Navigation Links
Increased risk of osteoporosis associated with gene that one in five people have

About nineteen percent of people have a genetic variation that may increase susceptibility to osteoporosis, a new study reveals. Researchers at Washington University School of Medicine in St. Louis demonstrated that in women the variant gene speeds up the breakdown of estrogen and is associated with low density in the bones of the hip.

The study will be reported in the February issue of the Journal of Bone and Mineral Research and is available online.


The gene, named CYP1A1, makes an abundant enzyme that detoxifies foreign substances and also breaks down estrogen as a normal part of maintaining proper estrogen balance. Within the general population, several variations of the CYP1A1 gene exist, and the variants differ from one another by one or more DNA base pairs.

"Previous studies showed that some CYP1A1 variants are linked to estrogen-related cancers, such as breast, ovarian or endometrial cancers," says Reina Armamento-Villareal, M.D., assistant professor of medicine in the Division of Bone and Mineral Diseases. "The link to estrogen suggested that the gene could also affect bone density. No one had ever investigated that possibility, so we set up a study to evaluate the relation between bone density and variations of the CYP1A1 gene."

The researchers studied 156 women with an average age of 63.5 years who were at least one year past menopause. They analyzed the genetic sequence of each woman's CYP1A1 gene to identify which of the genetic variants they possessed.

One of the variations of the gene, known to be present in 19 percent of the general population, was found in women who had significantly lower blood estrogen levels and higher levels of urinary estrogen breakdown products than normal. These women also had a higher than normal urinary concentration of a marker that indicates bone resorption and had significantly lower than normal bone density in regions of the upper femur near the hip joint.

"The data
'"/>

Source:Washington University School of Medecine


Page: 1 2

Related biology news :

1. Deficient DNA Repair Capacity Associated With Increased Risk Of Breast Cancer
2. WHO Warns Of Increased Risk Of Vector-borne Diseases In Tsunami-affected Areas
3. Increased sensitivity to nerve signals keeps diabetes at bay
4. New study reveals promising osteoporosis treatment
5. New weapon in battle against osteoporosis
6. Scientists identify a candidate gene for osteoporosis
7. Using dental X-rays to detect osteoporosis
8. NIH researchers discover protein that appears to regulate bone mass loss, the cause of osteoporosis
9. Signs of aging: Scientists evaluate genes associated with longevity
10. Radio-tracking associated with dramatic shift in water vole sex ratio
11. B cells are required for development of epithelial cancer associated with chronic inflammation
Post Your Comments:
(Date:9/30/2014)... trouble getting pregnanteven with IVF? Here,s some hope: A ... The FASEB Journal , explains how ... known as PAWP, which induced embryo development in human ... embryo development by the sperm cell during fertilization. , ... a major paradigm shift in our understanding of human ...
(Date:9/30/2014)... a suite of perilous threats in today,s ocean. ... climate change, fragile coral ecosystems are disappearing at ... some species of corals surrounding the island of ... in their tropical environment: coral guard-crabs. New research ... Marine Station scientist Seabird McKeon and the museum,s ...
(Date:9/29/2014)... gut bacteria called Clostridium ramosum , coupled with a ... is published this week in mBio , the online ... A research team from the German Institute of Human Nutrition ... including C. ramosum gained weight when fed a ... were less obese even when consuming a high-fat diet, ...
Breaking Biology News(10 mins):Synthetic sperm protein raises the chance for successful in vitro fertilization 2Smithsonian scientists discover coral's best defender against an army of sea stars 2Gut bacteria promote obesity in mice 2
... have learned to glide through the forest, from flying ... as it sounds ?snakes. , Now, add ants to ... Berkeley, and the University of Texas Medical Branch in ... known to actively direct their fall ?were first observed ...
... analysis published in the Feb. 8 PNAS supports the ... , Researchers in California, Israel, and Germany have compared ... the fruit fly ?and reported that protein "wiring" connections ... This first-of-its-kind analysis of three higher level organisms published ...
... building blocks of life--is exploding as scientists worldwide discover ... the development of organisms. The rapidly growing body of ... a shared vocabulary and system for describing, cataloging and ... scientists, known as the RNA Ontology Consortium, has now ...
Cached Biology News:Falling ants glide back to trunk to avoid dangers of forest floor 2Falling ants glide back to trunk to avoid dangers of forest floor 3Falling ants glide back to trunk to avoid dangers of forest floor 4Falling ants glide back to trunk to avoid dangers of forest floor 5Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits 2Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits 3Examination of internal 'wiring' of yeast, worm, and fly reveals conserved circuits 4RNA project to create language for scientists worldwide 2RNA project to create language for scientists worldwide 3
(Date:9/30/2014)... , Sept. 30, 2014 Nematicide ... kill nematodes. Nematodes are microscopic parasitic roundworms, found ... and inside other plants and animals. Nematicides have ... or other properties promoting migration through the soil. ... than 1,000 plant-parasitic nematodes. With more than 10,000 ...
(Date:9/30/2014)... Proove Biosciences , the commercial and ... a new genetic test built upon research from their ... will provide physicians with an objective way to ... are stratified between individuals. With this new test, physicians ... a genetic predisposition that will affect their pain tolerance. ...
(Date:9/30/2014)... 30, 2014  RegeneRx Biopharmaceuticals, Inc. (OTC: RGRX) ... has received a Canadian Patent for Inhibition or ... patent includes claims using thymosin beta 4, various ... for these purposes.  The patent will expire in ... ( www.regenerx.com ) RegeneRx is ...
(Date:9/30/2014)... September 30, 2014 Fast, ... of chemistry in documents ChemAxon ... and consulting services for life science research, launches ... generate Markush structures from documents. Markush ... property, however generating and understanding Markush structures is ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3RegeneRx Receives Canadian Patent for Inhibition or Reversal of Skin Aging 2ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2
... transplanting them may hold the key to optimizing stem ... Research published in BioMed Central,s open access Journal ... for victims of paralysis to recover the use of ... syndromes. , Dr. Stephen Davies, Associate Professor of Neurosurgery ...
... 19 Boston Scientific,Corporation (NYSE: BSX ) is ... which is being held September 22 - 25 in ... Officer, will make a,30-minute presentation which will be followed ... 25, beginning at approximately 9:00,a.m. ET., A live ...
... Inc. (OTC Bulletin Board: CHBT) (,China-Biotics," "the,Company"), ... manufacture,research, development, marketing and distribution of probiotics ... General Meeting of Shareholders,(the ,AGM,), stockholders re-elected ... of Directors., At the meeting, held ...
Cached Biology Technology:Breakthrough in spinal injury treatment 2China-Biotics, Inc. Announces Results of 2008 Annual General Meeting of Shareholders 2
Goat Anti-Horse IgG(T) Antibody, Unconjugated...
Goat polyclonal to STMN2 ( Abpromise for all tested applications). Antigen: Synthetic peptide: AKTAMAYKEK, corresponding to C terminal amino acids 2-11 of STMN2. Entrez Gene ID: 11075 Swi...
Mouse monoclonal antibody to RNase L...
Anti (porcine) Vitronectin...
Biology Products: