Navigation Links
Huntington's cure in flies lays groundwork for broader treatment approaches

Boosting levels of two critical proteins that normally shut down during Huntington's disease, researchers at the University of Wisconsin-Madison and the Cold Spring Harbor Laboratory have cured fruit flies of the genetic, neurodegenerative condition.

Forms of the same proteins-known in short form as CREB and HSP-70--exist in all cells, including those of humans.

The study results, published online today by the Proceedings of the National Academy of Sciences, were a "logical finding" because of a growing body of work in the area, says senior author Jerry Yin, a UW-Madison molecular geneticist. Scientists previously knew, for example, that hiking the activity of either CREB or HSP-70 lessened symptoms in mice or flies with Huntington's disease.

Completely reversing a disease by targeting a combination of proteins or genetic pathways, however, reflects the growing need to embrace a broader treatment paradigm in the realm of genetic disorders, says Yin.

In working with a disorder such as Fragile X Syndrome, for example, conventional therapies might focus all their efforts on repairing the genetic pathways that cause neurons to go awry. Meanwhile, "the defective gene is not just in one type of tissue," says Yin. "And we are not yet sensitive to detecting the defects in those other tissues."

Rather than focusing treatment strategies on single genetic pathways, then, Yin believes a promising alternative might be to simultaneously target a cocktail of gene-induced activities - all of which are set in motion, for example, by a single faulty gene.

Yin has long worked in the area of "triplet expansion" diseases such as Huntington's and Fragile X, in which genes go haywire due to a coding defect. His collaborators on the recent fruit fly work include, among others, lead author Kanae Iijima-Ando of the Cold Spring Harbor Laboratory and UW-Madison assistant scientist Eric Drier.

Working with the simplistic genetics of flies i s certainly a long way from the complex realities of humans, Yin says, particularly for diseases that can be attributed to dozens and even hundreds of abnormal gene functions.

Yet in some cases, it might turn out that gene pathways stemming from different genes converge at some point, into one common "superhighway," says Yin. "If you know that, you can do something in the superhighway part," he says.

Researchers studying epilepsy, for example, have discovered that at least 20 genes have a role to play in the onset of seizures, and dozens more may be involved. Though many might argue for directing research dollars to the continued search for epilepsy genes, Yin believes funding agencies should now consider investing in the search for these "superhighways" of gene convergence.

That search might be long and tedious, he adds, but it's most certainly worth a shot. "I think the history of scientific discovery teaches us that we can't predict anything. So we just have to play all the cards we can possibly play."


'"/>

Source:University of Wisconsin-Madison


Related biology news :

1. U. Iowa researchers improve Huntingtons disease symptoms in mice
2. New insights into how Huntingtons disease attacks the brain
3. Molecular trigger for Huntingtons disease found
4. Old drug shows new promise for Huntingtons Disease
5. MIT research holds promise for Huntingtons treatment
6. Gene therapy injected into the brains of mice with Huntingtons disease
7. Test reveals effectiveness of potential Huntingtons disease drugs
8. New technology to speed up research into Huntingtons disease
9. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
10. Master gene controls healing of skin in fruit flies and mammals
11. Remote control flies? Fly behavior controlled by laser light
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
(Date:3/29/2017)... CHICAGO , March 29, 2017  higi, the ... ecosystem in North America , today ... Partners and the acquisition of EveryMove. The new investment ... extensive set of tools to transform population health activities ... and lifestyle data. higi collects and secures ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Global ... to 2025" report to their offering. ... The Global Biometric Vehicle Access System Market ... the next decade to reach approximately $1,580 million by 2025. ... for all the given segments on global as well as regional ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... wash is a basic first aid supply for any work environment, but most personal eye ... first if a dangerous substance enters both eyes? It’s one less decision, and likely quicker ... eye piece. , “Whether its dirt and debris, or an acid or alkali, getting anything ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... ... October 10, 2017 , ... San Diego-based team building and cooking ... initiative announced today. The bold new look is part of a transformation to ... into a significant growth period. , It will also expand its service offering from ...
(Date:10/10/2017)... Oct. 10, 2017 International research firm Parks Associates ... speak at the TMA 2017 Annual Meeting , October 11 in ... the residential home security market and how smart safety and security products ... Parks Associates: Smart ... "The residential security market ...
Breaking Biology Technology: