Navigation Links
Image of myosin-actin interaction revealed in cover story of Molecular Cell

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction. The culmination of four years of work, this collaboration among biochemists and structural biologists was selected as the cover story for the September issue of the scientific journal Molecular Cell.

The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction. Using electron-cryo microscopy to take 3D snapshots of myosin V and actin interacting, researchers were able to see myosin V moving along the actin substrate in a "natural state." Previous 2D models have been based on staining or other treatment of the myosin that might alter the complex's natural mechanism of action.

Myosins are a large family of motor proteins that interact with actin filaments for motor movement and muscle contraction. Myosin V is the workhorse of the myosin protein family. It exists to ferry a cargo of proteins needed in a specific place at a specific time. Fueled by hydrolysis -- the process of converting the molecule adenosine triphosphate (ATP) into energy -- myosin V travels in one direction using actin as a track to deliver its payload of cell vesicles and organelles. Myosin V is also involved in transporting proteins that signal and communicate with other cells.

Myosin V has a two-chained "tail" that diverges to form two "heads" that bind to specific grooves on actin and walk hand over hand along the track, similar to the way a child moves along the monkey bars in a playground. Myosin V differs from the other myosin family proteins in that it is able to sustain this processive motion, enduring man
'"/>

Source:Burnham Institute


Page: 1 2 3

Related biology news :

1. Virus-host interactions at sea effect global photosynthesis
2. Future diabetes drugs may target new protein interaction
3. Computational verification of protein-protein interactions by orthologous co-expression
4. Confirmation of human protein interaction data by human expression data
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Complex gene interactions account for autism risk
7. A real time look at interactions between RNA and proteins
8. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
9. Biologists visualize protein interaction that may initiate viral infection
10. Biologists develop genome-wide map of miRNA-mRNA interactions
11. Mans best friend: Study shows lonely seniors prefer playtime with pooch over human interaction
Post Your Comments:
(Date:7/27/2015)... , July 27, 2015  Synaptics Inc. ... human interface solutions, today announced that Huawei has ... touchscreen solution for its stylish smartwatch. Huawei chose ... proven reliability, low power and highly responsive human ... finger. Huawei designers also required a classic round ...
(Date:7/23/2015)... 2015 Aware, Inc. (NASDAQ: AWRE ), a ... results for its second quarter ended June 30, 2015.  ... $4.5 million, a decrease of 33% compared to $6.8 million ... second quarter of 2015 was $0.3 million, or $0.01 per ... diluted share, in the same period a year ago.  ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, featuring FPC,s ... in 2015 that relate to sales of FPC1025 for this smartphone ... MSEK for 2015. Jörgen Lantto, CEO of FPC, comments: ... China and we are proud that ... Axon , its first smartphone ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2
... (SACRAMENTO, Calif.) In what researchers say is the ... method to prevent West Nile virus, a UC Davis ... during and immediately after aerial sprayings in the summer ... from the California Department of Public Health found no ...
... a better understanding of these effects, researchers from the ... Laboratoire de recherche en cardiovasculaire, mtabolisme, diabtologie et nutrition ... mixed with low doses of dioxin, PCB, bisphenol A ... already been rendered obese by a high-fat diet. , ...
... have developed a new method for visualizing material defects ... led by Bert Nickel has, for the first time, ... thin-film solar cells using laser light for localized excitation ... scientific journal " Advanced Materials ". "We have developed ...
Cached Biology News:Aerial mosquito spraying study finds no immediate public health risks 2Aerial mosquito spraying study finds no immediate public health risks 3Food contaminants worsen metabolic problems in obese mice 2Organic electronics: Imaging defects in solar cells 2
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, ... launch of their 2nd generation cell therapy POD® design. The 2nd generation portfolio ... also represents a new POD® design. , “G-CON first offered our miniPOD ...
(Date:7/29/2015)... , July 29, 2015  Therapath Neuropathology ( ... increased partnerships with VA and Military Medical centers ... Fiber Density (ENFD) and Sweat Gland Nerve Fiber ... neuropathy ( https://therapath.com/skin ). Demonstration ... Density (ENFD) on punch skin biopsy is a ...
(Date:7/29/2015)... 29, 2015 /PRNewswire/ - RepliCel Life Sciences Inc. (OTCQB: ... company, is pleased to announce that the final design ... been locked.  Prototypes for industrial and regulatory testing ... application for CE mark clearance to market the ... 2016. (Photo: http://photos.prnewswire.com/prnh/20150729/248373 )  ...
(Date:7/29/2015)... ... July 29, 2015 , ... Available ... NIGHT Express Contouring Bi-Gel, a nighttime-specific product that targets fat cells for extreme ... are able to enter fat cells, inhibiting the formation of new fat. Upon ...
Breaking Biology Technology:G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Neuropathology services for VA and Military health systems 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3
... car consists of 193 different types of steel. The steel ... and optimised. It is important, for example, that all parts ... whereas other parts of the car have to be super ... Super strong nanostructured metals are now entering the scene, ...
... July 21, 2011 Boehringer Ingelheim Pharmaceuticals, Inc. ... capsules has been added to hospital formularies at 49 of ... by U.S. News & World Report,s Best Hospitals ... the U.S. Food and Drug Administration (FDA) to reduce the ...
... Md., July 21, 2011 United Therapeutics Corporation (NASDAQ: ... release its second quarter 2011 financial results before market ... Therapeutics will host a half-hour teleconference on Thursday, July ... is accessible by dialing 1-877-351-5881, with international callers dialing ...
Cached Biology Technology:A new discovery paves the way for using super strong nanostructured metals in cars 2A new discovery paves the way for using super strong nanostructured metals in cars 3Pradaxa® (dabigatran etexilate mesylate) Capsules Now on Formulary at Nation's Top Heart Hospitals 2Pradaxa® (dabigatran etexilate mesylate) Capsules Now on Formulary at Nation's Top Heart Hospitals 3Pradaxa® (dabigatran etexilate mesylate) Capsules Now on Formulary at Nation's Top Heart Hospitals 4Pradaxa® (dabigatran etexilate mesylate) Capsules Now on Formulary at Nation's Top Heart Hospitals 5Pradaxa® (dabigatran etexilate mesylate) Capsules Now on Formulary at Nation's Top Heart Hospitals 6
... Although the mixed TAMRA isomers are predominantly ... are increasingly preferred for labeling peptides and ... HPLC purification that is often required in ... used than 6-TAMRA for labeling peptides and ...
Rabbit polyclonal to GPCR G2A ( Abpromise for all tested applications). entrezGeneID: 29933 SwissProtID: Q9UNW8...
Alkali soluble casein is the recommended blot blocking reagent for use with the HisTag Monoclonal Antibody (Novagen) on Western blots....
Ephrin A4...
Biology Products: