Navigation Links
Huntington's cure in flies lays groundwork for broader treatment approaches

Boosting levels of two critical proteins that normally shut down during Huntington's disease, researchers at the University of Wisconsin-Madison and the Cold Spring Harbor Laboratory have cured fruit flies of the genetic, neurodegenerative condition.

Forms of the same proteins-known in short form as CREB and HSP-70--exist in all cells, including those of humans.

The study results, published online today by the Proceedings of the National Academy of Sciences, were a "logical finding" because of a growing body of work in the area, says senior author Jerry Yin, a UW-Madison molecular geneticist. Scientists previously knew, for example, that hiking the activity of either CREB or HSP-70 lessened symptoms in mice or flies with Huntington's disease.

Completely reversing a disease by targeting a combination of proteins or genetic pathways, however, reflects the growing need to embrace a broader treatment paradigm in the realm of genetic disorders, says Yin.

In working with a disorder such as Fragile X Syndrome, for example, conventional therapies might focus all their efforts on repairing the genetic pathways that cause neurons to go awry. Meanwhile, "the defective gene is not just in one type of tissue," says Yin. "And we are not yet sensitive to detecting the defects in those other tissues."

Rather than focusing treatment strategies on single genetic pathways, then, Yin believes a promising alternative might be to simultaneously target a cocktail of gene-induced activities - all of which are set in motion, for example, by a single faulty gene.

Yin has long worked in the area of "triplet expansion" diseases such as Huntington's and Fragile X, in which genes go haywire due to a coding defect. His collaborators on the recent fruit fly work include, among others, lead author Kanae Iijima-Ando of the Cold Spring Harbor Laboratory and UW-Madison assistant scientist Eric Drier.

Working with the simplistic genetics of flies i
'"/>

Source:University of Wisconsin-Madison


Page: 1 2

Related biology news :

1. U. Iowa researchers improve Huntingtons disease symptoms in mice
2. New insights into how Huntingtons disease attacks the brain
3. Molecular trigger for Huntingtons disease found
4. Old drug shows new promise for Huntingtons Disease
5. MIT research holds promise for Huntingtons treatment
6. Gene therapy injected into the brains of mice with Huntingtons disease
7. Test reveals effectiveness of potential Huntingtons disease drugs
8. New technology to speed up research into Huntingtons disease
9. Proteasome activator enhances survival of Huntingtons disease neuronal model cells
10. Master gene controls healing of skin in fruit flies and mammals
11. Remote control flies? Fly behavior controlled by laser light
Post Your Comments:
(Date:11/21/2014)... C-Labs LLC, a leading provider of remote ... today announced the appointment of John Traynor ... strategic advisor to the firm, Mr. Traynor will now ... based out of the C-Labs office in ... Muench , Chief Executive Officer. Photo - ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure ... Industry Association today jointly announce the formation of ... release of its Identity and Biometric Entry ... The Framework received official support from BORDERPOL, the ... to improve and provide expertise regarding border security, ...
(Date:11/18/2014)... Md. , Nov. 17, 2014 The Parenteral ... and U.S. regulatory agencies will speak and at least seven ... Metrics Conference at the Omni Shoreham Hotel in ... pleased once again to have significant support from the regulatory ... Europe in our effort to help ...
Breaking Biology News(10 mins):C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2
... Atlantic right whale's future looks grim if the current ... professor of oceanography Douglas Nowacek and a group of ... co-authored a paper titled "North Atlantic Right Whales in ... the journal Science. , In it, Nowacek and his ...
... the final step in the completion of new blood vessel ... Diego (UCSD) School of Medicine team in research that promises ... by cutting off the tumor blood supply. , The research ... at UCSD and a member of the Rebecca and John ...
... Scientists may have found a way to dramatically slow ... , That's the promising implication of an animal study ... at Birmingham (UAB) and the University of Florida (UF) ... the National Academy of Sciences. , The research team ...
Cached Biology News:FSU scientist warns North Atlantic right whale facing extinction 2Unexpected lock and key mechanism found for the assembly of tumor blood vessels 2Unexpected lock and key mechanism found for the assembly of tumor blood vessels 3Discoveries by UAB and Florida scientists may help transplanted organs survive longer 2
(Date:11/22/2014)... 2014   , ... Officer zu KLOX    ... Financial Officer bestellt    KLOX ist ... jüngst zugelassenen Behandlungssystems zur Wundheilung zu beginnen    , ... ist sehr erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... 20, 2014 Author Matthew J. Pallamary’s ... the Other Side” published as a tribute to ... the “Fiction: Short Story” category of the 2014 ... and CEO of USA Book News, said this year’s ... publishers, including Simon & Schuster, Penguin, John Wiley & ...
(Date:11/21/2014)... November 21, 2014 Why did Stephen ... Albert Einstein so instantly recognizable? Why have they become ... astronomer and author Hilton Ratcliffe seeks out the answers ... at all to do with science. In " Stephen ... , November 21, 2014), Ratcliffe puts it plainly: ...
(Date:11/21/2014)... YORK and SAN DIEGO , ... ), today announced that President and CEO Marc Hedrick , ... DATE:   Thursday, December 4, 2014 TIME: ... Click here or paste this URL into your ... recommended that investors pre-register to save time and receive event ...
Breaking Biology Technology:KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 2Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 3Cytori Therapeutics to Provide Corporate Update and Investor Presentation on December 4 through a Live, Interactive Webcast 4
... to ICD and CRT-D ... device ... BSX ) today announced a new clinical science initiative,ALTITUDE, which will ... the substantial LATITUDE data to,seek answers to common questions related to ...
... May 15 Human Genome Sciences,Inc. (Nasdaq: ... has joined the,Company as Vice President, Hepatology Franchise. ... Hematology, Genentech Corporation, will,report to Barry A. Labinger, ... http://www.newscom.com/cgi-bin/prnh/20080416/HGSLOGO ), "Kevin McRaith brings ...
... QUEBEC CITY, May 15 /PRNewswire-FirstCall/ - AEterna Zentaris ... biopharmaceutical company focused on,endocrine therapy and oncology, today ... Officer, Dennis Turpin, CA, will present a,company overview ... Global,Healthcare Conference on Tuesday, May 20, 2008 at ...
Cached Biology Technology:Boston Scientific Announces Program to Analyze Latitude(R) Patient Monitoring Data 2Boston Scientific Announces Program to Analyze Latitude(R) Patient Monitoring Data 3Boston Scientific Announces Program to Analyze Latitude(R) Patient Monitoring Data 4Human Genome Sciences Names Kevin P. McRaith Vice President, Hepatology Franchise 2Human Genome Sciences Names Kevin P. McRaith Vice President, Hepatology Franchise 3AEterna Zentaris to Present at Upcoming Rodman & Renshaw Global Healthcare Conference and AUA Annual Meeting 2
... carry-over contamination, which prevents false positive ... from previous PCR amplifications without degrading ... amplification ,Optimized for use with GeneAmp ... systems , The GeneAmp PCR Carry-over ...
... enzyme that catalyzes the conversion,of starch ... maltotriose and,dextrins. The level of a-amylase ... are of clinical importance,1-3 while plant ... industry.4, The EnzChek Amylase Assay Kit ...
... that catalyzes the hydrolysis of,starch to ... dextrins. The,level of a-amylase in various ... of,clinical significance in the diagnosis of ... and microbial a-amylases are,important enzymes for ...
Rat monoclonal [20d5] to NKG2A + C+ E ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Mouse): CHO transfected cells expressing the B6 allele of NKG2A. Entrez Gen...
Biology Products: