Navigation Links
Human testis harbors HIV-1 in resident immune cells

Researchers have demonstrated HIV replication within resident immune cells of the testis, providing an explanation for the persistence of virus in semen even after effective highly active antiretroviral therapy. The related report by Roulet et al., “Susceptibility of human testis to human immunodeficiency virus-1 infection in situ and in vitro,?appears in the December issue of The American Journal of Pathology.

According to the most recent World Health Organization data, 39.5 million people are infected with HIV. Semen remains the main means of spreading the virus, even though highly active antiretroviral therapy (HAART) can successfully suppress virus in the blood. The presence of HIV in the semen despite successful HAART has intrigued scientists.

Researchers led by Dr. Nathalie Dejucq-Rainsford examined testis tissue for the presence of HIV receptors. They found that all of the necessary cellular receptors (CD4, CXCR4, CCR5, and DC-SIGN) were present on cells located within the testis, specifically testicular macrophages.

The point was demonstrated further by using explanted organ cultures in which human testis tissue was grown in culture. This testis culture, which retained the same tissue architecture as in vivo tissue and continued to secrete testosterone, was able to support infection by HIV-1. Virus produced from the testis culture was fully active as collected virus was able to infect permissive cells in culture.

The finding that HIV-1 can replicate within testicular macrophages is significant because the testis represents a pharmacological sanctuary—many anti-retroviral drugs have difficulty penetrating this organ and may be present at sub-therapeutic levels. Thus, although HAART may achieve undetectable virus levels in the blood, virus replication in the testis may permit continued spread of the virus.

Finally, with HIV infection continuing to rise, the development of anti-retroviral therapy that effectiv
'"/>

Source:American Journal of Pathology


Page: 1 2

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. New Clues Add 40,000 Years to Age of Human Species
3. Human Cells Filmed Instantly Messaging for First Time
4. Govt Creates Gene Database of Normal Human Tissues
5. Analysis Of Human Genome To Predict The Development Of Illnesses
6. Human Eggs Can Develop From Ovarian Surface Cells In Vitro
7. Determining The Fate Of Cells In The Human Body
8. Whole genome promoter mapping - Human Genome Project v2.0?
9. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
10. Going To Extremes To Improve Human Health
11. Human brain is still evolving
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Human testis harbors HIV resident immune cells

(Date:5/24/2013)... Studying complex systems like ecosystems can get messy, especially ... big unknowns like climate change. , In a ... Proceedings of the National Academy of Sciences , ... a fundamental assumption at the very heart of a ... To model how climate changes may impact biodiversity, researchers ...
(Date:5/24/2013)... frequently expressed concern in the ongoing public health debate ... those that are nutrient dense. A new study, ... Most Nutrients Per Penny," published in the journal ... the best nutritional values in the produce aisle, providing ... most other raw vegetables and delivering one of the ...
(Date:5/24/2013)... of the world,s largest and fastest growing open-access publishers, ... Frontiers in Physics . , A broad scope journal ... provide an open-science and interactive web platform for the ... articles. , Frontiers, real-time and interactive peer-review enables ... article types. With an average of three months from ...
Breaking Biology News(10 mins):Understanding the past and predicting the future by looking across space and time 2New research shows that potatoes provide one of the best nutritional values per penny 2Frontiers launches new open-access journal in physics 2Frontiers launches new open-access journal in physics 3
... Salts Emerging as New Recreational Drugs, (#1120069, Wednesday, ... bath salts as recreational drugs has greatly escalated in ... Sciences Center in Oklahoma City, Oklahoma describe an incident ... who also exhibited violent behavior upon his emergency department ...
... Exposure in the womb to bisphenol A (BPA) ... other consumer goods is associated with behavior and ... led by researchers at Harvard School of Public Health ... Fraser University in Vancouver, British Columbia. BPA ...
... identifying ideal drug combinations from billions of others which ... in Nature Chemical Biology , could be the ... to combat severe diseases and conditions. Most non-infectious ... by inflammation, which is the body,s natural defence mechanism. ...
Cached Biology News:CHEST 2011: Embargoed studies highlight new lung health research 2CHEST 2011: Embargoed studies highlight new lung health research 3CHEST 2011: Embargoed studies highlight new lung health research 4CHEST 2011: Embargoed studies highlight new lung health research 5CHEST 2011: Embargoed studies highlight new lung health research 6Exposure to chemical BPA before birth linked to behavioral, emotional difficulties in girls 2Manchester's 'first step' to perfect drug combinations 2
(Date:5/25/2013)... 25, 2013 Significant research in quantum ... been recognized with presentation of awards by the ... made 16 April during the SPIE Optics and Optoelectronics ... for optics and photonics , is an International Society ... University was presented with the 2011 ICO Galileo Galilei ...
(Date:5/25/2013)... Dennis R. HIll M.D. Radiation Oncologist at ... that recently there has been a promotion of the idea ... permanent seed, or low dose rate, brachytherapy for prostate cancer. ... energy, a shorter half life, and gives a higher biologically ... 131 has a higher average energy than the other commonly ...
(Date:5/24/2013)... Dr. Ingrid Warmuth and Anamaria Newport, MHS, PA-C, with ... announce an Open House at their Swedesboro location, 95 Woodstown ... from 10 AM to 2 PM. , During the ... will be on hand to talk to people about the ... complimentary cosmetic consultations. There will also be specials offered, such ...
(Date:5/24/2013)... WA (PRWEB) May 24, 2013 ... engineers, and industry suppliers will present technologies with ... at the annual SPIE Optics and Photonics ... Organized by SPIE, the international society for ... largest international, multidisciplinary optical sciences and technology meeting ...
Breaking Biology Technology:ICO Honors Three with Awards during SPIE Optics and Optoelectronics 2ICO Honors Three with Awards during SPIE Optics and Optoelectronics 3Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 2Dennis R. Hill MD HDR Prostate Brachytherapy Specialist Compares Prostate Cancer Treatment Options: Not All Low Dose Rate Brachytherapy Isotopes Are the Same 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 2See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 3See What’s in Earth’s Future ? and Out in Space Now ? at SPIE Optics and Photonics 4
... Mass. and CLEARWATER, Fla., Sept. 10 ... whole blood analyzers, and CCS Medical, Inc. a leading ... have reached a definitive agreement under which Nova Biomedical,s ... certain assets of Sanvita, Inc., a wholly-owned subsidiary of ...
... , , HOUSTON, ... a provider agreement with Beech Street Corporation, one of the ... Beech Street will assist SpectraCell with the ever-increasing administrative needs ... , , Beech Street addresses the ...
... , , HORSHAM, Pa., ... today announced that it received a Complete Response letter from ... Drug Application (NDA) for trabectedin when administered in combination with ... the treatment of women with relapsed ovarian cancer. The ...
Cached Biology Technology:Nova Biomedical and CCS Medical Reach Definitive Agreement for a Subsidiary of Nova Biomedical to Acquire Assets of CCS Medical's Subsidiary, Sanvita Inc. 2Nova Biomedical and CCS Medical Reach Definitive Agreement for a Subsidiary of Nova Biomedical to Acquire Assets of CCS Medical's Subsidiary, Sanvita Inc. 3SpectraCell Contracts With Beech Street Corporation 2FDA Issues Complete Response Letter For Trabectedin Combined With DOXIL 2
... NOS assay kit measures NOS activity by ... citrulline. This assay is simple, sensitive, and ... used with both crude and purified enzyme ... reagents for 50 total reactions. Radiolabeled arginine ...
Human Complement Component C5a MAb (Clone 295003)...
Human OSCAR MAb (Clone 259501)...
Homo sapiens retinoid X receptor, alpha...
Biology Products: