Navigation Links
Individual differences in a clock gene predict decline of performance during sleep deprivation

People are known to differ markedly in their response to sleep deprivation, but the biological underpinnings of these differences have remained difficult to identify. Researchers have now found that a genetic difference in a so-called clock gene, PERIOD3, makes some people particularly sensitive to the effects of sleep deprivation. The findings, reported by Antoine Viola, Derk-Jan Dijk, and colleagues at the University of Surrey's Sleep Research Center, appear online this week in the journal Current Biology, published by Cell Press.

There are two variants of the PERIOD3 gene found in the human population, encoding either long or short versions of the corresponding protein. Each individual will possess two copies of the gene, either of which might be the long or short form. Previous work had indicated that the different forms of the gene appear to influence characteristic morning and evening activity levels—for example, "owl" versus "lark" tendencies.

In the new work, a multidisciplinary research team consisting of biological scientists and psychologists compared how individuals possessing only the longer gene variant and those possessing only the shorter one coped with being kept awake for two days, including the intervening night. The researchers found that although some participants struggled to stay awake, others experienced no problems with the task.

The results were most pronounced during the early hours of the morning (between 4 and 8 a.m.), during which individuals with the longer variant of the gene performed very poorly on tests for attention and working memory.

The authors point out that this early-morning period corresponds to stretches of time when shift workers struggle to stay awake, during which many accidents related to sleepiness occur. But the scientists also emphasize that the new research was conducted in the laboratory, and whether forms of the PERIOD3 gene also predict individual differences in the tolerance
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimers, Parkinsons Disease
2. Team Invents Device For Weighing Individual Molecules
3. Individuals and populations differ in gene activity levels, not just genes
4. Variation in womens X chromosomes may explain differences among individuals, between sexes
5. Big differences in duplicated DNA distinguish chimp and human genomes
6. Identical twins may have more differences than meet the eye
7. Study outlines genetic differences between potential pandemic influenza strains
8. Brain differences could explain why males and females experience pain relief differently
9. Most human-chimp differences due to gene regulation ?not genes
10. Albatross study shows regional differences in ocean contamination
11. Viral genetic differences are possible key to HIV dementia
Post Your Comments:
(Date:7/25/2014)... the age girls reach puberty is influenced by ,imprinted genes,a ... contributes the gene. This is the first evidence that ... and details of this study were published today in the ... known as menarche, is a marker for the timing of ... of menses varies between girls, is an inherited trait, and ...
(Date:7/25/2014)... CORAL SPRINGS, Florida , July 25, 2014 /PRNewswire/ ... influential as more consumers are turning to digital technology ... NXT-ID, Inc. (OTCBB: NXTD), Google Inc. (NASDAQ: ... Visa Inc. (NYSE: V ), Apple Inc. ... FTNT) NXT-ID, Inc., (OTCQB: NXTD) a biometric ...
(Date:7/24/2014)... July 24, 2014 /PRNewswire-iReach/ -- The Geneva Healthcare Suite, ... devices, has cut emergency room wait times by an ... (UCSD) Medical Center, according to a recent study published ... Departments are using the suite to access data from ... defibrillators. "Using Geneva,s technology platform we have ...
Breaking Biology News(10 mins):Could age of first period influence development of diseases in older women? 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 2Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 3Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 4Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 5Consumer Needs for Identity Theft Security Grows with Popularity of Latest Smart Technology Products - Biometrically Secure Digital Wallet to Replace Credit Card Dependency 6UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 2UC San Diego Medical Center Cuts Average ER Wait Time by 92 Minutes using the Geneva Healthcare Suite 3
... its introduction fifty or so years ago, thermography has been ... in horses. The method is fast and safe and ... surface emits infrared radiation that can be detected by an ... The camera produces a coloured image that shows the ...
... received a $12 million grant from the National Institutes ... research on aphasia, a devastating language disorder that essentially ... U.S. alone, more than one million people suffer from ... will direct the new Center for the Neurobiology of ...
... dioxide in the Earth,s atmosphere created by the widespread burning ... climate change, and researchers the world over are looking for ... footprint. Now, researchers at the University of Georgia ... in the atmosphere into useful industrial products. Their discovery may ...
Cached Biology News:Blowing in the wind: How accurate is thermography of horses' legs? 2$12 million for a center for research on aphasia 2$12 million for a center for research on aphasia 3UGA discovery may allow scientists to make fuel from CO2 in the atmosphere 2
(Date:7/24/2014)... July 24, 2014 Gain recognition ... Supply Chain of the biotech industry. Nominations are ... Awards, brought to you by the Bio ... of supply chain management professionals for the past ... stakeholders of the Biotech industry – Manufacturers, Service ...
(Date:7/24/2014)... equipment, trained personnel, and detection dogs to safeguard ... A revolutionary new electronic chip with nano-sized chemical ... easier. , The groundbreaking nanotechnology-inspired sensor, devised by ... School of Chemistry and Center for Nanoscience and ... picks up the scent of explosives molecules better ...
(Date:7/24/2014)... prefer to settle into equilibriuma state of unchanging ... realm of non-equilibrium conditions where new possibilities lie. ... phases, such as temperature fluctuations, freezing and melting, ... their body temperature, airplanes to fly, and the ... But even though these conditions exist naturally and ...
(Date:7/24/2014)... , July 24, 2014 SRI International has ... the National Institute of Allergy and Infectious Diseases (NIAID), ... preclinical development of potential therapies for HIV infection and ... treat HIV and AIDS and the complications and opportunistic ... for preventing sexual transmission of HIV. ...
Breaking Biology Technology:Call for Submission: BSMA’s Supply Chain Management Innovation Awards 2Call for Submission: BSMA’s Supply Chain Management Innovation Awards 3Nano-sized chip 'sniffs out' explosives far better than trained dogs 2New approach to form non-equilibrium structures 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3
... EMERYVILLE, Calif., Aug. 3 NovaBay Pharmaceuticals, Inc. ... J. Wu has joined the company as senior vice ... than 30 years of highly successful experience in the ... business development, licensing, international marketing, project management, clinical development, ...
... , BOTHELL, WA and VANCOUVER, Aug. 3 /PRNewswire-FirstCall/ - OncoGenex ... Company will announce second quarter financial results on Thursday, August ... webcast at 4:30 p.m. EDT that afternoon to discuss quarterly ... Relations page of the OncoGenex Web site at www.oncogenex.com ...
... COUNTY, Calif., Aug. 2 Beckman Coulter, Inc. (NYSE: ... products that simplify, automate and innovate complex biomedical testing, announced ... business. This acquisition, first announced in February, extends Beckman ... , (Logo: http://www.newscom.com/cgi-bin/prnh/20031202/BECLOGO ...
Cached Biology Technology:NovaBay(R) Pharmaceuticals Names Roy J. Wu as Senior Vice President for Business Development 2NovaBay(R) Pharmaceuticals Names Roy J. Wu as Senior Vice President for Business Development 3Beckman Coulter Completes Acquisition of Olympus' Lab-Based Diagnostics Business 2