Navigation Links
How to steer a moving cell

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed new technology which, combined with proteomics ?the large-scale study of the structure and function of proteins and their functions ?has allowed them to map an extensive network of the signaling proteins that control cell movement.

Their work, providing the first comprehensive profile of cell movement, could lead to a better understanding of cell migration in cancer metastasis and inflammatory disease. The study will be published the week of May 7-11 in the journal Proceedings of the National Academy of Sciences (PNAS).

Extra-cellular messengers called chemokines are families of small proteins secreted by cells that regulate the cells?directional movement, or chemotaxis. Cells possess an innate ability to migrate, an inner compass that somehow senses the presence of chemokines. But in metastasis, the cell’s inner compass goes awry ?allowing cells to leave the primary tumor, crawl through tissues and enter blood vessels ?spreading the cancer throughout the body.

Richard Klemke, Ph.D., professor of pathology at UCSD School of Medicine and the Moores Cancer Center, and his colleagues set out to better understand the complexity of signaling mechanisms within the cell that become de-regulated and allow cells which are usually static to begin migrating.

The researchers hope to fully define the protein components of the compass to gain a better understanding of what directs cell migration or, in the case of cancer cells and inflammation, cause cells to migrate where they normally wouldn’t.

"The ability to spatially organize specific groups of signaling proteins to the front or back of the cell is what drives cell polarization and directional movement," said Klemke. "It is the steering wheel of the cell." Now the researchers want to determine how the large numbers of signaling molecules that make up the compass are function ally integrated to steer the cell under normal and pathological conditions.

"A surprising finding was that many of the proteins identified in the neuronal network, the ‘wiring diagram?that controls early development of neural networks in the embryo, are also found to control the movement of normal and cancerous cells," said Klemke. "This is apparently a fundamental, evolutionarily conserved process in migrating cells. So it clearly has an important purpose to the cell."

A network of proteins called the cytoskeleton, the cell’s internal scaffolding, determines cell shape, helping the cell to grow and develop "growth cones." These are specialized structures at the tips of growing nerve fibers, called axons, which sense guidance signals in their environment and "steer" the axons. Cell movement also requires polarization to position the cell and help navigate its movement. Polarization is characterized by formation of a leading "false foot" or pseudopodium and a trailing rear "foot" at the back called a cell body, which is detached in the process of locomotion.

In order to understand the inner workings of the cell’s "steering wheel," the researchers developed a method to cross section the front and back of the chemotactic cell in order to analyze the components of its protein network. The cell fractionation equipment developed in Klemke’s lab is the first method to enable researchers to study the entire network of signaling proteins.

"To find out what goes wrong during metastasis, we need to understand how the signaling networks are controlled in normal healthy cells," said Klemke. "This is the first time a group of researchers from several disciplines ?biologists, chemists, proteomics researchers and computational biologists who can integrate large data sets ?have applied a global approach to analyzing how proteins regulate cell movement."

The research team’s profile of chemotactic cells is the first and mos t comprehensive catalog of proteins that exists to date, according to Yingchun Wang, a post-graduate researcher in the Klemke lab.
'"/>

Source:University of California - San Diego


Related biology news :

1. Removing egg from nest may help save endangered whooping crane
2. Removing DNA repair gene causes metabolic syndrome
3. The very unexpected life and death of a leukemic cell
4. Scientists reveal how disease bacterium survives inside immune system cell
5. Scientists devise way to measure RNA synthesis on the fly in a live cell
6. The making of a fat cell
7. Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell
8. Researchers identify new cord blood stem cell
9. The molecular post office inside the cell
10. Study provides first look at the birth of a retina cell
11. Ghost protein leaves fresh tracks in the cell

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/12/2017)... India , January 12, 2017 A new report by ... projects that the global biometric technology market is expected to generate revenue of $10.72 ... Continue Reading ... Allied Market ...      (Logo: http://photos.prnewswire.com/prnh/20140911/647229) ...
(Date:1/6/2017)... 6, 2017  Privately-held CalciMedica, Inc., announced that ... volunteers of a novel calcium release-activated calcium (CRAC) ... Acute pancreatitis, sudden painful inflammation ... but can be very serious.  In severe cases it ... extended hospital stays, time in the ICU and ...
(Date:1/4/2017)... -- For the thousands of attendees at this year,s International Consumer Electronics Show ... biometric measurement devices and services, will be featuring its new line of ... Medical,s special CES Exhibit Suite , the new upper arm and ... WellnessConnected product platform.  Continue ... ...
Breaking Biology News(10 mins):
(Date:1/24/2017)... , January 23, 2017 According ... Market by Type (Genetic, Cell-based (CD34, PBMC, BLT)), Application ... User (Pharmaceutical & Biotech Companies, CRO) - Global Forecast ... global Humanized Mouse Model Market for the forecast period ... reach USD 116.0 Million by 2021 from USD 73.3 ...
(Date:1/23/2017)... (PRWEB) , ... January 23, 2017 , ... ... teleradiology and telemedicine company announces significant growth last year adding 65 new US ... Authority and US Army medical centers as well as one of US largest ...
(Date:1/23/2017)... Atlas Genetics Ltd., the ultra-rapid Point-Of-Care ... D financing, raising $35 million from a syndicate including all ... ... the Atlas Genetics io® system has been completed with the ... in February 2016.  This new Series D equity issue will ...
(Date:1/23/2017)... ... 2017 , ... CallTower is proud to announce that their hosted ... Award winner for 2017. , For three consecutive years, CallTower has been recognized ... was awarded with the hosted VoIP Excellence award and in 2015, they received the ...
Breaking Biology Technology: