Navigation Links
Immune system's distress signal tells bacteria when to strike back
The human opportunistic pathogen, Pseudomonas aeruginosa, has broken the immune system's code, report researchers from the University of Chicago, enabling the bacteria to recognize when its host is most vulnerable and to launch an attack before the weakened host can muster its defenses.
In the 29 July 2005 issue of Science, the researchers show how this lethal organism detects interferon-gamma, a chemical messenger the immune system uses to coordinate its efforts to get rid of bacteria. When these bacteria intercept this message, they recognize it as a threat, assess their own numbers and, if they have sufficient strength, activate genes that quickly transform them from benign passengers in the bowel into deadly blood-stream invaders.
"Most of the time these microbes are content to live and grow in our intestines," said John Alverdy, M.D., professor of surgery at the University of Chicago and director of the study. "They don't feel the need or even look for the opportunity to attack. But when they detect a threat, they have a remarkably sophisticated defense plan, based, unfortunately, on the notion that the best defense is an overwhelming offense."
Pseudomonas aeruginosa is ubiquitous. It lives in all sorts of moist places, including damp soil and on the surface of vegetables, as well as in streams, faucets and drinking fountains. It is often a long-term bowel tenant, colonizing the intestines of about three percent of healthy people.
In the bowel this germ is usually harmless, but it can turn deadly, causing gut-derived sepsis. It is also a frequent cause of infections after major surgery.
Physicians have theorized, said Alverdy, that germs such as Pseudomonas are always "probing for a weakness in the host and are ready and willing to strike whenever they find one." He and his colleagues, however, are testing an alternative theory: that "bacteria are perfectly content in their niche until signals from the host ?usually during
'"/>
Source:University of Chicago Medical Center
Related biology news :
1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. New Lab Research May Help Those Deafened By Immune System Attack
7. Key To Stem Cell Transplant Success Is Tricking Immune System
8. Immune system has evolved to prevent autoimmune disease
9. Defective Gene Linked to Two Inherited Immune Deficiencies
10. How Dirt Could Educate The Immune System And Help Treat Asthma
11. Immune response to HIV in the brain
Post Your Comments:
(Date:6/17/2013)... patients with severe brain infections in Vietnam. Further research ... for the symptoms of disease. , The virus was ... patients with severe brain infections in the study, corresponding ... 122 patients with non-infectious brain disorders that were tested. ... are often fatal and patients who do survive, often ...
(Date:6/17/2013)... foundations with more modern elements. Using this same approachbut ... Dietrich School of Arts and Sciences have designed a ... storage, and gas transport more efficient and at a ... issue of the Journal of the American Chemical ... builds upon Pitt Associate Professor of Chemistry Nathaniel Rosi,s ...
(Date:6/17/2013)... 2013) The AGA Research Foundation and Horizon Pharma ... of gastroenterology with the 2013 AGA-Horizon Pharma Fellow Abstract ... , "In its third year, this competition continues to ... on promising careers in basic and clinical research," said ... Research Foundation. "We are extremely proud of all that ...
Breaking Biology News(10 mins):New virus isolated from patients with severe brain infections 2New virus isolated from patients with severe brain infections 3'Chemical architects' build materials with potential applications in drug delivery and gas storage 2Horizon Pharma Abstract Prizes recognize promising fellows and students 2... from the University of Exeter has revealed taking a dietary ... boost stamina during high-intensity exercise. The study has important ... can allow people to exercise up to 20% longer and ... comes on the back of previous research from Exeter which ...
... such as depression, anxiety disorders, addiction and schizophrenia are ... the world. In the EU alone, each year 27% ... 83 Million citizens suffer from mental disorders. Depression ... as the most disabling disorder of all diseases. Unless ...
... Nev. There is still much that is unknown ... Reno psychologist has added to the body of knowledge ... to demystify, prevent and treat the mysterious condition. ... assistant professor of psychology at the University of Nevada, ...
Cached Biology News:Supplement produces a 'striking' endurance boost 223rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 223rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 323rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 423rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 523rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 623rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 723rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 823rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 923rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 1023rd ECNP Congress: Pioneering CNS research -- translating neuroscience into clinical progress 11University of Nevada professor studies structural basis for autism disorders 2(Date:6/14/2013)... 2013 Stem cells have long been touted as the ... to Dr. Dennis Lox , some patients with a ... to stem cell therapy for aid. Avascular necrosis (AVN) also ... in which the blood supply to the bone becomes disrupted, ... to as necrosis. The region may be very painful, and ...
(Date:6/14/2013)... DIEGO , June 14, 2013 Mast Therapeutics, ... an underwritten public offering of 50,000,000 units, each unit ... common stock and one warrant to purchase 0.5 of ... price of $0.50 per unit. The units will not ... stock and the warrants are immediately separable and will ...
(Date:6/14/2013)... Toronto, ON / Boston, MA (PRWEB) June 14, ... the world’s largest independent resource for life scientists ... new e-commerce features within the growing 1DegreeBio marketplace. ... quickly browse through hundreds of vendor catalogues, access ... create purchase orders, email products to lab managers ...
(Date:6/13/2013)... Eagle Biosciences is proud to announce ... Calprotectin ELISA assay kit that offers the ... µg/g stool). The Calprotectin ELISA assay kit is ... Calprotectin (neutrophil cytoplasmic protein s100A8/A9, MRP 8/14) in ... assay line which already includes Alpha 1 Antitrypsin ...
Breaking Biology Technology:Stem Cells May Help Some With Avascular Necrosis (AVN) 2Mast Therapeutics Prices Public Offering Of Units 2Mast Therapeutics Prices Public Offering Of Units 3Mast Therapeutics Prices Public Offering Of Units 41DegreeBio Inc. Boosts Review-Driven Reagent Marketplace with New e-Commerce Platform 2Eagle Biosciences Introduces Highly Sensitive Calprotectin ELISA Assay Kit 2... hardest substance in the human body is moved by its ... a schnitzel, enormous strengths are working on the surface of ... also goes for dentures, inlays or bridges", glass chemist Prof. ... (Germany) says. After all, these are worn as much as ...
... 2012 Tengion, Inc. (NASDAQ: TNGN ... it has completed the relocation of its corporate ... existing facility in Winston-Salem, North Carolina. The relocation ... which was designed to fund the Company,s lead ...
... Jan. 5, 2012 Superior Controls, Inc. has been ... Control Engineering magazine. Each year, the worldwide competition ... exceptional technical expertise, business skills and customer satisfaction. ... 50 applications from industrial systems integrators throughout the ...
Cached Biology Technology:Nanocrystals make dentures shine 2Tengion Announces Relocation of Corporate Headquarters to Current Facility in Winston-Salem, North Carolina 2Tengion Announces Relocation of Corporate Headquarters to Current Facility in Winston-Salem, North Carolina 3Tengion Announces Relocation of Corporate Headquarters to Current Facility in Winston-Salem, North Carolina 4Superior Controls of Seabrook, NH Named System Integrator of the Year for 2012 by Control Engineering Magazine 2384 well block MBSr. Robot compatible block ejection mechanism. Stackable. (384 well block - holds 384 well plate)...
...
Buckets for 2 racks of 5 tubes, type Stago/Hitachi...
... The MBS Satellite Thermal ... and flexible solution for medium ... The MBS combines the latest ... friendly software and PC control, ...
Biology Products:| Copyright © 2003-2012 Bio-Medicine. All rights reserved. ABOUT | CONTACT US | DISCLAIMER | PRIVACY POLICY | TERMS AND CONDITIONS |  |