Navigation Links
Immune system response to viral DNA is unique

The human body has a unique immune system response to foreign DNA, suggesting that DNA viruses and RNA viruses are detected by different mechanisms, Yale School of Medicine researchers report this week in Immunity.

The researchers also found that DNA recognition might be used to detect invasive bacteria in addition to viruses, according to Daniel Stetson, a post doctoral fellow in the Section of Immunobiology and lead author of the study.

Although there are countless types of viruses, they can all be placed in two categories based on the type of nucleic acids that comprise their genome: viruses made of RNA and viruses made of DNA. Infected cells sense the presence of foreign nucleic acids as viruses replicate inside them and distill the problem of recognizing a dizzying array of viruses into a relatively simple mechanism for turning on the immune response.

"It is well established that such a pathway exists for detection of viral RNA inside infected cells," Stetson said. "In contrast, very little is known about whether cells can detect foreign intracellular DNA or how this system might function."

Stetson and Ruslan Medshitov, professor of immunobiology, a Howard Hughes Institute investigator, and senior author of the study, compared the innate immune response to intracellular DNA with other virus recognition pathways.

"We found that this novel pathway seems to function differently from all other known nucleic acid sensors," Stetson said. "The unique immune response activated by foreign DNA suggests that DNA viruses and RNA viruses are detected by different mechanisms."

Stetson said one important question raised by these findings is how this newly described system avoids responding to genomic DNA that is contained within all cells.

"If this 'tolerance' to self DNA were to break down, cells might mount an antiviral response against their own DNA," he said. "Further characterization of this pathway will shed light o n the mechanisms of antiviral responses and how cells discern viral and self-DNA."


'"/>

Source:Yale University


Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. Immune systems distress signal tells bacteria when to strike back
7. New Lab Research May Help Those Deafened By Immune System Attack
8. Key To Stem Cell Transplant Success Is Tricking Immune System
9. Immune system has evolved to prevent autoimmune disease
10. Defective Gene Linked to Two Inherited Immune Deficiencies
11. How Dirt Could Educate The Immune System And Help Treat Asthma
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/11/2016)... , March 11, 2016 http://www.apimages.com ) - ... reference: Picture is available at AP Images ( http://www.apimages.com ) - ... will be used to produce the new refugee identity cards. DERMALOG ... innovations, at CeBIT in Hanover next week.   ... DERMALOG will be used to produce the new refugee identity cards. ...
(Date:3/10/2016)... , March 10, 2016   Unisys Corporation ... and Border Protection (CBP) is testing its biometric identity ... San Diego to help identify certain non-U.S. citizens ... . The test, designed to help determine the efficiency and ... began in February and will run until May 2016. ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® , ... enrollment solutions, today announced the addition of smart ... Altus multi-factor authentication platform. New contextual and ... to step-up security where it,s needed most — ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:5/19/2016)... 19, 2016 There is no ... given the relentless pressures in pricing and lack in ... investors circle though - numerous opportunities are up for ... session, ActiveWallSt.com,s presents four names in this sector: Portola ... Inc. (NASDAQ: VTAE ), Anthera Pharmaceuticals Inc. ...
(Date:5/18/2016)... COLUMBIA, Md. (PRWEB) , ... May 18, 2016 ... ... new Shimadzu Pharmaceutical Sciences Summer Camp at The University of Toledo. This two-day ... school students an opportunity to explore the field of pharmaceutical sciences in preparation ...
(Date:5/18/2016)... ... ... Ryan Benton was diagnosed with Duchenne Muscular Dystrophy (DMD) at the age of ... is a relatively common progressive genetic disorder, which causes aggressive deterioration of the muscles. ... met with the founder of the Stem Cell Institute in Panama City, ...
(Date:5/17/2016)... ... May 17, 2016 , ... The Children’s Tumor Foundation is ... across the globe will show their support in the fight against neurofibromatosis (NF) by ... is a genetic disorder that causes tumors to grow on nerves throughout the body. ...
Breaking Biology Technology: