Navigation Links
Immune response to HIV in the brain

Using multi-disciplinary analysis that included cognitive, neurophysiologic, virologic, and molecular techniques, the team found both a low-level viral infection in the brain and immune cells that had infiltrated the brain in order to protect against the virus.

"As in the rest of the body, in the brain immune cells achieve a level of control of the virus, but are unable to clear the infection," says Howard Fox, associate professor at Scripps Research and director of Scripps NeuroAIDS Preclinical Studies center, who led the study. "Over the long-term, this immune response may act as a double-edged sword, protecting against rampant viral replication in the brain but leading to brain dysfunction."

The paper was published in the April 26 issue of the Journal of Neuroscience, the official journal of the Society of Neuroscience.

The study addresses a significant health problem. About one quarter to one third of all AIDS patients suffer from some form of central nervous system disorder in the course of their infection, ranging from minor cognitive and motor disorders to severe dementia, collectively known as neuroAIDS. Even subtle neurocognitive disorders limit quality of life with symptoms such as fatigue, and are correlated with difficulties ranging from a higher rate of traffic tickets to increased mortality.

In recent years, access to potent antiretroviral drugs in the United States and other developed countries has significantly improved the health, survival, and functioning of HIV-infected individuals. But since people are living longer with the virus, the overall prevalence of neuroAIDS appears to be increasing.

"Now that we're better at treating the immune/viral aspect of HIV, in many ways [AIDS] has turned into a chronic disease," says Fox. "The fact that many of the antiretroviral drugs do not show good penetration of the blood-brain barrier further puts the brain at risk, since the brain is infected soon after HIV exposu
'"/>

Source:Scripps Research Institute


Page: 1 2

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. Immune systems distress signal tells bacteria when to strike back
7. New Lab Research May Help Those Deafened By Immune System Attack
8. Key To Stem Cell Transplant Success Is Tricking Immune System
9. Immune system has evolved to prevent autoimmune disease
10. Defective Gene Linked to Two Inherited Immune Deficiencies
11. How Dirt Could Educate The Immune System And Help Treat Asthma
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Immune response HIV the brain

(Date:8/22/2014)... German . ... are fixated in a way so as to align ... and Fudan University researchers are planning on looking into ... findings are being published today in the scientific journal ... sensitive molecules. Everyone knows that at least from ...
(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
(Date:8/22/2014)... 2015, American consumers will finally be able to purchase ... touted as zero-emissions vehicles, most of the cars will ... fuel that contributes to global warming. , Now scientists ... that uses an ordinary AAA battery to produce hydrogen ... current through two electrodes that split liquid water into ...
Breaking Biology News(10 mins):Proteins: New class of materials discovered 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 2Stanford scientists develop a water splitter that runs on an ordinary AAA battery 3
... A team of researchers, led by biologists at Dartmouth, ... in Lake Baiyangdian, the largest lake in the North ... drinking water for the people who live around it. ... Lake Baiyangdian, all at varying distances from major sources ...
... Is getting new knees on your list of New ... indicates that women wait longer to pursue knee-replacement surgery ... can no longer stand the pain, these women may ... on hold indefinitely, according to Lynn Snyder-Mackler, Distinguished Alumni ...
... If youre worried about high cholesterol levels and keeping ... and eggs just yet. A new study says they ... University have discovered that lower cholesterol levels can actually ... assistant professor of health and kinesiology, and Simon Sheather, ...
Cached Biology News:Dartmouth researchers alarmed by levels of mercury and arsenic in Chinese freshwater ecosystem 2Listen-up ladies: Don't postpone knee-replacement surgery 2Listen-up ladies: Don't postpone knee-replacement surgery 3Surprise -- cholesterol may actually pose benefits, study shows 2
(Date:8/22/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced results for the ... 2014 second quarter financial statements and MD&A have been filed on SEDAR ... , Six-months ended June 30, ( in CDN$,000 except per ... 2014 , 2013 Revenue , 2,459 , ... , 56 , 1,485 , 385 ...
(Date:8/22/2014)... published today (August 22nd), in the scientific journal ... Neuroscience Programme establish the effect of serotonin on ... genetic and optical techniques., "Serotonin is a small ... range of brain functions, from the control of ... emotional behaviours, This neurotransmitter is also popularly thought ...
(Date:8/22/2014)... Nanometre-scale gold particles are intensively investigated for ... biological contrast agents and components in photonics ... atomic-scale structures, fundamental for understanding physical and ... at Stanford University, USA, have demonstrated that ... reveal a three-dimensional structure in which all ...
(Date:8/22/2014)... Texas (PRWEB) August 22, 2014 The ... and in-depth study on the current state of the ... report provides a basic overview of the industry, including ... and Chinese domestic market analysis are provided with a ... the market. A comparison between the international and Chinese ...
Breaking Biology Technology:Biorem Reports 2014 Second Quarter Results 2Biorem Reports 2014 Second Quarter Results 3From happiness to pain: Understanding serotonin's function 2A breakthrough in imaging gold nanoparticles to atomic resolution by electron microscopy 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 2Diabetes Drugs Industry Growth Analysis in Global, China Regions Research Report Available at DeepResearchReports.com 3
... insight, discipline, and a relentless focus on developing technology, ... high-value company by defining a big problem with a ... products. Neah Power Systems is a company ... , ,Neah is a successful fuel cell company ...
... announced today it has been chosen again to ... Wisconsin-Madisons Camp Randall Stadium and Kohl Center arena. The ... South Dakota-based company in the early 1990s. The value ... to be complete before the start of the 2004 ...
... today that it is the only Wisconsin member of North ... United Training is a consortium of independently owned ... who have met an extremely high set of standards to ... to qualify for membership, Inacom was recognized by its peers, ...
Cached Biology Technology:Neah Power Systems A seed stage venture capital model 2Neah Power Systems A seed stage venture capital model 3Neah Power Systems A seed stage venture capital model 4Neah Power Systems A seed stage venture capital model 5Daktronics to provide Camp Randall and Kohl Center with scoreboards, display systems 2
... Precision-designed for Optimal Microdissection , CapSure HS ... precise and rapid extraction of populations of ... samples with Laser Capture Microdissection., Ensure ... Molecular Analysis , All CapSure LCM Caps ...
... Microdissection , CapSure HS and CapSure Macro ... extraction of populations of pure cells from ... Capture Microdissection., Ensure the Integrity of ... All CapSure LCM Caps have a patented ...
... Precision-designed for Optimal Microdissection , CapSure ... the precise and rapid extraction of populations ... cytology samples with Laser Capture Microdissection., ... Downstream Molecular Analysis , All CapSure LCM ...
... Microdissection , CapSure HS and CapSure Macro ... extraction of populations of pure cells from ... Capture Microdissection., Ensure the Integrity of ... All CapSure LCM Caps have a patented ...
Biology Products: