Navigation Links
Human stem cell treatment restores motor function in paralyzed rats

Rats paralyzed due to loss of blood flow to the spine returned to near normal ambulatory function six weeks after receiving grafts of human spinal stem cells (hSSCs), researchers from the University of California, San Diego (UCSD) School of Medicine report. The study, led by Martin Marsala, M.D., UC San Diego professor of anesthesiology, is published in the June 29, 2007 issue of the journal Neuroscience, which is now online.

“We demonstrated that when damage has occurred due to a loss of blood flow to the spine’s neural cells, by grafting human neural stem cells directly into the spinal cord we can achieve a progressive recovery of motor function,” said Marsala. “This could some day prove to be an effective treatment for patients suffering from the same kind of ischemia-induced paralysis.” Marsala is currently testing the human stem cell therapy for safety and efficacy in other animal models, and hopes to move to clinical trials in humans by next year.

Paraplegia from spinal cord ischemia is a serious complication that occurs in 20 to 40 percent of patients undergoing a surgical process called aortic cross-clamping. When the surgeon works on the aorta, a major blood vessel, to correct a potentially lethal aneurysm, blood flow from the heart must be temporarily blocked with a clamp. After 30 minutes, this lack of blood flow can result in the death of specialized spinal cord neurons called spinal inhibitory neurons, leading to irreversible spasticity and rigidity, or loss of muscle control, in the lower limbs, even though the spinal cord is intact.

“The important difference between spinal cord ischemia and spinal cord trauma, such as might occur in a diving or car accident, is that in the ischemia model, no mechanical damage has occurred to the spinal cord,” said Marsala. “The spinal cord and brain motor centers are still partially connected, but there has been a selective loss of inhibitory neurons in the spinal cord. Since th
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
2. New Clues Add 40,000 Years to Age of Human Species
3. Human Cells Filmed Instantly Messaging for First Time
4. Govt Creates Gene Database of Normal Human Tissues
5. Analysis Of Human Genome To Predict The Development Of Illnesses
6. Human Eggs Can Develop From Ovarian Surface Cells In Vitro
7. Determining The Fate Of Cells In The Human Body
8. Whole genome promoter mapping - Human Genome Project v2.0?
9. Human embryonic stem cells have the potential to develop into eggs and sperm in the laboratory
10. Going To Extremes To Improve Human Health
11. Human brain is still evolving
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Human stem cell treatment restores motor function paralyzed rats

(Date:10/14/2014)... ATHENS, Ohio (Oct. 14, 2014)—It,s been millions of years ... but a team led by Ohio University scientists is ... to model airflow through dinosaur snouts. The research has ... not only breathe but to enhance the sense of ... pretty ,nosy, animals," said Ohio University doctoral student Jason ...
(Date:10/14/2014)... has discovered a new kind of stem cell that can ... liver blood vessels, according to a study published today in ... such a cell type contradicts current theory on how organs ... clues to origins of, and future treatment for, liver cancer., ... into a complex being made up of more than 200 ...
(Date:10/14/2014)... WORCESTER, MA – A team of scientists led ... School (UMMS) and the University of Miami Miller ... likely a key genetic pathway underlying bipolar (manic ... better drugs for treating bipolar affective disorder, as ... , The new findings, published online this week ...
Breaking Biology News(10 mins):Dinosaur breathing study shows that noses enhanced smelling and cooled brain 2Dinosaur breathing study shows that noses enhanced smelling and cooled brain 3Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 2Stem cell discovery challenges dogma on how fetus develops; holds insights for liver cancer and reg 3Rare genetic disease protects against bipolar disorder 2Rare genetic disease protects against bipolar disorder 3
... June 29, 2011 BD Biosciences, a segment ... the availability of BD Recharge™, a chemically defined ... that offers productivity comparable to yeast-based peptones. ... advance for biopharmaceutical cell culture," said Robert Hallenbeck, ...
... A team of North Carolina State University researchers has discovered ... new brain cells in adults does its job. Their findings ... or disease. Most areas of the brain do not ... One exception is the olfactory bulb, the brain,s scent processor, ...
... Jerusalem, Israel The Israeli Chairmanship of EUREKA, the largest ... today in Jerusalem that since the start of Israel,s ... projects have been approved and supported by the program, ... Jerusalem for the fourth and final event held in ...
Cached Biology News:BD Biosciences Introduces Chemically Defined Cell Culture Media Supplement that Increases Biopharmaceutical Protein Production 2Genetic 'conductor' involved with new brain cell production in adults 2EUREKA invested over 300 million euros in industrial initiatives over the past year 2EUREKA invested over 300 million euros in industrial initiatives over the past year 3EUREKA invested over 300 million euros in industrial initiatives over the past year 4
(Date:10/20/2014)... October 20, 2014 Earle ... LLC, announced today that Ellen Teplitzky, an experienced ... for the pharmaceutical industry, has joined the firm ... its legal services practice. NDA Partners provides ... witness and testimony, to top law firms and ...
(Date:10/19/2014)... 2014 OCTOBER 20-22, 2014: ... ABIM will take place at the ... ABIM 2014 is now available at ... companies and organizations from all over the ... on the latest products and developments on ...
(Date:10/19/2014)... October 19, 2014 The Asian Automatic ... Asian with analysis and forecast of revenue. The Automatic ... to around $463.9 million by 2018, at a developing ... through the TOC of the Asian Automatic patient billing ... provided. This also provides a glimpse of the segmentation ...
(Date:10/19/2014)... Orthopedic braces and support systems report defines and segments the ... The Orthopedic braces and support systems market in Asia is ... a developing CAGR of 4.4% from 2013 to 2018. , ... support systems market, to get an idea of the in-depth ... of orthopedic braces and support systems market in the same ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 2The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 3The Asian Orthopedic braces and support systems market is estimated to grow to around $416.5 million by 2018 - New Report by MicroMarket Monitor 4
... ... to First Registrants , ... Westborough, MA (PRWEB) -- GenomeQuest, the world leader in sequence data management (SDM), ... a web cloud service to researchers around the world. , , , , ,The ...
... 10 Today, US Oncology, Inc . ... president and general counsel, will be departing from the Company, ... , Watts has had a long and rich history with ... providing legal services and consultation as an outside attorney before ...
... Nov. 10 DATATRAK International, Inc. (OTCQX: DATA), a ... for the clinical trials industry, today announced the award ... client, Symbio, LLC. A CRO specializing in dermatology, ... double data entry and EDC. In an effort ...
Cached Biology Technology:GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 2GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 3GenomeQuest Places ChIP-Seq Workflow Solution On SDM “Cloud” 4US Oncology Announces Retirement of General Counsel Phil Watts 2DATATRAK Signs New Client for Rescue Study 2DATATRAK Signs New Client for Rescue Study 3DATATRAK Signs New Client for Rescue Study 4