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Immune system has evolved to prevent autoimmune disease

ds the human immune system evolved to minimize the risk of cross-reactivity. For example, each cell in our bodies contains about 100,000 proteins with an average of 500 amino acids apiece. Consequently, there are about one trillion potential docking sites, or epitopes, where antibodies could mistakenly attach themselves to proteins in a healthy cell. The mutation response method employed by our adaptive immune system seems keyed to this number, producing antibodies that are statistically likely to mistakenly bond with healthy proteins slightly less than one in a trillion times, meaning that on average, they recognize only invading pathogens.


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Source:Rice University


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