Navigation Links
Infection 'alarm' yields clues to immune system behavior

ry a message about this health threat to neighboring blood vessel cells, asking them to join in the fight. To send this message, a TNF molecule latches onto the surface of a neighboring cell and accesses a biological information highway called the NF-kappaB pathway. Via a series of chemical reactions that act like signals traveling over a telephone wire, TNF's message moves along this pathway from the cell's surface to its nucleus.

At the end of this pathway, NF-kappaB molecules are released to carry the alarm into the nucleus, the cell's control center. Inside the nucleus, the NF-kappaB molecules switch on genes that produce infection-fighting proteins. These proteins launch several strategies to fight the microscopic invaders, such as sending more white blood cells to engulf the bacteria or toxins. The proteins also set off a response known as inflammation, characterized by redness, swelling and pain.

In their journal article, Levchenko and his colleagues reported several important new discoveries about this cellular signaling system. "You could think of the TNF molecule, which sounds the alarm, as a very weak radio transmitter. It moves very slowly as it carries its warning message to neighboring cells, so it is unable to send that message over long distances," Levchenko said. "However, we discovered that the cellular pathways that pick up this signal act like extremely sensitive radio receivers. They can pick up the alarm message from exposure to even a very small amount of TNF. This turns out to be a very smart strategy on the part of the cells."

He explained that a pricked finger usually generates a very localized fight against infection, involving only nearby cells. If TNF's signal was strong enough to set off an immune response involving the entire body, the result could be a high fever and septic shock. "We've developed a better understanding of why the fight against a local infection stays local," said Raymond Cheong, a graduate stu
'"/>

Source:Johns Hopkins University


Page: 1 2 3

Related biology news :

1. HIV Infection Still On The Rise
2. Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
3. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
4. Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure
5. Infections could contribute to adult brain tumours
6. Infection detectives use disease fingerprints to track common infections in children
7. Genome-wide mouse study yields link to human leukemia
8. Marine sponge yields nanoscale secrets
9. Small worm yields big clue on muscle receptor action
10. Organic farms produce same yields as conventional farms
11. GM crop that holds on to its seeds offers higher yields
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Infection alarm yields clues immune system behavior

(Date:7/23/2014)... , , , , ... , , , , ... extend healthy lifespan. The idea, they argue, would be to target the... , , ... , , , , , ... , , , , , , , Medicine focuses almost ...
(Date:7/23/2014)... has the entire country in its grip is affecting more ... responsible for the proliferation of a heat-loving amoeba commonly found ... springs, which the drought has made warmer than usual this ... infection caused by this parasite after swimming in several area ... an individual and travels to the brain. Nose plugs can ...
(Date:7/23/2014)... The planet,s soil releases about 60 billion tons of ... more than that released by burning fossil fuels. This ... release of carbon is balanced by carbon coming into ... matter, as well as by the underground activities of ... that rising temperatures increase the rate of soil respiration. ...
Breaking Biology News(10 mins):Strategy proposed for preventing diseases of aging 2Strategy proposed for preventing diseases of aging 3Strategy proposed for preventing diseases of aging 4Strategy proposed for preventing diseases of aging 5Diseases of another kind 2Climate change and the soil 2
... are ineffective and their continuation endangers ecosystems that ... worlds population depend, United Nations University experts warn ... for sweeping change. In a blunt assessment, ... Headquarters, New York, UNUs Canadian-based International Network on ...
... Biologist John Smol has been named as one of ... Royal Canadian Geographical Society. His half-brother, biologist Jules Blais, ... one of Canada,s most prestigious in the environmental sciences. ... work to Canadian society. Smol is series ...
... Atmel(R) Corporation (Nasdaq:,ATML), an inventor and leading ... that its FingerChip(R) fingerprint sensor,solution has been selected ... PC.,Rise will showcase this biometrics-capable LCD PC during ... as a standard feature enhances consumer,friendliness in the ...
Cached Biology News:Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 2Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 3Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 4Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 5Coastal management cooperation, enforcement key to avoid pending crisis for millions: U.N. experts 6Atmel's FingerChip Biometric Sensor Selected by Rise Computer for its Robust Security 2Atmel's FingerChip Biometric Sensor Selected by Rise Computer for its Robust Security 3
(Date:7/22/2014)... July 21, 2014 (PRWEB) July 23, 2014 ... at Rutgers University. , The goal of ... across the full spectrum of scientists working in ... and development topics that represent the most promising ... programmed to:,     Provide faculty and ...
(Date:7/22/2014)... solution of rod-shaped metal nanoparticles in water with ultrasound ... drill bits. Why? No one yet knows exactly. But ... (NIST) have clocked their speedand it,s fast. At up ... times faster than any nanoscale object submerged in liquid ... has opened up the possibility that they could be ...
(Date:7/22/2014)... CTD Holdings, Inc. (OTCQB:CTDH), a manufacturer ... cosmetics, and other markets, announced today that it has ... qualified private investors led by Novit L.P., an investment ... transaction involved the signing of a Securities Purchase Agreement ... Stock at a price per share of $1.00, resulting ...
(Date:7/22/2014)... Two new members were elected to the University ... Shareholders Meeting on June 13: Kerry R. Benson, Managing ... and Stephen T. Zarrilli, President and CEO of Safeguard ... Michael A. DiPiano, Managing General Partner of New Spring ... Esq., of Duane Morris LLP, as Director Emeritus. , ...
Breaking Biology Technology:The 2014 NJ Symposium on Biomaterials Science Earns Society for Biomaterials Endorsement 2NIST shows ultrasonically propelled nanorods spin dizzyingly fast 2CTD Holdings Closes $1.725 Million Private Placement 2CTD Holdings Closes $1.725 Million Private Placement 3Two New Members Elected to University City Science Center Board of Directors 2Two New Members Elected to University City Science Center Board of Directors 3
... Va., June 20 Insmed Inc. (Nasdaq:,INSM), a ... it intends to request a hearing before The ... earlier Staff Determination,to delist the Company,s common stock ... a letter from The NASDAQ Stock Market ("NASDAQ") ...
... June 20, 2008 / b3c newswire / ... organization (CMO) for the development and production of ... 2,500 L multi-process production suite. Hence, Rentschler Biotechnologie ... of 30, 250, 500 and 2,500 liters, allowing ...
... InterMune, Inc.,(Nasdaq: ITMN ) today announced that ... InterMune, will present at the Jefferies 2nd,Annual Healthcare Conference ... p.m. EDT., To access a live audio webcast ... on to the investor relations page of InterMune,s,corporate website ...
Cached Biology Technology:Insmed to Request Hearing Before NASDAQ Panel to Review NASDAQ Staff Determination 2Rentschler Biotechnologie Extends Capacities for Mammalian Cell Culture Manufacturing 2
Request Info...
Services include subcloning into an expression vector. Tagged protein will be expressed in small scale for testing yield and solubility and then in 1L culture for large scale affinity purification. E...
Request Info...
...
Biology Products: