Navigation Links
How the neuron sprouts its branches

discovered in dendrites called Golgi outposts might play a role."

The researchers studied the dendritic growth process in pyramidal neurons, which grow a single long "apical" dendrite and many shorter ones. To explore the role of Golgi outposts, they used imaging of living rat brain cells grown in culture, as well as electron microscopy of rat brain tissue.

These studies revealed that the Golgi outposts tended to appear in longer dendrites and also that those Golgi in the main cell body tended to orient toward longer dendrites. And importantly, said Ehlers, the studies in cell culture revealed that the Golgi orientation preceded the preferential growth of long dendrites.

"This finding showed us that we weren't just seeing a correlation between Golgi and longer dendrites," said Ehlers. "Initially, when these growing dendrites are all essentially uniform in length, they grow at about the same rate. But later, after the Golgi orient toward one dendrite, it takes off and grows dynamically to become the longest dendrite." The researchers also used tracer molecules to track the molecular cargo secreted by the Golgi, said Ehlers.

"We saw very clearly that this cargo that originates in the Golgi gets directed towards the one longest dendrite in a highly preferential way," he said. "As cargo comes out of the Golgi, it does not go randomly to the cell surface." Ehlers and his colleagues also found that the Golgi outposts appeared to locate themselves at dendritic branch points.

"This finding is important because a fundamental problem that neurons must solve is how to sort appropriate cargo molecules in the right amounts down different dendritic branches," said Ehlers. "After all, different dendritic branches can have different functional properties, molecular composition and electrical properties. So, when a cargo reaches a branch point, it's like a highway intersection, and the cargo needs to be directed. We've found that these dendri
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. New research questions basic tenet of neuron function
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Researchers make surprise discovery that some neurons can transmit three signals at once
5. Mapping neuron connections in the brain
6. Speak up: Louder neurons form more connections
7. Eating, body weight regulated by specific neurons
8. MIT researcher finds neuron growth in adult brain
9. New neurons take baby steps in the adult brain
10. Algal protein in worm neurons allows remote control of behavior by light
11. Scientists crack code for motor neuron wiring
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How the neuron sprouts its branches

(Date:7/23/2014)... DIEGO , July 24, 2014 Pfenex Inc. ... public offering of 8,333,333 shares of its common stock at ... addition, Pfenex has granted the underwriters a 30-day option to ... the initial public offering price. The shares are expected to ... under the symbol "PFNX". William Blair ...
(Date:7/23/2014)... Children who have been abused or neglected early ... emotional and physical health problems. In a new ... way genes are activated, which has implications for ... a particular child,s individual characteristics and genetics interacted ... understand how health problems emerge. In the new ...
(Date:7/23/2014)... In Aesop,s fable about the crow and the pitcher, a ... he tries to drink from it, he finds the water ... over the pitcher, the bird drops pebbles into it ... enough for him to drink his fill. , Highlighting the ... often be more effective than brute force. It also characterizes ...
Breaking Biology News(10 mins):Pfenex Inc. Announces Pricing Of Initial Public Offering 2Stress tied to change in children's gene expression related to emotion regulation, physical health 2Stress tied to change in children's gene expression related to emotion regulation, physical health 3Smarter than a first-grader? 2Smarter than a first-grader? 3Smarter than a first-grader? 4
... EAST LANSING, Mich. A repellant for sea lampreys could ... destructive invasive species in the Great Lakes, says a Michigan ... cues have on lampreys. When scents from dead sea lampreys ... efforts to escape are dramatic. In the past, these reactions ...
... used to the fact that most new-born foals suffer from ... including supplementing the mothers, diets with -carotene, which is known ... However, Juliane Kuhl in the group of Christine Aurich at ... this food supplement has no real effect on the incidence ...
... led by Professor Malcolm McConville from the Bio21 Institute, University ... used for many infectious parasites and bacteria. The technique has ... down to the particular atoms it uses as a food ... field because the more we know about these dangerous pathogens ...
Cached Biology News:Sea lampreys fear the smell of death 2No treatment is the best treatment -- diarrhea in young foals 2
(Date:7/24/2014)... York, NY - July 24, 2014 -- Keryx Biopharmaceuticals, ... from the long-term, randomized, active control Phase 3 study ... iron-based phosphate binder, for the treatment of hyperphosphatemia in ... PERFECTED study (PhosphatE binding and iRon delivery with FErric ... Journal of the American Society of Nephrology ...
(Date:7/24/2014)... PARK, Calif. , July 24, 2014 /PRNewswire/ ... company in the emerging field of regenerative medicine, ... webcast of a presentation to investors on Tuesday, ... p.m. PDT.  The presentation will include an overview ... To access the webcast, visit http://www.ustream.tv/channel/asterias-biotherapeutics ...
(Date:7/24/2014)... Yet, scientists are making progress in devising suitable ... approach relies on quantum dotsa kind of artificial ... A new study demonstrates that changing the coupling ... electrical impulses can help better control them. This ... as quantum information units, which would produce faster ...
(Date:7/24/2014)... DUBLIN , July 24, 2014 ... the "Global Genomics and Proteomics Analytical Instruments Market ... http://photos.prnewswire.com/prnh/20130307/600769 Genomics is the ... is the study of the structure and functions of ... and bioinformatics tools and technology. Genomics involves the mapping ...
Breaking Biology Technology:Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 2Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 3Zerenex (ferric citrate) long-term Phase 3 study results published in JASN 4Asterias Biotherapeutics Announces Live Investor Webcast 2Asterias Biotherapeutics Announces Live Investor Webcast 3Asterias Biotherapeutics Announces Live Investor Webcast 4Global Genomics and Proteomics Analytical Instruments Market 2014-2018: Key Vendors are Agilent, Bio-Rad , F. Hoffmann, La Roche, Illumina, PerkinElmer and Thermo Fisher Scientific 2
... 1, 2011 Tengion, Inc. (Nasdaq: TNGN ), ... entered into definitive agreements with certain investors in connection with ... Securities Act of 1933, as amended.  Medtronic (NYSE: ... the financing and, as part of its investment, secured a ...
... Wash., March 1, 2011 Iverson Genetic Diagnostics, Inc. announced ... dverse Event R eduction f or A ... itiation) was initiated at WellStar Health System in Marietta and ... genetic testing to determine a personalized warfarin dose for individual ...
... gold particles are currently intensively investigated for possible ... and molecular electronics. The particles are prepared in ... gold cores can be stabilised with various organic ... using organothiolate ligands that have a strong chemical ...
Cached Biology Technology:Tengion Announces Pricing of $31.4 Million Private Placement 2Tengion Announces Pricing of $31.4 Million Private Placement 3WARFARIN Study Launched at WellStar Health System to Assess Impact of Genetic Testing in Reducing Hospitalizations and Deaths Caused by Warfarin 2WARFARIN Study Launched at WellStar Health System to Assess Impact of Genetic Testing in Reducing Hospitalizations and Deaths Caused by Warfarin 3WARFARIN Study Launched at WellStar Health System to Assess Impact of Genetic Testing in Reducing Hospitalizations and Deaths Caused by Warfarin 4Fingerprints of a gold cluster revealed 2
... The Polymerase gene from Thermus aquaticus ... in E. coli, then highly purified ... is used in the amplification and ... The quality of the Taq DNA ...
... iTaq DNA polymerase is ... suitable for both conventional and ... is supplied at a concentration ... and includes 5,000 units polymerase, ...
Rabbit polyclonal to hnRNP-U...
... is an antibody-mediated hot-start DNA ... and real-time PCR applications. The ... concentration of 5 units per ... polymerase, 1.25 ml 10x PCR ...
Biology Products: