Navigation Links
Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine.

Though multiple genetic alterations are associated with melanoma development, scientists have not been able to establish a direct causal link between these alterations and human cancer growth. Determining whether these mutations have the potential themselves to induce cancer or simply play a supporting role also has been difficult.

To determine the impact of genetic alterations associated with human melanoma, Yakov Chudnovsky; his advisor, Paul Khavari; postdoctoral fellow Amy Adams, and colleagues generated human skin tissue containing cells selectively engineered to express specific mutations found in melanoma. They report their findings in the June 12, 2005, issue of the journal Nature Genetics, offering clues to the oncogenic potency of several genes implicated in the development of melanoma.

Melanoma is the deadliest form of skin cancer, resulting from the malignant transformation of cells called melanocytes. Over the past four decades, the incidence of melanoma has risen 15-fold, a more rapid increase than that of any other cancer.

"The only current treatment is early detection and excision," Chudnovsky said. "But no treatment can substantially enhance patient survival once metastasis has occurred."

To simulate the environment in which melanoma naturally arises, the research team introduced one or more cancer-associated genes into human melanocytes, the pigment-producing cells that normally reside in the deepest layer of the skin. The genetically engineered melanocytes were then combined with keratinocytes, the cells that give skin its structure, to form a sample of human skin that was grafted onto laboratory mice. The mice were observed for
'"/>

Source:http://www.nottingham.ac.uk/


Page: 1 2 3

Related biology news :

1. Adding Radiation Therapy To Chemotherapy Improves Survival In Patients With High-risk Breast Cancer
2. Another Look Finds Promising Proteomics Test is Not Biologically Plausible
3. Elephants imitate truck noises, other animals
4. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
5. NJIT Presidential Award winner takes stem cell research another step
6. New Treatment Rivals Chemotherapy For Lymphoma, Study Finds
7. NASA links nanobacteria to kidney stones and other diseases
8. Anti cancer virotherapy well tolerated in first human administration, research finds
9. Bevacizumab Combined With Chemotherapy Improves Progression-Free Survival for Patients With Advanced Breast Cancer
10. Report that delayed motherhood decreases life expectancy of mouse offspring
11. Rhesus monkeys can assess the visual perspective of others when competing for food
Post Your Comments:
(Date:5/22/2013)... Adventitious changes in cellular DNA can endanger the whole ... cancer. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich now report ... the double helix. , The DNA in our cells ... in our bodies. The instructions for this are encoded ... in DNA, the bases adenine (A), cytosine (C), guanine ...
(Date:5/22/2013)... NEW YORK, May 22, 2013. Plastic additives known ... just about everywhere: They turn up in flooring, ... andaccording to the Centers for Disease Control and ... harmless, phthalates have come under increasing scrutiny. A ... phthalates (which can leech from packaging and mix ...
(Date:5/21/2013)... the body, stem cells in the blood often ... mature immune cells that can fight off illness. ... cell populations, potentially leading to the development of ... team of researchers led by biologists at the ... in mouse models, the molecule microRNA-146a (miR-146a) acts ...
Breaking Biology News(10 mins):DNA damage: The dark side of respiration 2Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2Keeping stem cells strong 2
... Tufts University today announced the public launch of the ... The Institute is university-wide, global pharmaceutical ... portfolio of drug discovery and development partnerships. ... Tufts University School of Medicine and Tufts University,s Advancement ...
... FASEB MARC (Minority Access to Research Careers) Program ... American College of Sports Medicine (ACSM) Southeast Chapter Annual ... awards are meant to promote the entry of underrepresented ... the basic science community and to encourage the participation ...
... it,s messy, smelly and typically problematic. Live bait is inconvenient ... more permanent lures, you run the risk of losing an ... of brightly colored plastic familiar from your father,s tackle box, ... Professor John Caprio and Mystic Tackleworks have changed all that ...
Cached Biology News:Tufts announces public launch of the Tufts Institute for Biomedical Partnerships website/HUB 2Tufts announces public launch of the Tufts Institute for Biomedical Partnerships website/HUB 3LSU biologist, chemical engineer partner with industry to develop best soft lure available 2LSU biologist, chemical engineer partner with industry to develop best soft lure available 3LSU biologist, chemical engineer partner with industry to develop best soft lure available 4
(Date:5/23/2013)... -- Northwest Biotherapeutics (NASDAQ: NWBO ) (NW ... immune therapies for solid tumor cancers, announced today that ... Society Of Clinical Oncology (ASCO) meeting in ... immune therapy.  (Logo: http://photos.prnewswire.com/prnh/20110329/SF73084LOGO ) ... conference focused on clinical treatment of cancer, with attendance ...
(Date:5/23/2013)... May 23, 2013  Verenium Corporation (Nasdaq: ... the development and commercialization of high-performance enzymes, today announced ... Officer, will present at two upcoming conferences. ... present at the Second Annual Marcum LLP Microcap Conference ... Hotel in New York City.  The presentation is scheduled ...
(Date:5/23/2013)... May 23, 2013 SynCardia Systems, Inc. ... only FDA, Health Canada and CE (Europe) approved Total ... in Scotland, which boasts more than 380,000 visitors annually, ... powered by the Freedom® portable driver as part ... most advanced exhibitions of its kind. , “BodyWorks ...
(Date:5/23/2013)... Bed bugs compromised Penn State. ... confirmed it. Meanwhile, My Cleaning Products offered complimentary samples of ... the pests without using harmful chemical elements. , Based ... the affected building was actually a dormitory , My ... made on May 13 and bed bug presence was confirmed ...
Breaking Biology Technology:NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 2NW Bio Exhibit at the Upcoming ASCO Meeting to Highlight its Leadership Role in Immune Therapy for Cancer 3Verenium To Present At Two Upcoming Conferences 2Verenium To Present At Two Upcoming Conferences 3SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 2SynCardia Total Artificial Heart Featured in $3 Million Exhibition at Glasgow Science Centre 3Penn State Dorm Infested with Bed Bugs, My Cleaning Products Offers Complimentary Sample of Bed Bug Spray to Help Bed Bug Victims 2
... America,Inc. (OTC Bulletin Board: CBAI), the umbilical cord ... focused on,bringing the life saving potential of stem ... revenues for 2007 totaled $5.8,million, up 74 percent ... of an adjustment in how we recognized yearly ...
... Institute of Standards and Technology (NIST) have combined ... single microchip, a cryogenic sensor and a microrefrigerator. ... and faster precision analysis of materials such as ... upcoming issue of Applied Physics Letters,* the NIST ...
... Mr. Glynn has over 34 years of,combined financial, ... the life sciences industry for his role in the ... Glynn,retired from Invitrogen Corporation (Nasdaq: IVGN ) in ... several operating roles including CFO,President and COO and CEO. ...
Cached Biology Technology:Cord Blood America Reports $5.8 Million In Revenues In 2007, Up 74 Percent 2NIST micro sensor and micro fridge make cool pair 2eBioscience Corporation Announced Today That James Glynn Has Been Appointed to Its Board of Directors, Effective April 15, 2008 2
Mouse monoclonal [B314.1 (MAC 387)] to Macrophage L1 protein Calprotectin (rating: ****) ( Abpromise for all tested applications)....
MOUSE ANTI HUMAN CYTOKERATIN 1-8...
Request Info...
... Ether 30% concentration in ... Surfactant. Clear Solution. Recommended ... 1 mL of 30% ... to 400 mL of ...
Biology Products: