Navigation Links
How the neuron sprouts its branches

Neurobiologists have gained new insights into how neurons control growth of the intricate tracery of branches called dendrites that enable them to connect with their neighbors. Dendritic connections are the basic receiving stations by which neurons form the signaling networks that constitute the brain's circuitry.

Such basic insights into neuronal growth will help researchers better understand brain development in children, as well as aid efforts to restore neuronal connections lost to injury, stroke or neurodegenerative disease, said the researchers.

In a paper published in the Dec. 8, 2005, issue of Neuron, Howard Hughes Medical Institute investigator Michael Ehlers and his colleagues reported that structures called "Golgi outposts" play a central role as distribution points for proteins that form the building blocks of the growing dendrites.

Besides Ehlers, who is at Duke University Medical Center, other co-authors were April Horton in Ehlers' laboratory; Richard Weinberg of the University of North Carolina at Chapel Hill.; Bence Rácz in Weinberg's laboratory; and Eric Monson and Anna Lin of Duke's Department of Physics. The research was sponsored by The National Institutes of Health.

The Golgi apparatus is a cellular warehouse responsible for receiving, sorting and shipping cargoes of newly synthesized molecules needed for cell growth and function. Until the new findings, researchers believed that only a central Golgi apparatus played a role in such distribution, said Ehlers.

"In most mammalian cells, the Golgi has a very stereotyped structure, a stacked system that resides near the cell nucleus in the middle of the cell," he said. "But mammalian neurons in the brain are huge, with a surface area about ten thousand times that of the average cell. So, it was an entirely open question where all the membrane components came from to generate the complex surface of growing dendrites. And we thought these remote structures we had
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. New research questions basic tenet of neuron function
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Researchers make surprise discovery that some neurons can transmit three signals at once
5. Mapping neuron connections in the brain
6. Speak up: Louder neurons form more connections
7. Eating, body weight regulated by specific neurons
8. MIT researcher finds neuron growth in adult brain
9. New neurons take baby steps in the adult brain
10. Algal protein in worm neurons allows remote control of behavior by light
11. Scientists crack code for motor neuron wiring
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How the neuron sprouts its branches

(Date:6/26/2015)... ATL Technology, LLC, a top provider of electromechanical ... use solutions, headquartered in Springville, Utah , ... California corporation with locations in Santa ... Rica ). This acquisition will incorporate MedConx,s ... ATL Technology,s existing facility in Costa Rica ...
(Date:6/25/2015)... June 25, 2015  Imagine a tool specifically designed ... healthier, happier life. That,s exactly what USANA,s True ... The cutting-edge, portable health program provides a personalized approached ... help improve your lifestyle and nutrition. ... gala Wednesday night, USANA,s THA was honored with the ...
(Date:6/24/2015)... , June 24, 2015 The biologics safety ... major drivers for the market include growth of the ... new drug launches. Over the years, the number of ... 2001 and 2010, the FDA approved 225 drug applications ... WIPO, Europe accounted for 3,822 ...
Breaking Biology News(10 mins):ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2@USANAinc's Personalized Nutrition Program Wins Industry Innovation Award 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... Many insects living in northern climates don't die at the ... they use a number of specialized proteins to survive the ... insects will be back to bug us come spring. ... other insects suggests that they have an arsenal of protective ...
... $2 million grant from the National Institutes of Health ... physics-based virtual model that can simulate a patient's breathing ... 3-D models, adding the fourth dimension of time could ... for lung and liver cancers. , X. George ...
... natural "waste disposal" chemistry to mop up potentially toxic nitrogen ... cycle disorders --- most of them children – according to ... summarizing a quarter century of experience with the treatment. ... chemicals the body already makes to carry nitrogen for disposal ...
Cached Biology News:For many insects, winter survival is in the genes 2For many insects, winter survival is in the genes 3'Virtual Patient' to simulate real-time organ motions for radiation therapy 2An 'elegant' idea proves its worth 25 years later 2
(Date:7/2/2015)... ... July 02, 2015 , ... In’Tech Medical SAS ... in Orthopedics, announced today the acquisition of Turner Medical, Inc ., thus ... surgical instruments to the Spine Industry. The acquisition of Turner Medical ideally supplements ...
(Date:7/1/2015)... PARK, N.C. and PARIS ... research firm AgBiome, and Genective, key developer of ... accelerate the discovery of new generations of insect ... for insect control to counter the realities of ... with Genective, aligning AgBiome,s unique insect control technology ...
(Date:7/1/2015)... ... , ... The next-generation sequencing (NGS) clinical market is poised for huge growth ... BCC Research reveals in its new report that the market drivers of this vibrant ... need for better diagnostics as part of a molecular diagnostics trend. , The global ...
(Date:7/1/2015)... PALO ALTO, Calif. , July 1, 2015 ... company focused on the development of groundbreaking drugs ... sclerosis (ALS), announced today that Robert G. ... Research Center at Sutter Health,s California Pacific Medical ... from The ALS Association for $1.5 million to ...
Breaking Biology Technology:In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3AgBiome and Genective collaborate to create novel insect-resistant crops 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4
... deCODE,genetics, Inc. (Nasdaq: DCGN ) today announced that it ... press release to be issued on Thursday,November 6, after ... company will,host a live webcast of its conference call ... November 7, at 8am EST/1pm GMT., The webcast ...
... quarter (26%) of primary care patients 40 years of age ... had airflow ... - Percentages were greater with increasing patient age and smoking ... findings from a cross-sectional study which showed,that 26 percent of ...
... Peptimmune, Inc., a privately,held biotechnology company, announced today that President ... Company,s current phase Ib clinical,trial for PI-2301 in multiple sclerosis ... Forum 2008. The presentation will take place on Wednesday, ... Pacific Room at the Palace Hotel in ...
Cached Biology Technology:deCODE genetics Announces Webcast of Conference Call to Discuss Third Quarter 2008 Financial Results 2New Research Shows Many Patients with Persistent Cough and Sputum Actually had Airway Obstruction Consistent with COPD 2New Research Shows Many Patients with Persistent Cough and Sputum Actually had Airway Obstruction Consistent with COPD 3New Research Shows Many Patients with Persistent Cough and Sputum Actually had Airway Obstruction Consistent with COPD 4Peptimmune Presentations at Upcoming Events 2
Edited by D. Rickwood, T.C. Ford and J.T. Steensgaard (1994) Compiles core data required by researchers carrying out any centrifugal separation, whether working with cells, organelles or macromolec...
MOUSE ANTI PROTEIN KINASE C BETA 2 Immunogen: Protein kinase C beta 2...
... Captivate magnetic separator for ... used in conjunction with the ... C-21476) or other magnetic particles ... mL microcentrifuge tubes. Cell Biology ...
MOUSE ANTI POLY (ADP-RIBOSE) Immunogen: Purified poly (ADP-ribose) polymer, 10-50 unit chain length...
Biology Products: