Navigation Links
Hunt for human genes involved in cell division under way

A systematic search through human genes has begun at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Working within the MitoCheck consortium that includes 10 other institutes throughout Europe, the EMBL scientists will silence all human genes, one-by-one, to find those involved in cell division (mitosis) and to answer fundamental questions of how cell division is regulated.

The scientists will use a method called 'RNA interference (RNAi)' where chemically synthesized RNA molecules are used to target and silence each human gene. About 22,000 genes will be suppressed and their impact on cell division monitored by live cell microscopy to understand each gene's role in cell division.

"To our knowledge, we are the first group to take on this systematic search through the genome in live cells. We will use the most potent RNAi reagent for this study, which is usually out of reach for academic labs because of the enormous cost and the ever-changing annotation of the human genome. But being part of the large EU project MitoCheck allowed us to work with one of the leading suppliers of siRNAs, Ambion Europe, Ltd., to produce a genome-wide library for this project," says Dr. Jan Ellenberg, EMBL Group Leader and co-initiator of the MitoCheck project.

Undertaking such a large project required tens of thousands of siRNA molecules, as two to three molecules are targeted specifically against each human gene. EMBL chose Ambion as a supplier of the siRNA library because its library could be tailored to the most up-to-date list of human target genes ?a list provided by the Wellcome Trust Sanger Institute, the MitoCheck bioinformatics partner. Also, Ambion's siRNA libraries utilize a siRNA design algorithm developed by Cenix BioScience GmbH (an EMBL spin-off company), leading to high efficacy of the siRNAs.

"We are happy to work with Ambion and Cenix BioScience on this ambitious project. This represents the first use of a genome-wi
'"/>

Source:European Molecular Biology Laboratory


Page: 1 2

Related biology news :

1. Novel technology detects human DNA mutations
2. Current human embryonic stem cell lines contaminated UCSD/Salk team finds
3. UWs Rosetta software to unlock secrets of many human proteins
4. Genome-wide mouse study yields link to human leukemia
5. Found: Missing sequence of the human Y chromosome
6. Study finds more than one-third of human genome regulated by RNA
7. Molecular machine may lead to new drugs to combat human diseases
8. Sea skate experiment sheds light on human cell transport
9. Mouse brain tumors mimic those in human genetic disorder
10. Zebrafish may hold key to understanding human nerve cell development
11. Yale researchers identify molecule for detecting parasitic infection in humans
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Hunt for human genes involved cell division under way

(Date:9/29/2014)... Gourmet pizza in school? According to a new Food ... , chef-made meals can increase participation in the National ... and consumption of vegetables by 16%! , Chefs Move ... Move campaign, pairs chefs with schools in order to ... interested school food service workers. , A CMTS event ...
(Date:9/29/2014)... research team says recently identified radiation detection properties of ... doors for homeland security and medical advances. , In ... issue of Optics Letters , UT Arlington Physics ... method to fabricate transparent nanoscintillators by heating nanoparticles composed ... is formed. A scintillator refers to a material ...
(Date:9/29/2014)... Wis. Mountain pine beetles get a bad rap, ... killing pine trees over tens of millions of acres ... decade. , But contrary to popular belief, these ... wildfires like those that have recently swept through the ... in the ecological severity of fires than these bark-boring ...
Breaking Biology News(10 mins):Chefs move to schools can increase school meal participation and vegetable intake among students 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 2UT Arlington researchers develop new transparent nanoscintillators for radiation detection 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 2Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 3Tree killers, yes, fire starters, no: Mountain pine beetles get a bad rap, study says 4
... 15, 2011 DigitalPersona, Inc. ... protection solutions, today announced the availability of its ... manufacturers and solution providers. FingerJet OEM offers MINEX-certified ... fast one-to-many identification and one-to-one verification. The software ...
... A $7.5 million award will help researchers harness ... create new types of antidotes for exposure to pesticides ... Institutes of Health (NIH), extends a previous grant and ... University, where chemists will collaborate with the U.S. Army ...
... and other particulate matter in the atmosphere can strongly ... dry regions or seasons. This while increasing rain, ... regions or seasons, according to results of a new ... of how aerosols--soot, dust and other particulates in the ...
Cached Biology News:DigitalPersona Announces FingerJet OEM Fingerprint Recognition Software for Biometric Device Manufacturers and Solution Providers 2DigitalPersona Announces FingerJet OEM Fingerprint Recognition Software for Biometric Device Manufacturers and Solution Providers 3Researchers get $7.5M grant to combat nerve agents 2Researchers get $7.5M grant to combat nerve agents 3Air pollution a culprit in worsening drought and flooding 2Air pollution a culprit in worsening drought and flooding 3Air pollution a culprit in worsening drought and flooding 4
(Date:9/30/2014)... September 30, 2014 SoundConnect, ... collaboration company is dedicated to supporting business communication ... Julie Power, a carrier services ... collaboration solutions stays connected and productive at all ... increased movement of businesses to cloud communications services. ...
(Date:9/30/2014)... Whitehouse Laboratories is pleased to ... Parenteral Drug Association (PDA) to host a unique ... closure integrity testing. This lecture/laboratory course will examine the ... detailed in the recently proposed revision to USP 1207 ... will span container closure integrity testing (leak testing) critical ...
(Date:9/29/2014)... the forefront of diagnostics today, with imaging techniques ... scanning, and NMR (nuclear magnetic resonance) increasing steeply ... of image resolution and quality still limit these ... A solution is hyperpolarization, which involves injecting the ... by following the distribution and fate of specific ...
(Date:9/29/2014)... - Portage Biotech Inc. ("Portage" or "the Company") (OTC: PTGEF, ... its three Promissory Note holders, two of whom are ... in July 2014 for a total of $ 300,000 ... into 3,500,001 restricted common shares. Notes were repayable within ... and the coupon were convertible into common shares to ...
Breaking Biology Technology:SoundConnect Expands Carrier Services Division 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4A safer approach for diagnostic medical imaging 2A safer approach for diagnostic medical imaging 3Portage announces conversion of its debt into equity 2Portage announces conversion of its debt into equity 3
... 23 A bill designed to,strengthen energy cooperation ... Senate Foreign Relations Committee, is a positive step ... States to promote the production,and use of sustainable ... Industry Association (UNICA)., "It shows a clear ...
... BioInformatics, LLC,( http://www.gene2drug.com ), the leading ... science industry, announces the publication of its ... Chemists and,Biologists." A joint effort between BioInformatics, ... is designed to help suppliers of protein,research ...
... Expertise in Chromogranin A Tumor Detection Marker Technology Now ... Applied ... a member of IBA group and a developer and marketer ... the launch,of its chromogranin A ELISA diagnostic tool, Chromoa. This ...
Cached Biology Technology:New Bill to Expand Promotion of Biofuels Is a Welcome Boost for U.S.-Brazil Relations According to Brazilian Sugarcane Industry 2New Bill to Expand Promotion of Biofuels Is a Welcome Boost for U.S.-Brazil Relations According to Brazilian Sugarcane Industry 3Protein Research Marketing Insights 2Protein Research Marketing Insights 3CISBIO Bioassays Launches Chromoa(TM) Chromogranin A ELISA Kit 2
EML1 (K-16)...
Bovine Coronary Artery Smooth Muscle Cells (BCASMC) (>500,000 cells)...
Bovine Aortic Smooth Muscle Cells (BAOSMC) (>500,000 cells)...
... adapter allows the Thermo-Fast® ... AB-1000) PCR plates to ... ABI PRISM® 3700 capillary ... for information on the ...
Biology Products: