Navigation Links
Immune cell communication key to hunting viruses, Jefferson immunologists show

ace of T-cells with receptors recognizing the viral-MHC complex, the control ?a biosensor that carried the same MHC protein with a different peptide not recognized by the T- cells ?unexpectedly also binded almost as strongly. "When we have such an arrangement of MHC proteins, we were able to see something no one had seen before ?a very strong contribution of non-viral peptide-MHC interaction with a co-receptor," he says. "Such cooperativity we think can be achieved when MHC complexes are close to each other.

"We've shown that when we try to mimic the positioning of MHC protein on quantum dots, which we believe is similar to what it is on the cell membrane, we have this very strong binding. An important message is that a single virus-MHC complex recognized in the context of self-MHC complexes is sufficient to activate a T-cell response, which is amazing," he says. "That's the power of killer cells.

"We always suspected that recognition of other peptide MHCs, like self-peptide MHCs derived from normal proteins, could facilitate recognition, but it was not clear until now how this happened." Dr. Sykulev notes that this finding is not only relevant to viral infected cells, but to tumor cells as well. Both usually express very low levels of proteins that killer cells recognize.
'"/>

Source:Thomas Jefferson University


Page: 1 2

Related biology news :

1. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
2. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
3. First North American Encapsulated Islet Transplant without Long-term Immune Suppression into a Patient with Type 1 Diabetes
4. Newly Discovered Branding Process Helps Immune System Cells Pick Their Fights
5. How A Latent Virus Eludes Immune Defenses
6. Immune systems distress signal tells bacteria when to strike back
7. New Lab Research May Help Those Deafened By Immune System Attack
8. Key To Stem Cell Transplant Success Is Tricking Immune System
9. Immune system has evolved to prevent autoimmune disease
10. Defective Gene Linked to Two Inherited Immune Deficiencies
11. How Dirt Could Educate The Immune System And Help Treat Asthma
Post Your Comments:
(Date:2/5/2015)... TRIANGLE PARK, North Carolina , 5. ... sein 35. Jahr als spezialisiertes Logistikunternehmen und ... Position als einzige klinische Logistikfirma (Clinical Logistics ... Die Kernbotschaft der neuen Kampagne lautet ... und Lieferungen. Foto: http://photos.prnewswire.com/prnh/20150205/173753 ...
(Date:2/5/2015)... Calif. , Jan. 27, 2015 /PRNewswire/ ... provider of globally deployed, innovative test solutions ... announced the delivery of its TS-323 ... Space Systems Company (LMSSC). GENASYS is a ... demands of mission-critical applications that require performance ...
(Date:2/5/2015)...  It is gratifying to see that the Obama ... science as a means to better understand human biology, ... was honored to participate in today,s White House event ... Since the 1980s my teams have been ... sequenced genome of a free living organism, the first ...
Breaking Biology News(10 mins):Marken startet Kampagne mit Patienten im Mittelpunkt 2Marken startet Kampagne mit Patienten im Mittelpunkt 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 2Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 3Marvin Test Solutions' GENASYS Platform Advances Mission-Critical Aerospace Production Test 4J. Craig Venter, Ph.D., Co-Founder and CEO, Human Longevity, Inc. (HLI) Participates in White House Precision Medicine Event 2
... Therapeutic hypothermia has been proven to reduce mortality and ... was rarely used in a sample of more than ... Hypothermia and Temperature Management, a peer-reviewed journal published by ... www.liebertpub.com/ther Therapeutic hyperthermia was used in ...
... The American Association of Anatomists, 2012 Basmajian Award will ... professor in the department of cell biology, neurobiology and ... ceremony will take place at the AAA Annual Meeting ... Marquis & Marina, San Diego, CA)., This award recognizes ...
... Life (EOL, www.eol.org ) continues to expand at a ... At the start of 2012, EOL provides data on nearly ... rich information about conservation issues from the International Union for ... and videos than ever before. In the four ...
Cached Biology News:Todd Hoagland honored by Anatomy Society for excellence in teaching, research & scholarship 2The Encyclopedia of Life expanding at a record pace 2
(Date:3/5/2015)... BioPlus Specialty Pharmacy (BioPlus) announces the hiring ... of Managed Care. In this role, Damm will build ... nation’s leading specialty pharmacies. , Damm, who is based ... pharmacy and biotech experience to his new position with ... and Pfizer. Prior to working in Healthcare Damm served ...
(Date:3/5/2015)... Park, NC (PRWEB) March 05, 2015 ... announced that Pierre Noel, M.D., Professor of Medicine, ... to the Company’s Board of Directors. ... “We are extremely fortunate to have Dr. Noel, ... country’s leading healthcare organization, join Entegrion’s Board. His ...
(Date:3/5/2015)... Conn. , March 5, 2015  UBM ... , a leading online community to help ... of the newest information available regarding the use ... of kidney cancer. March is ... are very few effective adjuvant treatment options for ...
(Date:3/5/2015)...  In response to the incorrect assertions by LD, ... on February 12, 2015. Impeto Medical SAS and ... and their SUDOSCAN® devices have been proven to provide ... to have the courts decide this dispute rather than ... articles written by Key Opinion Leaders, published by significant ...
Breaking Biology Technology:BioPlus Specialty Pharmacy Announces Hiring of New Vice President of Managed Care: Jamie Damm 2Entegrion Announces Appointment of Pierre Noel, MD, to Its Board of Directors 2OncoTherapy Network Highlights Kidney Cancer Awareness Month 2OncoTherapy Network Highlights Kidney Cancer Awareness Month 3Impeto Medical Responds to Published Allegations by LD Technology LLC ("LD") 2
... First Clinical Milestone Validates Approach, SAN FRANCISCO, ... completion of its first clinical trial, a,proof-of-concept study ... sodium channel blocker. Rufinamide was discovered and,developed by ... Europe as a,drug to treat a form of ...
... January 22 Progentix,Orthobiology B.V. announced today the ... was led by BioGeneration Ventures., Progentix Orthobiology ... suite of osteoinductive material products for clinical application,in ... based on,surface structured ceramic biomaterial scaffolds that have ...
... year the NorTech Venture,Capital Advisory Task Force reported in ... need to generate and attract over $1.2 billion,in venture ... needs of companies,located in Northeast Ohio. According to the ... the Cleveland+ region, to be,released in print mid February, ...
Cached Biology Technology:Synosia Announces Encouraging Results of Proof-of-Concept Clinical Trial for Epilepsy Drug rufinamide as a Treatment for Mood Disorders 2Synosia Announces Encouraging Results of Proof-of-Concept Clinical Trial for Epilepsy Drug rufinamide as a Treatment for Mood Disorders 3Progentix Orthobiology B.V. Closes Series A Financing Round 2Cleveland+ Region Attracts $318 Million in New Venture Investment in 2007 2Cleveland+ Region Attracts $318 Million in New Venture Investment in 2007 3Cleveland+ Region Attracts $318 Million in New Venture Investment in 2007 4Cleveland+ Region Attracts $318 Million in New Venture Investment in 2007 5
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
...
[14C]Polyethylene glycol 4000, 9.25 MBq, 250 uCi. Aqueous solution containing 3% ethanol, sterilized. 370-740 MBq/g, 10-20 mCi/g.1.85 MBq/ml, 50 uCi/ml. Category: Radiochemicals &Radiation Safety, ...
Use the DUALmembrane kit 3 to carry out DUALmembrane interaction analysis and cDNA library screening to characterize interactions between integral membrane proteins and to identify novel interaction ...
Biology Products: