published in Nature ...
... (NOAA) today published a final rule in the Federal Register ... (EEZ) off the coasts of California, Oregon, and Washington. ... Krill are a small shrimp-like crustacean and a key ... are the foundation for a healthy marine ecosystem," said Mark ...
Cached Biology News:Study by NTU professors provides important insight into apoptosis or programmed cell death 2Facile synthesis of nanoparticles with multiple functions advanced in Singapore 2NOAA bans commercial harvesting of krill 2
(Date:12/22/2014)... December 22, 2014 The Center ... leader of technical training across the life sciences industry, ... Management (SCDM) to provide the organization's members with ... —providing access to the more than 350 sessions across ... with 10% off when registering for a public ...
(Date:12/22/2014)... -- GenomeDx Biosciences today announced that a new study ... test for prostate cancer, was able to predict rapid ... prostatectomy without adjuvant therapy. Although rapid metastasis in men ... genomics to identify these men who have a highly ... The study has been published online by the ...
(Date:12/22/2014)... TENN (PRWEB) December 22, 2014 Fertility ... Donor Egg Bank USA , a network of ... country. Through this partnership, patients have fast access to ... in vitro fertilization, IVF . Fertility Associates of Memphis ... offer this fertility treatment option. , Dr. William ...
(Date:12/19/2014)... , Dec. 19, 2014 Naurex Inc., ... novel drugs for diseases of the central nervous system, ... and chief executive officer, will present at the 33 ... presentation will take place at 3:00 p.m. PST on ... in San Francisco, Calif. ...
Breaking Biology Technology:CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 2Fertility Associates of Memphis Announces Partnership with Donor Egg Bank USA 3Naurex to Present at 33rd Annual J.P. Morgan Healthcare Conference 2
... and Funding Barriers and Paves Way ... for Affordable and Efficient Approach, KAKAMEGA, Kenya, ... and HIV was launched today in the Western,Kenyan district of ... a basic care package consisting of a,PermaNet(R) long-lasting insecticide-treated bed ...
... Institutional Investors to Attend Conference, MONTREAL, Sept. ... today announced that Mr. Pierre Laurin, President,and Chief ... 5th,annual Investor Summit on September 16, 2008 at ... Mark Hopkins InterContinental Hotel in San Francisco., ...
... Calif., Sept. 12 Acologix, Inc., a privately,held ... studies demonstrating that AC-100, its therapeutic product,candidate derived ... and,dental cells, promotes cartilage regeneration in large animal ... A. Middleton-Hardie on September,13, 2008 at the 30th ...
Cached Biology Technology:Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease 2Integrated Prevention Demonstration Campaign Launched in Western Kenya to Fight HIV, Malaria and Diarrhoeal Disease 3ProMetic to present at Merriman Curhan Ford's Investor Summit 2008 on September 16th 2Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting 2Acologix Presents Preclinical Data on Cartilage Regeneration by AC-100 at the 30th ASBMR Annual Meeting 3
... next step in the evolution of laboratory ... that delivers labware to multiple laboratory instruments, ... the throughput of ordinary microplate robots. It ... of configurations to meet any labs specific ...
... applications for the use of small interfering ... via the RNA interference (RNAi) pathway have ... molecular biology fields. siRNA for experimental use ... or enzymatically, and then transfected into the ...
... S&S Custom Array Service enables scientists who have ... to have FAST Slides printed with proteins from ... Processing of the arrays is performed by the ... S&S to discuss your needs with an expert ...
... The high-performance triple quadrupole 1200L ... in today's cost-conscious environment - incorporating ... solutions for all liquid chromatography analytical ... (API) interface and the Transmission Quadrupole ...
Biology Products: