Navigation Links
Immune system has evolved to prevent autoimmune disease

tem's physical behavior at the molecular or atomic scale to build up a picture of the behavior at a larger level. In this case, Deem and postdoctoral researchers Jun Sun and David J. Earl studied the physical properties of fragments of DNA to determine the origins, behavior, and generation of antibodies.

Generating antibodies is one of the primary functions of the immune system. Antibodies are protein molecules that are made by B cells. Each antibody has a chemical signature that allows it to bind only with a particular sequence of amino acids.

"In our study, we first sought to understand the evolutionary rules that govern the way the immune system responds to an infection," Deem said. "With that framework in place, we identified a biologically-plausible strategy that would allow the immune system to react more quickly and with more effective antibodies. Our analysis revealed that such a system would be about 1,000 times more likely to produce antibodies that attack healthy tissues."

Antibodies that bind with something other than the antigen they evolved to attack are called cross-reactive, and some researchers believe cross-reactivity causes some autoimmune diseases.

For example, some scientists have found a correlation between chronic infection and an increased probability of autoimmune disease, but the strength and significance of the correlation is controversial. Rice's model suggests that a correlation does exist, but that the length of the infection prior to onset of autoimmune disease is highly variable.

"People have been looking for a clear, significant correlation in time, but a long distribution of onset times would lead to weaker statistical correlations, particularly in those cases where the infection persisted the longest," said Deem. "Searching for this distribution in health and medical statistics could shed light on this immunological puzzle and settle the scientific controversy."

The Rice analysis fin
'"/>

Source:Rice University


Page: 1 2 3

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. Immune systems distress signal tells bacteria when to strike back
7. New Lab Research May Help Those Deafened By Immune System Attack
8. Key To Stem Cell Transplant Success Is Tricking Immune System
9. Defective Gene Linked to Two Inherited Immune Deficiencies
10. How Dirt Could Educate The Immune System And Help Treat Asthma
11. Immune response to HIV in the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune system has evolved prevent autoimmune disease

(Date:7/9/2014)... a sparrow-sized fossil from China challenges the commonly held ... gained the ability to fly. The birdlike fossil is ... rather the remains of a tiny tree-climbing animal that ... Dinosaur Museum in Blanding, Utah, and Alan Feduccia of ... Springer,s Journal of Ornithology . , The fossil ...
(Date:7/9/2014)... of the amphibians with the highest distribution in the ... water where it comes into contact with the red ... out by the Spaniard Germn Orizaola from the University ... frogs have developed a defensive response to the invasive ... if they co-exist with the crayfish. , Numerous invasive ...
(Date:7/9/2014)... measurement results accrue. To completely and systematically archive ... In fact, researchers in the life sciences spend ... to an online survey of 70 people working ... for Applied Information Technology FIT in Sankt Augustin. ... no centralized or structured approach to data collection ...
Breaking Biology News(10 mins):Researchers declassify dinosaurs as being the great-great-grandparents of birds 2Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3Managing the data jungle 2Managing the data jungle 3
... The replanting of mangroves on the coasts of the Philippines ... 20-30 typhoons that hit the islands annually. This is ... immediate and massive mangrove replanting, that J.H. Primavera from the ... La Salle University, both in the Philippines, cite in a ...
... billion tons of microbial organismsexpressed in terms of carbon ... published online by Nature , July 20, 2008. ... of carbon stored globally in tropical rainforests. The authors: ... Marine Environmental Sciences (MARUM) at University of Bremen, Germany; ...
... of the nickel metal hydride (NiMH) technology used for ... hybrid gas-electric cars believes the hydrogen economy is already ... the current issue of the International Journal of ... and CEO of Ovshinsky Innovation LLC, based in Bloomfield ...
Cached Biology News:Mangroves key to saving lives 2Nature publishes new evidence about the deep biosphere written by biogeoscientists 2Nature publishes new evidence about the deep biosphere written by biogeoscientists 3Closing the hydrogen economic loop 2
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
(Date:1/14/2014)... USA, and Cardiff, UK (PRWEB) January 13, 2014 ... technology development leader with more than 20 years in ... for optics and photonics . Hainsey will serve as ... delighted to have Dr. Hainsey join SPIE as our ...
(Date:1/14/2014)... Independent publisher Bitingduck Press, with offices in Altadena ... ideas for 2014 in production and sales of interactive ... high-quality, low-cost, DRM-free ebooks and to use the sales ... first major development will be bookstore sales in local ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... PHILADELPHIA, May 28 Premier Research Group plc ... of Anthony Faragasso, MD as Executive Director and ... position, Dr. Faragasso will lead,the global Medical Management ... and safety services, Dr. Faragasso brings to ...
... ... Manufacturing Experience -, SAN DIEGO, May 28 ... Gordon H.,Busenbark to the company,s board of directors. Mr. Busenbark ... privately,held development-stage specialty pharmaceuticals company focused on,diseases of the central ...
... launch of a new collaborative website initially focusing on ... WikiProfessional technology underlying the site has been developed based ... open access journal Genome Biology, WikiProteins provides a method ... The article is written by Barend Mons of the ...
Cached Biology Technology:Premier Research Names Anthony Faragasso, MD as Executive Director and Global Head of Medical Management and Safety 2Nventa Appoints Gordon H. Busenbark to Board of Directors 2Large-scale community protein annotation -- WikiProteins 2
Request Info...
... the optimization of immunostaining. ... the primary antibody, selection and ... Alk. Phos., HRP, fluorescence, or ... evaluation by light or fluorescence ...
Ultra-sensitive, non-radioactive detection of Protein G. Measure Protein G levels quickly and easily....
Request Info...
Biology Products: