Navigation Links
Important discovery about second most fatal cancer

An international team of medical scientists has made an important advance in our understanding of the second most fatal form of cancer in the industrialized world. Professor Jeremy R. Jass, who holds a Canada Research Chair in Gastrointestinal Pathology at McGill University in Montreal, and colleagues in Australia and Japan have shown that in some cases colorectal cancer can be inherited. The new syndrome is characterized by distinctive clinical, pathological and molecular features:

# Early age at onset
# More common in females
# More common in right side of colon
# Little evidence of tumour immunity
# Frequent mutation of an oncogene called BRAF (also mutated in cancer of thyroid, ovary, and melanoma)
# Frequent DNA methylation (chemical change which inactivates many genes)
# Frequent but variable levels of DNA instability across different colorectal cancers occurring in members of same family
# Origin in serrated polyps (considered previously to be completely benign)

Colorectal cancer is the second most frequent cause of death due to cancer (after lung cancer) in the industrialized world. It has become clear in recent years that colorectal cancer is not a single disease but a group of diseases, each with a different cause and behaviour. The genetic basis of this new syndrome is not known but it is speculated that affected families have a genetic predisposition to develop DNA methylation. There is already evidence that subjects with colorectal cancer showing DNA methylation are more likely to have a family history of colon cancer and other types of cancer. Moreover, the colorectal cancers appear to develop in polyps that have been considered to be entirely harmless and have therefore been ignored up to now. These polyps also show mutation of the oncogene BRAF and DNA methylation. It is likely that the same polyps may sometimes become malignant in patients who are not members of high-risk families.

Alt
'"/>

Source:McGill University


Page: 1 2

Related biology news :

1. Genes In The Interferon System Important In Systemic Lupus Erythematosus
2. New SARS Protein Linked To Important Cell Doorway
3. Important gene controlling tree growth and development found
4. Protein discovery could unlock the secret to better TB treatment
5. Purdue proves concept of using nano-materials for drug discovery
6. UCSD discovery may help extend life of natural pesticide
7. Leprosy microbes lead scientists to immune discovery
8. Biochemists report discovery of structure of major piece of telomerase; implications for cancer
9. Researchers make surprise discovery that some neurons can transmit three signals at once
10. Harmless virus may hold key to more effective HIV drug discovery
11. Fundamental discovery -- Bone fracture
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Important discovery about second most fatal cancer

(Date:7/28/2014)... Amundsen became the first man to reach the South ... later, an international team of scientists led by Joe ... that air pollution from industrial activities arrived long before. ... widely spaced locations around the Antarctic continent, including the ... precise reconstruction to date of lead pollution over the ...
(Date:7/27/2014)... species of mayfly in the southern Western Ghats, a mountain ... is the first time that any mayfly belonging to the ... , The new species, called Labiobaetis soldani , "is ... contribution to the understanding of the Ephemeroptera of Palaearctic and ... describes the new mayfly in the Journal of Insect ...
(Date:7/27/2014)... data," a single computer cannot always find the solution ... across a cluster of computers that analyze a massive ... your web history to present you with targeted ads, ... book or movie. But big data is about more ... brain activity are generating unprecedented quantities of information. That ...
Breaking Biology News(10 mins):Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 2Industrial lead pollution beat explorers to the South Pole by 22 years and persists today 3New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5
... Physics (IOP) today, Tuesday 29 June 2010, announces this ... international medal, going to theoretical physicist Professor Edward Witten ... of the most influential physicists of the past 30 ... the phenomenology of particle physics and cosmology to theoretical ...
... ham radio, amateur astronomy, and early computing? Well, ... 2,000 people from around the world belong to the ... fuel cells, low-cost lab equipment, environmental surveillance, personal bio-monitoring, ... Project at the Woodrow Wilson Center is partnering with ...
... Institute for Biologically Inspired Engineering at Harvard and ... produce simple sugars and lactic acid. This innovation ... producing commodity chemicals in bulk. Their research findings ... and Environmental Microbiology . This photosynthetic factory ...
Cached Biology News:IOP announces 2010 award winners 2Harvard's Wyss Institute develops technology to produce sugar from photosynthetic bacteria 2
(Date:7/28/2014)... 28, 2014 Research and Markets has ... Market 2014-2018" report to their offering. ... is a technique used to determine the size of a ... is crucial to analyze the size of particles as it ... analysis is performed to determine the behavior and nature of ...
(Date:7/26/2014)... NY (PRWEB) July 26, 2014 ... provides key market data on the Canada Endoscopy ... millions of US dollars, volume (in units) and ... - High-End Endoscopy Visualization Systems, Mid-Range Endoscopy Visualization ... Full Report at http://www.marketresearchreports.biz/analysis/213254 . , The ...
(Date:7/25/2014)... Calif. , July 25, 2014 Amgen ... of Directors today declared a $0.61 per share dividend ... be paid on Sept. 5, 2014, to all stockholders ... Aug. 14, 2014.  About Amgen Amgen ... patients suffering from serious illnesses by discovering, developing, manufacturing ...
(Date:7/25/2014)... University of Leicester has furthered our understanding of ... create new materials using nanosized ,building blocks,. , ... prestigious academic journal Physical Review Letters , ... rich detail the structure and internal atomic motion ... and a single helium atom. , The technique ...
Breaking Biology Technology:Global Particle Size Analysis Market 2014-2018 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 2Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster 3
... , , ... , , , ... highly sensitive,and specific method for the detection and quantitation,of mRNA species. ... RNA polymerases (SP6, T7,and T3). These enzymes possess several properties that,make ...
... , , ... , , , ... coli. The,enzyme has RNA-directed DNA polymerase activity,DNA-dependent DNA polymerase activity, unwinding,activity, and, ... , , , ...
... , , ... , , , Now ... sum of all,proteins encoded by a,genome at a specific stage.,Assembling the ... The reason for this is the complexity of protein,structure and function, ...
Cached Biology Technology:RNase Protection Assay (RPA),Using DIG-Labeled RNA Probes 2Increase the Power and Sensitivity for Your cDNA,Synthesis with the New Transcriptor Reverse Transcriptase 2Increase the Power and Sensitivity for Your cDNA,Synthesis with the New Transcriptor Reverse Transcriptase 3Increase the Power and Sensitivity for Your cDNA,Synthesis with the New Transcriptor Reverse Transcriptase 4Tools for Proteomic Science II 2Tools for Proteomic Science II 3Tools for Proteomic Science II 4
Recombinant Equine IL-6...
... two highly efficient methods of identifying recombinant ... By using the large-scale screen method in ... is to transfer partial colonies of E. ... into the solutions provided by the kits ...
... and G. Butcher (1998). • The major ... research in the immunology area. There is ... proteins and in their function as antigen-presenting ... with the prospect of tackling biochemical and ...
actin from rabbit muscle Cell Biology Cytoskeletal Probes Actin and Actin Probes...
Biology Products: