Navigation Links
Implanting dopamine generators in brain cells obtains improvement in Parkinson's in monkeys

d from the carotid body have been used as a source for dopaminergic cells in the treatment of Parkinson's disease in animal experiments and in humans. The advantage of this cell type with respect to others is the possibility of carrying out autoimplants, thus avoiding tissue rejection or immunosupressor treatment.

Research

Research was undertaken with monkeys who had Parkinson's induced by the administration of a neurotoxin (MPTP) and which were subsequently injected into the striate area of the brain with fragments from the carotid body of the same animal This region of the brain where the fragments from the carotid body are implanted is the area where dopamine from the dopaminergic neurones is released from the black substance. As is known, Parkinson's disease is produced as a result of the loss of 50% of the cells of the black substance (the brain stem structure) that manufactures dopamine and sends out projections to the striate area.

In order to implant dopaminergic cells in the brain, it is necessary to effect a trepanation through which the fragments from the carotid are injected into the striate area of the animal's brain. This work shows that the number of striate dopaminergic neurones that the striate area of the brain usually contains undergoes an additional increase after the implantation of these cell aggregates. Moreover, this increase in the number of dopaminergic cells appears to be responsible for the improvement of the illness in animals studied by the Navarra University Hospital and CIMA researchers, given that, this was not observed in those individuals receiving injections of saline serum instead of the cellular aggregates.

The fact that the injection into the striate area of neurotrophic factors (those that favour cell growth), such as GDNF, also causes a significant increase in dopaminergic neurones in this region of the brain indicates that the beneficial effect produced by the implant of cellula
'"/>

Source:Elhuyar Fundazioa


Page: 1 2 3

Related biology news :

1. Flies on speed offer insight into the roles of dopamine in sleep and arousal
2. Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
3. High dopamine transporter levels not correlated with ADHD
4. New dopamine brain target discovered
5. Controversial drug shown to act on brain protein to cut alcohol use
6. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
7. Mouse brain tumors mimic those in human genetic disorder
8. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
9. First atlas of key brain genes could speed research on cancer, neurological diseases
10. NYU study reveals how brains immune system fights viral encephalitis
11. Stem cells from brain transformed to produce insulin at Stanford
Post Your Comments:
(Date:7/30/2015)... VIEW, Calif. , July 30, 2015 /PRNewswire/ ... and services for gene function analysis and biomarker ... Guide RNA (sgRNA) Knockout Library targeting all human ... specifically and permanently "knock out" a gene,s function. ... provides a high throughput screening tool so that ...
(Date:7/21/2015)... 21, 2015 Today, ZTE announced its Android ... well as expected revenues in 2015 that relate to sales of ... guidance of approximately 2,200 MSEK for 2015. Jörgen Lantto, ... smartphone manufacturer in China and we are ... 5 for Axon , its ...
(Date:7/13/2015)... 13, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... company focused on the growing mobile commerce market, ... 62/188684 for BEHAVIORAL-DIRECTED AUTHENTIATION METHOD AND ... and secure method to make payments.  With this ... introduced with its groundbreaking voice-direct payment patent application, ...
Breaking Biology News(10 mins):CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2NXT-ID Patents Behavior-Directed Payments 2NXT-ID Patents Behavior-Directed Payments 3NXT-ID Patents Behavior-Directed Payments 4
... adult male sea turtles ( Caretta caretta ) using ... the potential risks posed to this threatened species by ... Toxicology and Chemistry , examines the different levels of ... turtles. "The risks posed by persistent organic pollutants ...
... BUFFALO, NY -- Exposure to air pollution early in life ... may alter her DNA and may be associated with premenopausal ... Buffalo have shown. The findings indicated that higher air ... increase levels of E-cadherin, a protein important to the adhesion ...
... in German . , Is the vacuum-packed ... not tell the whole story. And the "best-before" date is ... have added to the uncertainty, and the customer him- or ... This is an area in which a sensor film developed ...
Cached Biology News:Satellite tracking of sea turtles reveals potential threat posed by manmade chemicals 2Air pollution exposure affects chances of developing premenopausal breast cancer 2Rotten meat doesn't stand a chance 2
(Date:7/30/2015)... , July 30, 2015 AACC ... to the 2015 AACC Annual Meeting & Clinical ... from July 26–30. The meeting showcased revolutionary advancements ... the ability of healthcare providers to diagnose patients ... effective medical treatment. As of ...
(Date:7/30/2015)... ... July 30, 2015 , ... Leading regenerative ... study of its canine osteoarthritis stem cell product, currently under development for FDA ... and will be marketed in the US by Aratana. This product, termed AT-016, ...
(Date:7/30/2015)... -- HIGHLIGHTS:Q2 2015 Results (all changes are ... sales were $697 million compared to $701 million in ... 8%, and changes in foreign currency exchange rates decreased ... , By business unit, organic sales growth was ... SAFC Commercial. , Reported diluted EPS was $0.98 ...
(Date:7/29/2015)... PARIS , July 30, 2015 ... de la santé, publie ses résultats pour le ... Brandicourt commente les résultats. Visionner ... http://www.eurobusinessmedia.com/ceo-direct/sanofi/sanofi-h1-2015-results-interview-with-ceo-olivier-brandicourt?utm_source=ceo-direct&utm_medium=wire Au sommaire ... - Moteurs de croissance ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 2VetStem Biopharma Successfully Completes Large Milestone Efficacy Study for its Flagship Canine Osteoarthritis Stem Cell Product 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 2Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 3Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 4Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 5Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 6Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 7Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 8Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 9Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 10Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 11Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 12Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 13Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 14Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 15Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 16Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 17Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 18Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 19Sigma-Aldrich (NASDAQ - SIAL) Reports Q2 2015 Sales Of $697 Million And Adjusted Diluted EPS Of $1.01 20
... as a "biotech hotspot," this time in e-mail newsletter ... state's profile and is just what the biotech industry ... list of five hotspots were California, Maryland, New Jersey ... the list, told Forbes it was a subjective ranking ...
... Innovation Center Back in the mid-1980s, encouraging economic ... public utilities. But then Plant Sites & Parks magazine ... U.S. , ,Jim Mohrbacher, who worked in corporate ... and mentioned to a colleague that he thought Madison ...
... Corporation is expanding into nearly 4,000 square feet of ... few minutes south of Madison. , ,Symphony CEO Ravi Kalla ... to be customized to make it possible to serve clients ... and video conferencing capabilities to allow contact with a hundred ...
Cached Biology Technology:Utilities help switch on economic development 2Utilities help switch on economic development 3Utilities help switch on economic development 4
...
...
... I-96 Plate can be used either in ... large-scale (i.e., 96-well) purification of DNA and/or ... unique silica-based matrix make it perfect for ... RNA in = 10 l eluate per ...
Request Info...
Biology Products: