Navigation Links
Immune system's distress signal tells bacteria when to strike back

barrier cells that line the host's bowel to become more permeable, which renders them more susceptible to the microbe's toxins. Pyocyanin enhances the germ's ability to pass through the weakened bowel wall, enter the bloodstream and invade tissue.

"Our goal," Alverdy said, "is to understand the many steps in this process and use that knowledge to find novel ways to intervene, to stop the infection before it starts rather than trying to kill all the germs."

Many harmful bacteria have already learned how to resist the drugs developed to treat them. Scientists are now looking at alternatives, such as ways to block or scramble the chemical messages that allow microbes to eavesdrop on their hosts or to conspire together to mount an attack.

"We chose to study this in Pseudomonas because it is one of the deadliest infections for patients who undergo major surgery," said Alverdy. "We suspect something very similar, however, occurs in all sorts of infections."

Inflammatory bowel disease patients, for example, have elevated cytokines ?the chemical messengers that trigger an immune response ?in the bowel. "These could signal the bug," said Alverdy, "then the bug strikes back and then the inflammation process snowballs." Because the bacteria in this case are "normal flora," people with no real infection develop a chronic disease.

The battles between pathogens and their hosts have been going on for millions of years, Alverdy said, with each side constantly devising novel measures, countermeasures, and counter-countermeasures, including sophisticated mutual espionage.

The discovery of antibiotics gave human hosts a temporary advantage, "but that seems to be waning a bit," he added. "We need to learn new ways to understand our germs and think about how to placate rather than annihilate them."


'"/>

Source:University of Chicago Medical Center


Page: 1 2 3

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. New Lab Research May Help Those Deafened By Immune System Attack
7. Key To Stem Cell Transplant Success Is Tricking Immune System
8. Immune system has evolved to prevent autoimmune disease
9. Defective Gene Linked to Two Inherited Immune Deficiencies
10. How Dirt Could Educate The Immune System And Help Treat Asthma
11. Immune response to HIV in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune system distress signal tells bacteria when strike back

(Date:7/9/2014)... amphibians with the highest distribution in the Iberian Peninsula. ... it comes into contact with the red swamp crayfish, ... the Spaniard Germn Orizaola from the University of Uppsala ... developed a defensive response to the invasive species. They ... co-exist with the crayfish. , Numerous invasive organisms are ...
(Date:7/9/2014)... are less fit in terms of cardiorespiratory capacity, ... Moreover, southern adolescents are more obese and present ... those from the centre-north of Europe. , These ... ambitious study conducted by scientists from the University ... with 25 other European research groups. The study ...
(Date:7/8/2014)... coral reefs and the animals that depend on them ... symbiotic sea creature to get fatand to be flexible ... In the first study of its kind, scientists at ... that live symbiotically with algaeare better able to recover ... they keep large energy reservesmostly as fatsocked away in ...
Breaking Biology News(10 mins):Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3Adolescents from southern Europe are less fit and more obese than central-northern European peers 2For corals adapting to climate change, it's survival of the fattest -- and most flexible 2For corals adapting to climate change, it's survival of the fattest -- and most flexible 3For corals adapting to climate change, it's survival of the fattest -- and most flexible 4
... time, researchers have restored significant bladder function through nerve regeneration ... The breakthrough paired a traditional nerve bridge graft with a ... grow new nerve cells from the thoracic level to the ... the June 26 issue of the Journal of Neuroscience ...
... 2013 Nausea is one of the most debilitating symptoms ... the United States. Leading headache physician, Dr. Zoltan Medgyessy of ... that pressure to the P6 antiemetic point on the inner ... therapy for relieving nausea of migraine sufferers. He will ...
... and vitamin D supplements after menopause for bone health? ... analysis from the major Women,s Health Initiative (WHI) trial ... taking hormones after menopause. The analysis was published online ... North American Menopause Society. Among the nearly 30,000 ...
Cached Biology News:Bladder function restored in animals with severe spinal cord injury 2Bladder function restored in animals with severe spinal cord injury 3Efficacy of acupressure to relieve migraine nausea presented at International Headache Congress 2Calcium and vitamin D help hormones help bones 2
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
(Date:1/14/2014)... 2014 iLab Solutions, the leader in core ... Director of Product Strategy. In this role, Michelle will work ... to guide in the development of iLab products. Her main ... possible benefit to the scientific community by offering the most ...
(Date:1/14/2014)... Cardiff, UK (PRWEB) January 13, 2014 ... leader with more than 20 years in the industry, ... and photonics . Hainsey will serve as the society’s ... have Dr. Hainsey join SPIE as our Technology Strategist, ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... chemistry-driven contract research organization, announced today that its ChemRar ... the leading CRO companies conducting high quality Phase I ... continue to operate separately under the business name ... acquisition ChemDiv had worked with Prudentas, who established itself ...
... Required to Meet Growing Demand , ... Arlington, Va. ... enough grain to meet the growing demand for food, biofuels and ... around the globe take a more holistic approach to the solution, ...
... StandardsWASHINGTON, April 16 URAC , ... today that Director of Pharmacy Programs Janice Anderson, RPh, ... 21st Annual Academy of Managed Care Pharmacy (AMCP) Meeting ... care professionals dedicated solely to the issues of managed ...
Cached Biology Technology:ChemDiv Group Acquires Prudentas Through ChemRar High Tech Center 2ChemDiv Group Acquires Prudentas Through ChemRar High Tech Center 3DuPont Leader: Agriculture is Up to Global Productivity Challenge 2DuPont Leader: Agriculture is Up to Global Productivity Challenge 3DuPont Leader: Agriculture is Up to Global Productivity Challenge 4URAC Director of Pharmacy Programs to Speak at Academy of Managed Care Pharmacy Annual Meeting 2URAC Director of Pharmacy Programs to Speak at Academy of Managed Care Pharmacy Annual Meeting 3
Eagle's Ham's amino acids; EHAA...
... IRsolution software provides quick and easy operation ... with Windows-based control. The software is ... FDA 21 CFR Part 11 regulations, and ... measurement. IRsolutions versatility enables use in ...
... introduce random mutations to the gene supplied by ... into a vector of choice to obtain a ... can be set to a desired value within ... 106-108. Mutations can be restricted to a ...
... EVOlyzer is Tecans new Enzyme-Linked Immunosorbent Assay ... Freedom EVOlyzer is a dedicated EVO platform ... reader, washer and incubation units operated by ... EVOlyzer is available in three sizes - ...
Biology Products: