Navigation Links
Human stem cells delay start of Lou Gehrig's disease in rats

Researchers at Johns Hopkins have shown that transplanting human stem cells into spinal cords of rats bred to duplicate Lou Gehrig's disease delays the start of nerve cell damage typical of the disease and slightly prolongs life. The grafted stem cells develop into nerve cells that make substantial connections with existing nerves and do not themselves succumb to Lou Gehrig's, also known as amyotrophic lateral sclerosis (ALS). The study is published in this week's issue of Transplantation.

"We were extremely surprised to see that the grafted stem cells were not negatively affected by the degenerating cells around them, as many feared introducing healthy cells into a diseased environment would only kill them," says Vassilis Koliatsos, M.D., an associate professor of pathology and neuroscience at Hopkins.

Although all the rats eventually died of ALS, Koliatsos believes his experiments offer "proof of principle" for stem cell grafts and that a more complete transplant of cells - already being planned -- along the full length of the spine to affect upper body nerves and muscles as well might lead to longer survival in the same rats.

"We only injected cells in the lower spine, affecting only the nerves and muscles below the waist," he noted. "The nerves and muscles above the waist, especially those in the chest responsible for breathing, were not helped by these transplanted stem cells."

The research team used so-called SOD-1 rats, animals engineered to carry a mutated human gene for an inherited form of ALS. As in human ALS, the rats experience slow nerve cell death where all the muscles in the body eventually become paralyzed. The particular SOD-1 rats in the study developed an "especially aggressive" form of the disease.

Adult rats not yet showing symptoms were injected in the lower spine with human neural stem cells - cells that can in theory become any type found in the nervous system. As a comparison, the researc
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. New Clues Add 40,000 Years to Age of Human Species
3. Human Cells Filmed Instantly Messaging for First Time
4. Govt Creates Gene Database of Normal Human Tissues
5. Analysis Of Human Genome To Predict The Development Of Illnesses
6. Human Eggs Can Develop From Ovarian Surface Cells In Vitro
7. Determining The Fate Of Cells In The Human Body
8. Whole genome promoter mapping - Human Genome Project v2.0?
9. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
10. Going To Extremes To Improve Human Health
11. Human brain is still evolving
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Human stem cells delay start Lou Gehrig disease rats

(Date:9/19/2014)... years has adapted to the arctic cold, and then you ... for you. , This is happening to the small white ... called nonylphenol, comes from the use of certain detergents, pesticides ... disruptor, but when entering the worm it has another dangerous ... in its body from cold damage. , Enchytraeus albidus ...
(Date:9/18/2014)... GSA Bulletin study uses tree rings to document ... Wash in northern New Mexico, USA. By determining burial ... investigators were able to precisely date arroyo sedimentary beds ... data with aerial imagery, LiDAR, longitudinal profiles, and repeat ... Arroyos are deep, oversized channels that have vertical or ...
(Date:9/18/2014)... A novel robotic system that can operate inside the ... as part of a biomedical research partnership program at ... of determining if the robot, in conjunction with real-time ... accurate, less costly, and less discomforting for the patient. ... prostate cancer therapies with greater precision. , Developed by ...
Breaking Biology News(10 mins):Environmental pollutants make worms susceptible to cold 2Environmental pollutants make worms susceptible to cold 3Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5
... MARC (Minority Access to Research Careers) Program has ... Annual International Conference on Intelligent Systems for Molecular ... on Computational Biology (ECCB), an official conference of ... Vienna, Austria from July 15-19, 2011. These ...
... (CHICAGO) Women with the BRCA1 or BRCA2 gene ... of breast and ovarian cancer, can safely take hormone-replacement ... of their ovaries, according to new research from the ... which will be presented Monday, June 6 during the ...
... Event details: , 4:00 5:00 PM eastern, Monday, June ... The Gulf of Mexico is vital to the United States ... recreational fishery production, shipping, and tourism. Its cultural significance ... inhabitants in the face of disasters has inspired the rest ...
Cached Biology News:Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal 2Women with BRCA mutations can take hormone-replacement therapy safely after ovary removal 3Gulf of Mexico ecosystems 1 year after the Deepwater Horizon 2Gulf of Mexico ecosystems 1 year after the Deepwater Horizon 3
(Date:9/19/2014)... electricity, to move data would consume much less ... concern as chips, transistor counts rise. , Of ... light emitters, modulators, and detectors emitters are ... for optical chips is molybdenum disulfide (MoS2), which ... single, atom-thick layer. Other experimental on-chip light emitters ...
(Date:9/19/2014)... Sept. 19, 2014  Nektar Therapeutics (NASDAQ: ... studies characterizing the analgesic profiles of a series ... receptor agonist molecules. The preclinical research candidates were ... platform. The analgesic properties of kappa ... literature. 1,2 Kappa opioid receptors are expressed ...
(Date:9/19/2014)... 19, 2014 Cereal grain scientists, ... will gather October 5–8, 2014, for the AACC ... Convention Center in Providence, Rhode Island. The comprehensive ... of food scientists, chemists, microbiologists, nutritionists, and those ... production management. To date, 1,000 attendees have registered ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Bipartisan passage ... a bill designed to stimulate development and commercialization of ... being praised by leaders of SPIE, the international ... Revitalizing American Manufacturing and Innovation (RAMI) Act, now moves ... authors have said they are optimistic that it will ...
Breaking Biology Technology:Toward optical chips 2Toward optical chips 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3
... , , , ... 8 Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM ) today ... bavituximab in combination with carboplatin and paclitaxel in advanced breast cancer ... enrolled and patients are currently undergoing treatment and follow-up. The ...
... , , ATLANTA and BRIDGEWATER, N.J. ... pollen, as parents prepare for this year,s back to school they should ... nasal allergies ease into the new school year, the My Xperts(TM) program, ... a team of indoor and outdoor nasal allergy experts to help parents ...
... , NOVATO, Calif., Sept. 8 BioMarin Pharmaceutical Inc. (Nasdaq: ... of BioMarin, will present a company update at the Morgan Stanley Healthcare ... p.m. ET. , , Interested parties may ... section of the BioMarin website, www.BMRN.com . A ...
Cached Biology Technology:Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 2Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 3Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 4Peregrine Pharmaceuticals Reports Advances in Bavituximab Clinical Program 5VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 2VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 3VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 4VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 5VIDEO: Nasal Allergy Experts Offer Free Advice for Back to School Sneezin' 6BioMarin to Present at the Morgan Stanley Healthcare Conference 2
... of a class of proteins who function to ... S plays an integral role in proofreading the ... excision repair and in preventing chromosomal recombination between ... DNA specifically at base pair mismatches and small ...
TGase3 (S-20)...
... the industrys first PCI Express image acquisition ... acquire images at the highest speeds, resolutions, ... cameras to perform demanding imaging applications such ... analysis, and advanced motion tracking. In ...
Simple operation and an easy-to-read LCD display characterize our Classic Light balances. * Taring range 0...1510 g...
Biology Products: