Navigation Links
Increased sensitivity to nerve signals keeps diabetes at bay

Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood sugar control, according to a report in the June 7, 2006, Cell Metabolism. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said.

Mice in which the pancreas cells that produce insulin, or beta cells, lack so-called M3 muscarinic acetylcholine receptors develop some symptoms of diabetes, including impaired glucose tolerance and reduced insulin release, the authors report. M3 receptors are normally on the receiving end of messages relayed by involuntary nerves that indicate the presence of food.

In contrast, mice genetically altered to harbor an excess number of beta cell M3 receptors show the opposite: a profound increase in glucose tolerance and insulin release, the researchers found. Moreover, such animals become resistant to developing symptoms of diabetes or prediabetes when fed a high-fat diet.

The findings suggest that drugs that boost the activity of the M3 receptors on pancreatic beta cells might have therapeutic potential, said Jurgen Wess of the National Institute of Diabetes and Digestive and Kidney Diseases.

"There may be ways to specifically drive up the number of M3 receptors expressed in pancreatic beta cells," Wess said. "It might also be possible to enhance M3 receptor signaling in beta cells by targeting proteins that modulate M3 receptor function in a specific fashion."

Receptors of the same type are also found in other parts of the body, he explained. Therefore, drugs that directly stimulate M3 receptors in general would likely come with problematic side effects--for example, causing smooth muscles to contract.

One of three branches of the involuntary nervous system, the parasympathetic, or "rest and digest" system fulfills many roles--slowing the heart rate, dilating blood vessels, and stimulating digestive secretions.< /p>

Food intake is known to trigger an increase in parasympathetic nerve impulses involving signals of different origins that are integrated in the brain, the researchers said. In the pancreas, parasympathetic nerve endings release the messenger acetylcholine before and most likely after food is absorbed.

"However, the importance of parasympathetic innervation of pancreatic beta cells in maintaining normal glucose balance had remained controversial," Wess said. "Much of this controversy has arisen because peripheral parasympathetic nerves release at least five different neurotransmitters, and increased parasympathetic outflow affects the function of many organs and tissues that have important metabolic functions."

The researchers overcame those difficulties in the current study by examining the glucose tolerance and insulin release of otherwise normal mice that were deficient for M3 receptors only in pancreatic beta cells, and in mice that contained an increased number of M3 receptors specifically in beta cells.

"We've established an important role for the native M3 receptor in beta cells in maintaining normal insulin release and blood glucose levels," Wess said. "It's also clear from our findings that the parasympathetic nervous system's modulation of blood sugar is not a transient event--its effects on the pancreas are sustained for a long time after a meal."


'"/>

Source:Cell Press


Related biology news :

1. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
2. Increased risk of osteoporosis associated with gene that one in five people have
3. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
4. Childrens taste sensitivity and food choices influenced by taste gene
5. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
6. Assessing the Amazon Rivers sensitivity to deforestation
7. Global warming increases oyster sensitivity to pollution
8. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
9. Clock molecules sensitivity to lithium sheds light on bipolar disorder
10. With record resolution and sensitivity, tool images how life organizes in a cell membrane
11. Restoring tamoxifen sensitivity in resistant breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
(Date:4/15/2016)... , April 15, 2016 ... the,  "Global Gait Biometrics Market 2016-2020,"  report to ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ,The global gait biometrics ... of 13.98% during the period 2016-2020. ... angles, which can be used to compute factors ...
(Date:3/31/2016)...  Genomics firm Nabsys has completed a financial  restructuring ... , M.D., who returned to the company in October ... team, including Chief Technology Officer, John Oliver , ... and Vice President of Software and Informatics, Michael ... Dr. Bready served as CEO of Nabsys from 2005-2014 ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... 23, 2016  The Biodesign Challenge (BDC), a university ... to harness living systems and biotechnology, announced its winning ... New York City . ... showcased projects at MoMA,s Celeste Bartos Theater during the ... MoMA,s senior curator of architecture and design, and ...
Breaking Biology Technology: