Navigation Links
Imaging study links key genetic risk for Alzheimer's disease to myelin breakdown

A new UCLA imaging study shows that age-related breakdown of myelin, the fatty insulation coating the brain's internal wiring, correlates strongly with the presence of a key genetic risk factor for Alzheimer disease.

The findings are detailed in the January edition of the peer-reviewed journal Archives of General Psychiatry and add to a growing body of evidence that myelin breakdown is a key contributor to the onset of Alzheimer disease later in life.

In addition, the study demonstrates how genetic testing coupled with non-invasive evaluation of myelin breakdown through magnetic resonance imaging (MRI) may prove useful in assessing treatments for preventing the disease.

"Myelination, a process uniquely built up in humans, arguably is the most important and most vulnerable process of brain development as we mature and age. These new findings offer, for the first time, compelling genetic evidence that myelin breakdown underlies both the advanced age and the principal genetic risks for Alzheimer disease," said Dr. George Bartzokis, professor of neurology at UCLA's David Geffen School of Medicine.

"The human brain functions as a high-speed Internet system," said Bartzokis, director of the UCLA Memory Disorders and Alzheimer Disease Clinic and Clinical Core director of the UCLA Alzheimer Disease Research Center. "The quality of the brain's connections is key to its speed, bandwidth, fidelity and overall on-line capability."

Myelin is a sheet of lipid, or fat, with very high cholesterol content -- the highest of any brain tissue. The high cholesterol content allows myelin to wrap tightly around axons, speeding messages through the brain by insulating these neural "wire" connections.

As the brain continues to develop in adulthood and as myelin is produced in greater and greater quantities, cholesterol levels in the brain increase and eventually promote the production of a toxic protein that attacks the brain. The protein attac
'"/>

Source:University of California - Los Angeles


Page: 1 2

Related biology news :

1. Imaging Lymph Nodes with Nanoparticles
2. Special Imaging Study Shows Failing Hearts Are Energy Starved
3. Imaging techniques permit scientists to follow a day -- or four -- in the life of a cell
4. Imaging pinpoints brain regions that see the future
5. Bioartificial kidney under study at MCG
6. W.M. Keck Foundation funds study of friendly microbes
7. Yellowstone microbes fueled by hydrogen, according to U. of Colorado study
8. Genome-wide mouse study yields link to human leukemia
9. Clam embryo study shows pollutant mixture adversely affects nerve cell development
10. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
11. Same mutation aided evolution in many fish species, Stanford study finds
Post Your Comments:
(Date:12/10/2014)... RALEIGH, N.C. , Dec. 9, 2014  Valencell, ... announced it is seeing a staggering demand from its ... demand, the Company revealed, is not solely coming from ... industries as well. "A wearable is only ... a result, accuracy is the ultimate driver in long-term ...
(Date:12/5/2014)... , Dec. 4, 2014 Increased emphasis ... investments in new testing and inspection technologies. The ... rise to a range of innovative test solutions. ... of Generation Y, which is generally more inclined ... result, product development strategies of test equipment vendors ...
(Date:11/21/2014)... , November 18, 2014 ... Systems Market by Systems (Video, RFID, Access Control, Intrusion ... Factories, Hotels, Banks, Government), Component Service Geography - Global ... Systems Market is projected to be around $25 Billion ... by 2020, growing at a CAGR of 8.69%. ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... It seems the old nature versus nurture debate can,t be ... the Philippines makes a strong case for nurture,s role in ... in the first six months of life predicts earlier puberty ... babies -- an indication that they were not nutritionally stressed ...
... tread of a pesky fly landing on your face may strike ... small annoyances. But for scientists working to develop pressure sensors ... sensitive enough to feel the tickle of fly feet would be ... sensor. By sandwiching a precisely molded, highly elastic rubber ...
... Ariz. Arizona State University,s expanding research, education ... has led to formation of the Center for ... recently approved establishment of the center, which will ... engineering, physics, materials science and engineering, and bioengineering. ...
Cached Biology News:Male maturity shaped by early nutrition 2Male maturity shaped by early nutrition 3New artificial skin could make prosthetic limbs and robots more sensitive 2New artificial skin could make prosthetic limbs and robots more sensitive 3Focus on photonics 2
(Date:12/17/2014)... (PRWEB) December 17, 2014 Gene ... that it has entered into a technology access ... (ADM) to apply DNA2.0’s proprietary protein engineering technology, ... process. , “We are extremely excited that the ... platform. This proprietary bioengineering technology has now ...
(Date:12/17/2014)... SOUTH SAN FRANCISCO, Calif. , Dec. 17, ... positive results of a Phase 2 study evaluating ... for the treatment of patients with severe, chronic ... the current standard of care, including topical steroids ... endpoint was percent change in Visual Analog Scale ...
(Date:12/15/2014)...  GlassesOff Inc. (OTCBB: GLSO) announced today the appointment ... director of the Company,s Board of Directors. ... its CEO until its acquisition by Stanley Black ... Recognized as the inventor of the first Wi-Fi-based Active ... -based RFID solutions focused on improving operational efficiency, safety ...
(Date:12/13/2014)... (PRWEB) December 12, 2014 Clarassance, a ... announced its new name: Therabron Therapeutics , Inc. ... and bronchioles (a type of structure in the lungs ... company’s mission to develop novel protein therapeutics for the ... directors decided to change the name to mark the ...
Breaking Biology Technology:ADM and DNA2.0 Enter Into Protein Engineering Technology Access and Service Agreement 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 2Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 3Velocity Pharmaceutical Development, LLC and Tigercat Pharma, Inc. Announce Phase 2 Results for VPD-737 in Patients With Chronic Pruritus 4AeroScout Founder Joins GlassesOff's Board of Directors 2AeroScout Founder Joins GlassesOff's Board of Directors 3Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... -- GE Healthcare's LightSpeed VCT, the world's ... today by the Wall Street Journal ... global Technology Innovation Awards. The annual awards recognize ... the world in a wide range of areas, ...
... bicycle industry by buying some of the most traditional, ... company has jumped full speed into the future with ... its systems. , ,The company, which owns such traditional ... names such as GT and Mongoose, finds itself on ...
... women entrepreneurs? , ,The market is good for their ... and the revenue from them has increased faster than the ... less likely to fail, too, experts say. , ,Finding money ... , ,The problem is not limited to Wisconsin, but is ...
Cached Biology Technology:Pacific Cycle rides full speed into RFID 2Pacific Cycle rides full speed into RFID 3Women and Capital: Two words that dont always marry 2Women and Capital: Two words that dont always marry 3Women and Capital: Two words that dont always marry 4
... Concept in Microarrays: Biomedical Photometrics Inc. (Waterloo, ... (Jena, Germany) have collaborated to develop a ... System. The DNAscope AT is based ... DNAscope AT automatically reads up to six ...
Complement factor B (human)...
Best pricing for 100mg-1.0g scales. Phosphopeptides are our specialty....
... 10 Capillary Electrophoresis Running Buffer was designed ... throughput demands of todays sequencing labs. As ... TBE to the gel-based sequencing community Sigma ... capacity to meet your buffer needs. Scientists ...
Biology Products: