Navigation Links
Identical twins may have more differences than meet the eye

asn't true for the oldest pairs of twins. Genetically speaking, these twins were the least alike.

The process that alters gene expression and behavior without changing a gene's DNA sequence is called methylation. Plass, who is also part of the human cancer genetics program at Ohio State, studies methylation in both normal and cancer cells in hopes of better understanding how the process affects the beginning and progression of the disease.

"Methylation is important for normal cellular development," Plass said. "It can help protect the integrity of a DNA sequence. But certain changes in the regulation of DNA methylation could have fatal consequences for a cell or individual."

Identical twins are born with an identical set of genes. Studying genetic differences in twins may give Plass and his colleagues insight into how methylation is regulated.

"One would expect identical twins to develop and express genes at the same levels, but in fact this changes over time," Plass said. "We think that methylation plays a genome-wide role in these changes."

Scientists think that foods, exposure to chemicals, physical activity levels and aging may all contribute to methylation in cells. But they don't understand how changes in DNA methylation occur, or how the process is regulated.

The DNA analysis in this study showed that twins who had spent less of their lives together, or had greater differences in their health and medical histories, had the greatest amount of methylation.

The next step for Plass is to compare the findings of this study to what he sees in cancer cell cultures in his laboratory.

"Nearly every tumor, every human malignancy shows changes in DNA methylation that mess up gene expression," he said. "If we understand what regulates methylation patterns, then we may be able to develop better treatment options for cancer."

The researchers received financial support for this work from the Foundation
'"/>

Source:Ohio State University


Page: 1 2 3

Related biology news :

1. UCLA scientists discover immune response to HIV differs, even in identical twins
2. How can identical twins be genetically different?
3. Study finds that a womans chances of having twins can be modified by diet
4. Variation in womens X chromosomes may explain differences among individuals, between sexes
5. Big differences in duplicated DNA distinguish chimp and human genomes
6. Study outlines genetic differences between potential pandemic influenza strains
7. Brain differences could explain why males and females experience pain relief differently
8. Most human-chimp differences due to gene regulation ?not genes
9. Albatross study shows regional differences in ocean contamination
10. Viral genetic differences are possible key to HIV dementia
11. New brain-chemistry differences found in depressed women
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Identical twins may have more differences than meet the eye

(Date:1/22/2015)... Jan. 22, 2015   EyeLock, Inc. , a market leader ... Steve Gerber to the new role of Senior ... for leading development of mobile platforms and wearable solutions for ... and innovation in the semiconductor industry to his role at ...
(Date:12/24/2014)... , Dec. 23, 2014  Since its launch in December 2014, the ... eliminate the pain of trying to remember their usernames and ... fused to their smartphones. To assist people who have struggled ... company that created 1U and focuses on redefining identity, announced ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3The Global Watermarking and Fingerprinting Markets 2
... BioScience includes the following peer-reviewed articles: Molecular ... Patrick J. Tranel and David P. Horvath. , Modern ... development of herbicide-resistant crops and a better understanding of ... of tools, including genomics, could yield novel and still ...
... system response that is critical to the first stages ... an entirely different direction than most scientists had thought, ... University Medical Center. "This finding will have ... development," said Michael Gunn, M.D., an immunologist and cardiologist ...
... Christopher Fasano (Memorial Sloan-Kettering Cancer Center) and colleagues lend ... stem cells outside of the neurogenic niche. , ... Bmi-1, maintains forebrain neural stem cell self-renewal. Overexpression of ... increases stem cell self-renewal both in vitro and in ...
Cached Biology News:BioScience tip sheet, March 2009 2New origin found for a critical immune response 2
(Date:1/22/2015)... 22, 2015 Protocol Networks brings independent ... team of brand-neutral, independent consultants, Protocol Networks has recently ... that over the years, his company has attracted several ... of Plainfield, as well as others. With the success ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Dr. Greg Leyer ... 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics in ... is an annual continuing education conference for health care professionals. ... included the topic of probiotics in health. Dr. Leyer spoke ...
(Date:1/22/2015)... Nueva Jersey , 22 de enero de 2015  El ... abre hoy su llamada a nominaciones para 2015. Este ... ha hecho, o tiene el potencial para hacer, contribuciones ... nominaciones se aceptarán hasta el 15 de marzo de ...
(Date:1/22/2015)... 22, 2015  Derma Sciences, Inc. (Nasdaq: ... advanced wound care, announces that AMNIOEXCEL® and AMNIOMATRIX®, ... added to the Premier, Inc. Regenerative Skin Grafting ... the AMNIOEXCEL® and AMNIOMATRIX® product lines, which continue ...
Breaking Biology Technology:Protocol Networks Brings Independent Technology Consulting to the Constitution State 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... This release from ... -- or even whether -- invasive saltcedar should be controlled. The Society contends that ... and carefully weigh the impact of our decisions. , ... Lawrence, KS (PRWEB) August 24, 2009 -- Saltcedar (Tamarix spp.) is ...
... LEIDEN, The Netherlands and SEATTLE, August ... innovative products for hemostasis and,regenerative medicine, today announced the ... The financing round was led by new investor,Gilde Healthcare ... investor Index Ventures. Dirk Kersten from Gilde will join ...
... , SEATTLE, Aug. 21 Cell ... closing of its previously announced sale of $30 million of shares ... of its common stock in a registered offering to a single ... its shares of Series 2 Preferred Stock and to receive the ...
Cached Biology Technology:Invasive Saltcedar Triggers Lively Debate among Weed Scientists and Land Managers 2Invasive Saltcedar Triggers Lively Debate among Weed Scientists and Land Managers 3ProFibrix Raises US $11 Million (EUR 8 million) in Series B Financing 2ProFibrix Raises US $11 Million (EUR 8 million) in Series B Financing 3Cell Therapeutics, Inc. Announces Closing of Registered Offering of $30 Million of Preferred Stock and Warrants 2
... One can operate as a Voltage Clamp, as ... Clamp in electrophysiology research applications. Performance in any ... equipment. • This amazing ... in the capabilities of Digital Signal Processing (DSP) ...
... an enhanced ChemStation for the ... 2000 and Windows XP operating ... all new 7500 ICP-MS instruments ... new ChemStation using Microsofts Windows ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Soil Nematode microRNA Microarray ...
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
Biology Products: