Navigation Links
Increased sensitivity to nerve signals keeps diabetes at bay

Nerve signals relayed directly to the pancreas after eating a meal play a critical role in normal blood sugar control, according to a report in the June 7, 2006, Cell Metabolism. Therefore, drugs that increase the sensitivity to such signals might offer a new approach to diabetes treatment, the researchers said.

Mice in which the pancreas cells that produce insulin, or beta cells, lack so-called M3 muscarinic acetylcholine receptors develop some symptoms of diabetes, including impaired glucose tolerance and reduced insulin release, the authors report. M3 receptors are normally on the receiving end of messages relayed by involuntary nerves that indicate the presence of food.

In contrast, mice genetically altered to harbor an excess number of beta cell M3 receptors show the opposite: a profound increase in glucose tolerance and insulin release, the researchers found. Moreover, such animals become resistant to developing symptoms of diabetes or prediabetes when fed a high-fat diet.

The findings suggest that drugs that boost the activity of the M3 receptors on pancreatic beta cells might have therapeutic potential, said Jurgen Wess of the National Institute of Diabetes and Digestive and Kidney Diseases.

"There may be ways to specifically drive up the number of M3 receptors expressed in pancreatic beta cells," Wess said. "It might also be possible to enhance M3 receptor signaling in beta cells by targeting proteins that modulate M3 receptor function in a specific fashion."

Receptors of the same type are also found in other parts of the body, he explained. Therefore, drugs that directly stimulate M3 receptors in general would likely come with problematic side effects--for example, causing smooth muscles to contract.

One of three branches of the involuntary nervous system, the parasympathetic, or "rest and digest" system fulfills many roles--slowing the heart rate, dilating blood vessels, and stimulating digestive secretions.<
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
2. Increased risk of osteoporosis associated with gene that one in five people have
3. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
4. Childrens taste sensitivity and food choices influenced by taste gene
5. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
6. Assessing the Amazon Rivers sensitivity to deforestation
7. Global warming increases oyster sensitivity to pollution
8. Mutations in the BRAF gene predict sensitivity to a novel class of cancer drugs
9. Clock molecules sensitivity to lithium sheds light on bipolar disorder
10. With record resolution and sensitivity, tool images how life organizes in a cell membrane
11. Restoring tamoxifen sensitivity in resistant breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Increased sensitivity nerve signals keeps diabetes bay

(Date:4/23/2014)... allergies and other chronic inflammatory disorders among people of ... their reduced exposure to the microbes that thrive in ... The article, published in the journal Clinical & ... centers who have less access to green spaces may ... caused by immune system dysfunction. , When our immune ...
(Date:4/23/2014)... This news release is available in French and ... woman? Male or female? In humans and other mammals, the difference ... Y chromosome. It is present only in males, where the two ... chromosomes. Thus, the Y is ultimately responsible for all the morphological ... not always been the case. A very long time ago, the ...
(Date:4/23/2014)... ripping open a dinner roll, a fuel cell catalyst ... hydrogen molecule. Now researchers have captured a view of ... its hydrogen feast. The view confirms previous hypotheses and ... better for alternative energy uses. , This study is ... hydrogen halves end up in the structure of a ...
Breaking Biology News(10 mins):Rural microbes could boost city dwellers' health 2Rural microbes could boost city dwellers' health 3Male or female? 2Male or female? 3Halving hydrogen 2Halving hydrogen 3Halving hydrogen 4
... in Europe and United States are markedly underestimating the ... to prevent dangerous climate change because they work in ... from The University of Manchester, discovered that the lack ... has resulted in significant differences over who is responsible ...
... An international research team has identified a common gene ... atrial fibrillation. In their report in the journal ... that variations affecting a protein that may help control the ... is called lone atrial fibrillation (AF), a type seen in ...
... Blacksburg, Va. -- Math-based computer models are a powerful ... John Tyson, professor of biology at Virginia Tech, is ... and make decisions. "Cells receive information in the ... or radiation damage, for instance," Tyson said. "On the ...
Cached Biology News:Governments 'misjudging' scale of CO2 emissions 2Common gene variant may increase risk for a type of cardiac arrhythmia 2Biologists use mathematics to advance our understanding of health and disease 2Biologists use mathematics to advance our understanding of health and disease 3
(Date:1/14/2014)... January 14, 2014 EquitiesIQ, a leading ... (OTCQB: ALQA). Alliqua is an emerging biomedical company acquiring, ... wound care market. , Free report download: http://equitiesiq.com/reports/alliqua/ ... a seasoned management team and Board, which launched the ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility ... of Product Strategy. In this role, Michelle will work with ... guide in the development of iLab products. Her main goal ... benefit to the scientific community by offering the most advanced, ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Global ... developing innovative information technology solutions for patients, physicians, ... care stakeholders, announced today the signing of a ... Food and Drug Administration (FDA). This initiative ...
(Date:1/14/2014)... January 14, 2014 Kerr Corporation, a leading ... and additional how-to information about dual arch impressions on its ... Dual Arch Impressions,” the blog entry serves up a list ... houses a step-by-step demonstration by Dr. David Little as he ...
Breaking Biology Technology:EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... equity stake in Zenotech Laboratories to 45%, GURGAON, ... Laboratories Limited (Zenotech) today announced the,signing of Definitive Agreements, ... its current 7% to 45% at a price of ... involves: (a) Purchase of shares from the existing ...
... Monday, October 8, at 2:15 ... p.m. ... Sciences Holdings, Inc. (Nasdaq: ADLS ), a biopharmaceutical,company engaged in the ... respiratory diseases and,cancer, is scheduled to present at the Natixis Bleichroeder Hidden ...
... 3 /PRNewswire-FirstCall/ - Biomira Inc. (Nasdaq: BIOM ... President and Chief,Executive Officer, is scheduled to present ... 2:45pm PDT/5:45pm EDT on Wednesday, October 10. ... and can be accessed at: http://www.corporate-ir.net/ireye/confLobby.zhtml?ticker=BIOM&item_id=1 ...
Cached Biology Technology:Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3Advanced Life Sciences to Present at Natixis Bleichroeder Hidden Gems Conference 2
Rabbit polyclonal to Tryptophanyl tRNA synthetase ( Abpromise for all tested applications). Antigen: Recombinant full length protein (Human): Tryptophanyl tRNA synthetase Entrez Gene ID: 745...
Goat polyclonal to FBXO2 ( Abpromise for all tested applications). entrezGeneID: 26232 SwissProtID: Q9UK22...
Rat monoclonal to UGGT ( Abpromise for all tested applications)....
... (Ser843) Immunogen: ... encompassing the human, mouse, and rat ... Number: NM_153831 ... by immunoblot. ...
Biology Products: