Navigation Links
Image of myosin-actin interaction revealed in cover story of Molecular Cell

Scientists from the Burnham Institute for Medical Research and the University of Vermont have captured the first 3-dimensional (3D) atomic-resolution images of the motor protein myosin V as it "walks" along other proteins, revealing new structural insights that advance the current model of protein motility and muscle contraction. The culmination of four years of work, this collaboration among biochemists and structural biologists was selected as the cover story for the September issue of the scientific journal Molecular Cell.

The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction. Using electron-cryo microscopy to take 3D snapshots of myosin V and actin interacting, researchers were able to see myosin V moving along the actin substrate in a "natural state." Previous 2D models have been based on staining or other treatment of the myosin that might alter the complex's natural mechanism of action.

Myosins are a large family of motor proteins that interact with actin filaments for motor movement and muscle contraction. Myosin V is the workhorse of the myosin protein family. It exists to ferry a cargo of proteins needed in a specific place at a specific time. Fueled by hydrolysis -- the process of converting the molecule adenosine triphosphate (ATP) into energy -- myosin V travels in one direction using actin as a track to deliver its payload of cell vesicles and organelles. Myosin V is also involved in transporting proteins that signal and communicate with other cells.

Myosin V has a two-chained "tail" that diverges to form two "heads" that bind to specific grooves on actin and walk hand over hand along the track, similar to the way a child moves along the monkey bars in a playground. Myosin V differs from the other myosin family proteins in that it is able to sustain this processive motion, enduring man
'"/>

Source:Burnham Institute


Page: 1 2 3

Related biology news :

1. Virus-host interactions at sea effect global photosynthesis
2. Future diabetes drugs may target new protein interaction
3. Computational verification of protein-protein interactions by orthologous co-expression
4. Confirmation of human protein interaction data by human expression data
5. Physical and functional interaction of key cell growth molecules linked to cancer
6. Complex gene interactions account for autism risk
7. A real time look at interactions between RNA and proteins
8. U of MN researchers develop way to visualize synchronized interactions of nerve cells in the brain
9. Biologists visualize protein interaction that may initiate viral infection
10. Biologists develop genome-wide map of miRNA-mRNA interactions
11. Mans best friend: Study shows lonely seniors prefer playtime with pooch over human interaction
Post Your Comments:
(Date:7/9/2014)... Sexual selection refers to species, selection for traits ... type of natural selection enhances opportunities to mate, the ... Biologists at the University of California, Riverside have now ... of a placenta are linked. Describing the life ... the family Poeciliidae, the researchers found that species with ...
(Date:7/9/2014)... July 9, 2014Biofuels derived from the oils produced by ... fuels. To achieve this goal, optimization of cost effective ... pond systems, is needed. Sapphire Energy has developed an ... pond algae cultivation systems, described in Industrial Biotechnology ... publishers. The article is available on the Industrial ...
(Date:7/9/2014)... Guelph scientist that involved fitting bumblebees with tiny ... neonicotinoid pesticide hampers bees, ability to forage for ... professor in Guelph,s School of Environmental Sciences, and ... July 9 in the British Ecological Society,s journal ... how long-term pesticide exposure affects individual bees, day-to-day ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Controlling contamination in open algae ponds for biofuels 2Bee foraging chronically impaired by pesticide exposure: Study 2
... Assist with Solutions and Services to Support U.S. Army,s ... International Inc (NYSE: CAI ) announced today ... support the U.S. Army,s Biometrics Task Force. CACI received ... and Support Services - Unrestricted (BOSS-U) contract vehicle. The ...
... strategic farming practices might be part of the solution ... on 15 January in Current Biology , a ... reflect sunlight back out to space, summertime temperatures could ... much of central North America and mid-latitude Eurasia. That ...
... Mean Time / 13:00 Eastern Standard Time (TORONTO): Scientists ... have detected evidence that DNA may not be the ... called epigenetics may also account for some inherited traits ... of genetics and inheritance, and potentially provide a new ...
Cached Biology News:CACI Awarded a Prime Position on $500 Million, Multiple-Award Program with Biometrics Operations and Support Services 2CACI Awarded a Prime Position on $500 Million, Multiple-Award Program with Biometrics Operations and Support Services 3CACI Awarded a Prime Position on $500 Million, Multiple-Award Program with Biometrics Operations and Support Services 4Strategic farming practices could help mitigate global warming 2Rethinking the genetic theory of inheritance 2
(Date:1/14/2014)... (PRWEB) January 14, 2014 In recent ... motives and methods in product development and promotion has ... industry. This mistrust, fueled by concerns about the insidious ... by reports of spectacular fines to the world’s biggest ...
(Date:1/14/2014)... 14, 2014 Global Record Systems, ... information technology solutions for patients, physicians, the biopharmaceutical ... announced today the signing of a three-year Research ... Drug Administration (FDA). This initiative is designed ...
(Date:1/14/2014)... Cardiff, UK (PRWEB) January 13, 2014 ... leader with more than 20 years in the industry, ... and photonics . Hainsey will serve as the society’s ... have Dr. Hainsey join SPIE as our Technology Strategist, ...
(Date:1/14/2014)... January 14, 2014 During the 1600’s through ... as “The Doctor’s Plague.” In this time period, doctors did ... led, at times, to the death of vulnerable patients. In ... know that they may be unwittingly transmitting herpes viruses to ...
Breaking Biology Technology:The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... , the leading meeting place for buyers and sellers ... Pharma Sourcing Conference to be held December 6-7, 2011 ... The two day program will be jointly hosted by ... issues that global chemical and pharmaceutical industry players are ...
... 26, 2011 Immune Design Corp. (IDC), a ... immunotherapies for infectious disease, cancer and allergy, announced ... research collaboration with Sanofi-Aventis to investigate the use ... toll–like receptor 4 (TLR-4) agonist, in the field ...
... RICHMOND, Calif., Oct. 25, 2011 Sangamo BioSciences, Inc. (Nasdaq: ... results and accomplishments. For the third quarter ... of $9.6 million, or $0.18 per share, compared to a ... the same period in 2010. As of September 30, 2011, ...
Cached Biology Technology:Informex Introduces a Thorough Global Pharma Perspectives Conference 2Sangamo BioSciences Reports Third Quarter 2011 Financial Results 2Sangamo BioSciences Reports Third Quarter 2011 Financial Results 3Sangamo BioSciences Reports Third Quarter 2011 Financial Results 4Sangamo BioSciences Reports Third Quarter 2011 Financial Results 5Sangamo BioSciences Reports Third Quarter 2011 Financial Results 6
GOAT ANTI HUMAN PSA (ISOFORM 1)...
Human Carnosine Dipeptidase 1 Affinity Purified PAb...
... and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the ... surface of endothelial cells at sites of ... of PSGL-1 in mediating the interaction between ... completely blocks recognition of PSGL-1 by either ...
Mouse Anti-Human MCAF-(MCP-1)...
Biology Products: