Navigation Links
Immune system response to viral DNA is unique

The human body has a unique immune system response to foreign DNA, suggesting that DNA viruses and RNA viruses are detected by different mechanisms, Yale School of Medicine researchers report this week in Immunity.

The researchers also found that DNA recognition might be used to detect invasive bacteria in addition to viruses, according to Daniel Stetson, a post doctoral fellow in the Section of Immunobiology and lead author of the study.

Although there are countless types of viruses, they can all be placed in two categories based on the type of nucleic acids that comprise their genome: viruses made of RNA and viruses made of DNA. Infected cells sense the presence of foreign nucleic acids as viruses replicate inside them and distill the problem of recognizing a dizzying array of viruses into a relatively simple mechanism for turning on the immune response.

"It is well established that such a pathway exists for detection of viral RNA inside infected cells," Stetson said. "In contrast, very little is known about whether cells can detect foreign intracellular DNA or how this system might function."

Stetson and Ruslan Medshitov, professor of immunobiology, a Howard Hughes Institute investigator, and senior author of the study, compared the innate immune response to intracellular DNA with other virus recognition pathways.

"We found that this novel pathway seems to function differently from all other known nucleic acid sensors," Stetson said. "The unique immune response activated by foreign DNA suggests that DNA viruses and RNA viruses are detected by different mechanisms."

Stetson said one important question raised by these findings is how this newly described system avoids responding to genomic DNA that is contained within all cells.

"If this 'tolerance' to self DNA were to break down, cells might mount an antiviral response against their own DNA," he said. "Further characterization of this pathway will shed light o
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. Immune systems distress signal tells bacteria when to strike back
7. New Lab Research May Help Those Deafened By Immune System Attack
8. Key To Stem Cell Transplant Success Is Tricking Immune System
9. Immune system has evolved to prevent autoimmune disease
10. Defective Gene Linked to Two Inherited Immune Deficiencies
11. How Dirt Could Educate The Immune System And Help Treat Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune system response viral DNA unique

(Date:8/28/2015)... 28, 2015 According to a ... by Assessment Type (Pen & Paper Based, Hosted, Biometrics), ... Learning, Academic Research), Vertical and Region - Global Forecast ... Market to grow from USD 2.4 Billion in 2015 ... Annual Growth Rate (CAGR) of 25.6% from 2015 to ...
(Date:8/20/2015)... , Aug. 20, 2015 The ... consumers that are active and healthy. However, wearable ... the hospital environment to help improve diagnostic capabilities ... video from the Wearable Technologies Conference 2015 ... new applications for wearables in healthcare.    ...
(Date:8/18/2015)... Aug. 17, 2015 Research and Markets ... the "Global Biometric Authentication & Identification Market: ... & Forecast, 2015-2020" report to their offering. ... identification systems market is expected to grow at ... 2020 and generate over $25 billion (approximately) by ...
Breaking Biology News(10 mins):Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 2Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 3Cognitive Assessment and Training Market Worth 7.5 Billion USD by 2020 4Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... project to create a next-generation cruise missile with the Office ... of the Defense Advanced Research Projects Agency (DARPA) stressed the ... Dr. Arati Prabhakar spoke at the 2012 ONR Naval ... the ONR/DARPA effort to develop a long-range anti-ship missile (LRASM) ...
... United States has largely been spared the scourge of mosquito-borne ... dengue fevermosquito-related illnesses in the US are on the rise. ... arbovirus known as West Nile. Now Qiang "Shawn" ... a professor in the College of Technology and Innovation has ...
... 2012 (BRONX, NY) The promise of stem cells ... repairing damaged spinal cords and restoring ravaged immune systems, these ... is still in its infancy, as scientists seek to better ... and disease. On Friday, September 14, the ...
Cached Biology News:DARPA director: 'Revolutionary weapons require strong S&T partnerships' 2Plants provide accurate low-cost alternative for diagnosis of West Nile Virus 2Plants provide accurate low-cost alternative for diagnosis of West Nile Virus 3Plants provide accurate low-cost alternative for diagnosis of West Nile Virus 4Plants provide accurate low-cost alternative for diagnosis of West Nile Virus 5Einstein hosts its first stem cell institute symposium 2Einstein hosts its first stem cell institute symposium 3
(Date:9/2/2015)... 2, 2015 Research and Markets ... of Jain PharmaBiotech,s new report "Nanobiotechnology ... offering. An increasing use ... industries is anticipated. Nanotechnology will be applied ... from formulations for optimal delivery to diagnostic ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... quality systems, analytical testing, education and consulting services for the medical device ... device products/processes development, design control, validation, quality assurance and regulatory compliance. Avarent ...
(Date:9/2/2015)... , Sep. 02, 2015 ... announced the addition of Jain PharmaBiotech,s new report ... to their offering. This report ... of sequencing technologies, and their applications. Current large ... companies developing them. Various applications of sequencing are ...
(Date:9/2/2015)... Sep. 02, 2015 ... the addition of Jain PharmaBiotech,s new report ... to their offering. This report ... technologies and applications. The report starts with a ... of markets. Technologies include array comparative genomic hybridization ...
Breaking Biology Technology:Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 2Global Nanobiotechnology Applications, Markets and Companies Report 2015-2024 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 2NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 3NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 4NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 5NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 6NSF International Strengthens Medical Device Consulting With Acquisition of Avarent LLC 7Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2Global Biochips and Microarrays Technologies, Markets and Companies Report 2015 with Market Size in 2014 and Projected Value for the Years 2019 and 2024 2
... A. How is fold amplification , ... using the Van Gelder and Eberwine technique (Van Gelder 1990) , ... polymerase , promoter for synthesis of ... at the end of mRNA sequences serves as the substrate for the , ...
... More thermostable than AMV RT and M-MLV RT , ... , Highly sensitive enzyme for ... for reverse transcribing transcripts with high , ... reverse transcriptase (RT) and , AMV RT, Ambion's HIV ...
... , Convenient format - premixed cap analog , ... RNA , 80% capping efficiency , ... , Ideal for microinjection, in vitro , ... The mMESSAGE mMACHINE High Yield , ...
Cached Biology Technology:RNA Amplification for Array Analysis 2RNA Amplification for Array Analysis 3RNA Amplification for Array Analysis 4Recombinant HIV Reverse Transcriptase 2Rapidly Synthesize Large Amounts of Capped RNA 2Rapidly Synthesize Large Amounts of Capped RNA 3Rapidly Synthesize Large Amounts of Capped RNA 4
XA7 B6...
... motor and ballscrew technologies, the ... solutions that include all the ... motors., , XY and ... high-flex cabling for power, signals, ...
Total Proteins from over 50 different human Alzheimer, Diabetic, Liver Cirrhosis, and Lupus diseased tissues are available....
...
Biology Products: