Navigation Links
Immune system response to viral DNA is unique

The human body has a unique immune system response to foreign DNA, suggesting that DNA viruses and RNA viruses are detected by different mechanisms, Yale School of Medicine researchers report this week in Immunity.

The researchers also found that DNA recognition might be used to detect invasive bacteria in addition to viruses, according to Daniel Stetson, a post doctoral fellow in the Section of Immunobiology and lead author of the study.

Although there are countless types of viruses, they can all be placed in two categories based on the type of nucleic acids that comprise their genome: viruses made of RNA and viruses made of DNA. Infected cells sense the presence of foreign nucleic acids as viruses replicate inside them and distill the problem of recognizing a dizzying array of viruses into a relatively simple mechanism for turning on the immune response.

"It is well established that such a pathway exists for detection of viral RNA inside infected cells," Stetson said. "In contrast, very little is known about whether cells can detect foreign intracellular DNA or how this system might function."

Stetson and Ruslan Medshitov, professor of immunobiology, a Howard Hughes Institute investigator, and senior author of the study, compared the innate immune response to intracellular DNA with other virus recognition pathways.

"We found that this novel pathway seems to function differently from all other known nucleic acid sensors," Stetson said. "The unique immune response activated by foreign DNA suggests that DNA viruses and RNA viruses are detected by different mechanisms."

Stetson said one important question raised by these findings is how this newly described system avoids responding to genomic DNA that is contained within all cells.

"If this 'tolerance' to self DNA were to break down, cells might mount an antiviral response against their own DNA," he said. "Further characterization of this pathway will shed light o n the mechanisms of antiviral responses and how cells discern viral and self-DNA."


'"/>

Source:Yale University


Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. Immune systems distress signal tells bacteria when to strike back
7. New Lab Research May Help Those Deafened By Immune System Attack
8. Key To Stem Cell Transplant Success Is Tricking Immune System
9. Immune system has evolved to prevent autoimmune disease
10. Defective Gene Linked to Two Inherited Immune Deficiencies
11. How Dirt Could Educate The Immune System And Help Treat Asthma
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
(Date:3/28/2017)... India , March 28, 2017 ... IP, Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software ... Vertical, and Region - Global Forecast to 2022", published ... Billion in 2016 and is projected to reach USD ... between 2017 and 2022. The base year considered for ...
(Date:3/24/2017)... , March 24, 2017 The Controller General of ... Mr. Abdulla Algeen have received the prestigious international IAIR Award ... Continue Reading ... ... and Deputy Controller Abdulla Algeen (small picture on the right) have received ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... , ... October 12, 2017 ... ... has launched Rosalind™, the first-ever genomics analysis platform specifically designed for life ... Named in honor of pioneering researcher Rosalind Franklin, who made a major ...
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ... pathology, announced today it will be hosting a Webinar titled, “Pathology is going ... Pathology Associates , on digital pathology adoption best practices and how Proscia improves ...
(Date:10/11/2017)... Florida (PRWEB) , ... October 11, 2017 , ... ... Drug Administration (FDA) has granted orphan drug designation to SBT-100, its novel anti-STAT3 ... for the treatment of osteosarcoma. SBT-100 is able to cross the cell membrane ...
(Date:10/10/2017)... 2017 International research firm Parks Associates announced today ... the TMA 2017 Annual Meeting , October 11 in ... home security market and how smart safety and security products impact the ... Parks Associates: Smart Home Devices: ... "The residential security market has experienced ...
Breaking Biology Technology: