Navigation Links
Important discovery about second most fatal cancer

An international team of medical scientists has made an important advance in our understanding of the second most fatal form of cancer in the industrialized world. Professor Jeremy R. Jass, who holds a Canada Research Chair in Gastrointestinal Pathology at McGill University in Montreal, and colleagues in Australia and Japan have shown that in some cases colorectal cancer can be inherited. The new syndrome is characterized by distinctive clinical, pathological and molecular features:

# Early age at onset
# More common in females
# More common in right side of colon
# Little evidence of tumour immunity
# Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroid, ovary, and melanoma)
# Frequent DNA methylation (chemical change which inactivates many genes)
# Frequent but variable levels of DNA instability across different colorectal cancers occurring in members of same family
# Origin in serrated polyps (considered previously to be completely benign)

Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in the industrialized world. It has become clear in recent years that colorectal cancer is not a single disease but a group of diseases, each with a different cause and behaviour. The genetic basis of this new syndrome is not known but it is speculated that affected families have a genetic predisposition to develop DNA methylation. There is already evidence that subjects with colorectal cancer showing DNA methylation are more likely to have a family history of colon cancer and other types of cancer. Moreover, the colorectal cancers appear to develop in polyps that have been considered to be entirely harmless and have therefore been ignored up to now. These polyps also show mutation of the oncogene BRAF and DNA methylation. It is likely that the same polyps may sometimes become malignant in patients who are not members of high-risk families.

Alt hough familial - or inherited - forms of cancer are uncommon, they are of major importance for three reasons, says Dr. Jass:

1. Such cancers often occur in young subjects and result in loss of many years of life. An appreciation of the problem can lead to cancer prevention by a combination of prevention or detection of early cancer.

2. High-risk families provide an opportunity for investigating novel approaches of cancer prevention by the use of diet or chemical compounds. The results may be generalizable to the average-risk population.

3. An understanding of the genetic defect may provide important insight into the basic cause of the common non-inherited forms of the same type of cancer.

The findings of Dr. Jass and his colleagues are reported in the March 2005 edition of Clinical Gastroenterology and Hepatology, published by the American Gastroenterological Association.


'"/>

Source:McGill University


Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. New SARS Protein Linked To Important Cell Doorway
3. Important gene controlling tree growth and development found
4. Protein discovery could unlock the secret to better TB treatment
5. Purdue proves concept of using nano-materials for drug discovery
6. UCSD discovery may help extend life of natural pesticide
7. Leprosy microbes lead scientists to immune discovery
8. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
9. Researchers make surprise discovery that some neurons can transmit three signals at once
10. Harmless virus may hold key to more effective HIV drug discovery
11. Fundamental discovery -- Bone fracture
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... and BANGALORE, India , April 28, 2016 ... a product subsidiary of Infosys (NYSE: INFY ), ... a global partnership that will provide end customers ... mobile banking and payment services.      (Logo: ... innovation area for financial services, but it also plays a ...
(Date:4/19/2016)... , UAE, April 20, 2016 ... implemented as a compact web-based "all-in-one" system solution for ... biometric fingerprint reader or the door interface with integration ... modern access control systems. The minimal dimensions of the ... readers into the building installations offer considerable freedom of ...
(Date:4/13/2016)... 13, 2016  IMPOWER physicians supporting Medicaid patients in ... new clinical standard in telehealth thanks to a new ... higi platform, IMPOWER patients can routinely track key health ... mass index, and, when they opt in, share them ... to a local retail location at no cost. By ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , ... June 27, 2016 , ... ... bring innovative medical technologies, services and solutions to the healthcare market. The company's ... of various distribution, manufacturing, sales and marketing strategies that are necessary to help ...
(Date:6/24/2016)... discussions on a range of subjects including policies, debt and ... Poloz. Speaking at a lecture to the Canadian ... to the country,s inflation target, which is set by both ... "In certain areas there needs to be ... why not sit down and address strategy together?" ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... SPRING, Md. , June 23, 2016 A ... collected from the crime scene to track the criminal down. ... and the U.S. Food and Drug Administration (FDA) uses DNA ... Sound far-fetched? It,s not. The ... genome sequencing to support investigations of foodborne illnesses. Put as ...
Breaking Biology Technology: