Navigation Links
How to steer a moving cell

Researchers at the University of California, San Diego (UCSD) School of Medicine have developed new technology which, combined with proteomics ?the large-scale study of the structure and function of proteins and their functions ?has allowed them to map an extensive network of the signaling proteins that control cell movement.

Their work, providing the first comprehensive profile of cell movement, could lead to a better understanding of cell migration in cancer metastasis and inflammatory disease. The study will be published the week of May 7-11 in the journal Proceedings of the National Academy of Sciences (PNAS).

Extra-cellular messengers called chemokines are families of small proteins secreted by cells that regulate the cells?directional movement, or chemotaxis. Cells possess an innate ability to migrate, an inner compass that somehow senses the presence of chemokines. But in metastasis, the cell’s inner compass goes awry ?allowing cells to leave the primary tumor, crawl through tissues and enter blood vessels ?spreading the cancer throughout the body.

Richard Klemke, Ph.D., professor of pathology at UCSD School of Medicine and the Moores Cancer Center, and his colleagues set out to better understand the complexity of signaling mechanisms within the cell that become de-regulated and allow cells which are usually static to begin migrating.

The researchers hope to fully define the protein components of the compass to gain a better understanding of what directs cell migration or, in the case of cancer cells and inflammation, cause cells to migrate where they normally wouldn’t.

"The ability to spatially organize specific groups of signaling proteins to the front or back of the cell is what drives cell polarization and directional movement," said Klemke. "It is the steering wheel of the cell." Now the researchers want to determine how the large numbers of signaling molecules that make up the compass are function
'"/>

Source:University of California - San Diego


Page: 1 2 3

Related biology news :

1. Removing egg from nest may help save endangered whooping crane
2. Removing DNA repair gene causes metabolic syndrome
3. The very unexpected life and death of a leukemic cell
4. Scientists reveal how disease bacterium survives inside immune system cell
5. Scientists devise way to measure RNA synthesis on the fly in a live cell
6. The making of a fat cell
7. Einstein scientists discover how protein crucial for motion is synthesised at the right place in the cell
8. Researchers identify new cord blood stem cell
9. The molecular post office inside the cell
10. Study provides first look at the birth of a retina cell
11. Ghost protein leaves fresh tracks in the cell
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How steer moving cell

(Date:6/23/2015)... Research and Markets( ... "Body-Worn Temperature Sensors Market - Global Industry ... - 2020" report to their offering. ... global body-worn temperature sensors market. The global body-worn ... basis of types, care setting, patient demographic, applications ...
(Date:6/17/2015)... und GERMANTOWN, Maryland , June 17, ... ®   Produktlinie mit DNA-Tests verbessert den Analyseprozess ... QGEN ; Frankfurt Prime Standard: QIA) hat heute ... der Produktlinie Investigator ® ... eingeführt. Die neuen Kits zur Erstellung genetischer Fingerabdrücke bieten ...
(Date:6/16/2015)...  With the increasing number and severity of data ... The recent compromise of Federal employee data from ... within government agencies. HYPR Corp. announced today ... authenticator, has been submitted for testing and approval of ... for tamper proofing. The proliferation of ...
Breaking Biology News(10 mins):Body-Worn Temperature Sensors Market - Global Industry Analysis 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 2Government Ready Biometric Security Approaching as HYPR Corp. Files FIPS 140-2 Level 3 Validation for Its Proprietary Biometric Token 3
... tuatara, evolutionary biologist, and ancient DNA expert, Professor David Lambert ... Ecology and Evolution recovered DNA sequences from the bones of ... found that, although tuatara have remained largely physically unchanged over ... a DNA level - faster than any other animal yet ...
... can be found in dye-sensitised solar cells. This type of ... for instance, plants and light-sensitive bacteria. Annemarie Huijser has succeeded ... cell, which is similar to Grtzel cells. Huijser will receive ... 25 March. The use of solar cells is increasing ...
... most cases of cervical cancer has a serious weakness which ... Human Papillomavirus (HPV), a virus which causes several types ... has developed clever ways of hiding in the body, but ... ability to trick the bodys first line of defence leaves ...
Cached Biology News:Tuatara, the fastest evolving animal 2Substantial improvement in essential cheap solar cell process 2Subterfuge, counter-surveillance and assassination: The body's fight with cervical cancer 2
(Date:7/1/2015)... Mesa, CA (PRWEB) , ... July 01, 2015 , ... ... traumatic brain injury (TBI) using single photon emission computed tomography (SPECT) according ... The study, which examined over 20,000 brain scans and is believed to be ...
(Date:7/1/2015)... , July 1, 2015   Neuraltus Pharmaceuticals, ... development of groundbreaking drugs to treat neurodegenerative diseases ... that Robert G. Miller , M.D., Director of ... Health,s California Pacific Medical Center in San Francisco, has ... for $1.5 million to help fund a Phase ...
(Date:7/1/2015)... Indianapolis, IN (PRWEB) , ... July 01, 2015 , ... ... the 2015 BIO International Convention in Philadelphia, PA. , The presentation took ... milestones and outlined the plans for the development of APX3330 for the treatment of ...
(Date:6/30/2015)... 30, 2015 /PRNewswire/ - Resverlogix Corp. ("Resverlogix") (TSX:RVX) ... of Resverlogix have approved the resolutions relating to: ... of 5,600,000 units at a price of $2.67 ... being comprised of one common share and 0.075358 ... approximately CAD$15 million; and (ii) the amendment to ...
Breaking Biology Technology:Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Apex Therapeutics Presented Company Overview at This Year’s BIO International Convention in Philadelphia, PA 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 2Resverlogix Corp. Shareholders Approve Matters Relating to Licensing and Equity Arrangement 3
... , , , , , ... Max-Planck-Institute for Marine Microbiology, Celsiusstr.1, 28359 Germany , ... Introduction , ... in coextraction of other soil components, mainly ...
... , , Bodo Eickhoff and Jrgen van der Bosch ... D-23845 Borstel, Germany. , Tel.: +49 4537 188458 Fax: +49 ... , Abstract , ... improving PCR efficiency: the TaqMaster. With this enhancer, an integral , ...
... , , , , Abstract ... an essential method that allows researchers to determine , the presence, ... the organism, tissue or cell of interest. The basic protocol involves the , ... , by amplification of the gene(s) of interest. Due to buffer ...
Cached Biology Technology:The Use of MasterTaq Polymerase for PCR with Humic Material-Contaminated , DNA 2The Use of MasterTaq Polymerase for PCR with Humic Material-Contaminated , DNA 3The Use of MasterTaq Polymerase for PCR with Humic Material-Contaminated , DNA 4The Use of MasterTaq Polymerase for PCR with Humic Material-Contaminated , DNA 5Enhancing PCR* Efficiency with MasterTaq 2Enhancing PCR* Efficiency with MasterTaq 3Enhancing PCR* Efficiency with MasterTaq 4Enhancing PCR* Efficiency with MasterTaq 5cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 2cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 3cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 4cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 5cMaster RTplusPCR System for increased sensitivity and product length , in RT-PCR 6
... T4 DNA Ligase catalyzes the formation of ... between double-stranded DNAs with 3' hydroxyl and ... Ligase buffer optimizes ligation which can be ... acids are not substrates for this enzyme. ...
Bovine Renal Artery Smooth Muscle Cells (BRASMC) (>500,000 cells)...
... The Finnpipette BioControl is a ... technology. A complete liquid handling system ... twelve interchangeable tip cone modules. All ... tip cone modules fit one handle. ...
Sulfadimethoxine (CH-2027)...
Biology Products: