Navigation Links
Infection 'alarm' yields clues to immune system behavior

Drawing on lab experiments and computer studies, Johns Hopkins researchers have learned how a common protein delivers its warning message to cells when an infectious agent invades the body. The findings are important because this biological intruder alarm causes the body's immune system to leap into action to fight the infection. Learning more about how this process works, the researchers said, could lead to better treatments for diseases that occur when the immune system overreacts or pays too little attention to the infection alarm.

Collaborating with colleagues at the University of California, San Diego, the Johns Hopkins researchers have used their discoveries to develop a new computer model that could help produce medications for immune system-related ailments including septic shock, cancer, lupus and rheumatoid arthritis.

Their findings, which focused on how a large protein molecule called tumor necrosis factor, or TNF, triggers an immune response, were reported in the February issue of the Journal of Biological Chemistry.

"We were surprised by how sensitive cells were to small amounts and brief exposures to TNF," said Andre Levchenko, a Johns Hopkins assistant professor of biomedical engineering and senior author of the paper. "Our analysis may help drug companies solve problems with the regulation of immune response levels, and do it in a smart way."

In particular, Levchenko's team looked at the innate immune response, a localized reaction which normally stops an infection threat confined to a small part of the body, such as in the case of a pricked finger. (This is in contrast to a systemic response that triggers an immune reaction throughout the body, causing a fever. If the immune system responds too aggressively in such cases, the result may be a dangerous condition called septic shock.)

The innate immune response begins when white blood cells detect a bacterial intruder or toxin in the body. They produce TNF to car
'"/>

Source:Johns Hopkins University


Page: 1 2 3

Related biology news :

1. HIV Infection Still On The Rise
2. Fibril Shape Is The Basis Of Prion Strains And Cross-species Prion Infection
3. Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show Its Snot
4. Methamphetamine Abuse, HIV Infection Cause Changes in Brain Structure
5. Infections could contribute to adult brain tumours
6. Infection detectives use disease fingerprints to track common infections in children
7. Genome-wide mouse study yields link to human leukemia
8. Marine sponge yields nanoscale secrets
9. Small worm yields big clue on muscle receptor action
10. Organic farms produce same yields as conventional farms
11. GM crop that holds on to its seeds offers higher yields
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Infection alarm yields clues immune system behavior

(Date:3/24/2015)... , March 24, 2015   Crossmatch ... solutions, today announced that its U.are.U ® ... retailer Goorin Bros . to achieve PCI ... solution secures access to the POS terminal, protecting ... risk of data breaches. With ...
(Date:3/23/2015)... YORK , March 23, 2015   HOYOS ... property management company, today announced that the Company will ... for both enterprise and consumers at Connect:ID on March ... HOYOS Labs will highlight the IEEE Biometric ... TM ; and enterprise access control system. BOPS ...
(Date:3/23/2015)... OXFORD, Conn. , Mar. 23, 2015 NXT-ID, Inc. ... authentication company focused on the growing mobile commerce market, announces ... a new advertising campaign on CNBC television starting March 30 ... ads will commence airing in New York ... Executive Officer said: "We are excited about our new ad ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3
... New research in The FASEB Journal suggests that rats ... and increased appetite and muscle mass, as well as the number ... are looking to lean out, add muscle mass, and get ripped, ... ( http://www.fasebj.org ) suggests that you might want to look to ...
... Species, ability to overcome adversity goes beyond Darwin,s survival of ... a new study based on simulations examining species and their ... animal can make it to a final, climate-friendly destination isn,t ... way. It,s the extent to which the creatures can withstand ...
... endangered, but their long lives and broad distribution make ... level to different populations and devise appropriate conservation strategies. ... method to evaluate spatially and biologically distinct groups of ... identify threats and data gaps at different scales. ...
Cached Biology News:Lift weights, eat mustard, build muscles? 2Climate change will show which animals can take the heat 2Climate change will show which animals can take the heat 3
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Athena ... personal development of executive women in San Diego’s technology ... the 17th Annual Pinnacle Awards at their Gala on ... Hyatt Hotel. Register now at http://athenasd.org/events/ , ... support the Athena San Diego vision of fostering networking, ...
(Date:4/23/2015)... , April 23, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... report its first quarter 2015 results before the Nasdaq ... then host a live conference call and webcast to discuss ... morning, April 30, 2015 at 8:00 a.m. Eastern Time ... the live conference call by dialing 866-952-1906 (US) or ...
(Date:4/23/2015)... Prospects for Leading Companies in ... Details   We predict the global healthcare ... in 2015 and will grow at a CAGR of 6.3% ... around the world and increasing functional requirements for healthcare packaging ... global healthcare packaging market. A global ageing population, ...
(Date:4/23/2015)... April 23, 2015 /PRNewswire/ - Crystal Research Associates, LLC ... Overview ® (EIO) on Aeterna Zentaris Inc. (NASDAQ: ... available on Crystal Research Associates, website at ... website at www.aezsinc.com . Aeterna Zentaris ... biopharmaceutical company in oncology, endocrinology, and women,s health. With ...
Breaking Biology Technology:Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2Healthcare Packaging Market Forecast 2015-2025 2Healthcare Packaging Market Forecast 2015-2025 3Healthcare Packaging Market Forecast 2015-2025 4Healthcare Packaging Market Forecast 2015-2025 5Healthcare Packaging Market Forecast 2015-2025 6Healthcare Packaging Market Forecast 2015-2025 7Healthcare Packaging Market Forecast 2015-2025 8Healthcare Packaging Market Forecast 2015-2025 9Healthcare Packaging Market Forecast 2015-2025 10Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3
... Sept. 19 NPS,Pharmaceuticals, Inc. (Nasdaq: NPSP ... Administration,s Office of Orphan Products Development has granted,orphan ... for,injection) for the treatment of hypoparathyroidism, a rare ... FDA-approved therapy. Hypoparathyroidism afflicts approximately 65,000 people ...
... NeurogesX, Inc.,(Nasdaq: NGSX ), a biopharmaceutical company ... it is scheduled to present,at the 2007 UBS Global ... President and Chief Executive Officer, and Jeffery,Tobias, Chief Medical ... September 25, 2007 Time: 9:00 a.m. ...
... Sept. 19 The Pittsburgh Life Sciences,Greenhouse ... life,sciences industry on a fast track for ... in Coventina Healthcare Enterprises, Inc., a medical,device ... Frequency),and multi-modal treatment systems for research, rehabilitation, ...
Cached Biology Technology:PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism 2PREOS(R) Granted U.S. Orphan Drug Status for Treatment of Hypoparathyroidism 3NeurogesX to Present at UBS 2007 Global Life Sciences Conference 2NeurogesX to Present at UBS 2007 Global Life Sciences Conference 3The PLSG Invests $150,000 in Coventina Healthcare Enterprises, Inc., Its Eighth Company Relocation to Pittsburgh 2The PLSG Invests $150,000 in Coventina Healthcare Enterprises, Inc., Its Eighth Company Relocation to Pittsburgh 3
Agar, 500 g. Noble Agar.Moisture: < 10%, ash: < 1.6%, EEO (-mr): < 0.450 (pH 8.4). Category: Nucleotides & Enzymes & Biochemicals, Ultrapure Biochemicals ....
Ms anti-Cyclophilin D...
... Intended to qualitatively detect ... formalin-fixed, paraffin-embedded (FFPE) tissue ... and cell preparations, using ... (CISH). Fluorescent In Situ ...
Mouse GM CSF Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
Biology Products: