Navigation Links
How the neuron sprouts its branches

Neurobiologists have gained new insights into how neurons control growth of the intricate tracery of branches called dendrites that enable them to connect with their neighbors. Dendritic connections are the basic receiving stations by which neurons form the signaling networks that constitute the brain's circuitry.

Such basic insights into neuronal growth will help researchers better understand brain development in children, as well as aid efforts to restore neuronal connections lost to injury, stroke or neurodegenerative disease, said the researchers.

In a paper published in the Dec. 8, 2005, issue of Neuron, Howard Hughes Medical Institute investigator Michael Ehlers and his colleagues reported that structures called "Golgi outposts" play a central role as distribution points for proteins that form the building blocks of the growing dendrites.

Besides Ehlers, who is at Duke University Medical Center, other co-authors were April Horton in Ehlers' laboratory; Richard Weinberg of the University of North Carolina at Chapel Hill.; Bence Rácz in Weinberg's laboratory; and Eric Monson and Anna Lin of Duke's Department of Physics. The research was sponsored by The National Institutes of Health.

The Golgi apparatus is a cellular warehouse responsible for receiving, sorting and shipping cargoes of newly synthesized molecules needed for cell growth and function. Until the new findings, researchers believed that only a central Golgi apparatus played a role in such distribution, said Ehlers.

"In most mammalian cells, the Golgi has a very stereotyped structure, a stacked system that resides near the cell nucleus in the middle of the cell," he said. "But mammalian neurons in the brain are huge, with a surface area about ten thousand times that of the average cell. So, it was an entirely open question where all the membrane components came from to generate the complex surface of growing dendrites. And we thought these remote structures we had
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. New research questions basic tenet of neuron function
2. First real-time view of developing neurons reveals surprises, say Stanford researchers
3. One gene links newborn neurons with those that die in diseases such as Alzheimers
4. Researchers make surprise discovery that some neurons can transmit three signals at once
5. Mapping neuron connections in the brain
6. Speak up: Louder neurons form more connections
7. Eating, body weight regulated by specific neurons
8. MIT researcher finds neuron growth in adult brain
9. New neurons take baby steps in the adult brain
10. Algal protein in worm neurons allows remote control of behavior by light
11. Scientists crack code for motor neuron wiring
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How the neuron sprouts its branches

(Date:4/24/2014)... bend light, acting as a lens. Now, by exploiting ... to create inexpensive high quality lenses that will cost ... so inexpensive, the lenses can be used in a ... the field, scientific research in the lab and optical ... "What I,m really excited about is that it opens ...
(Date:4/23/2014)... heating may contribute to early fetal death according to ... Institute of Children,s Hospital Los Angeles and Ulaanbaatar, Mongolia ... In a paper published today in the journal ... statistical correlations" between seasonal ambient air pollutants and pregnancy ... one of the highest levels of air pollution of ...
(Date:4/23/2014)... news release is available in French and ... , Montreal, 23 April 2014Today, the CEC released its ... Binational Collaborative Approach to Conservation, which identifies 29 priority ... border that includes 11 different protected areas in the ... unique, highly diverse arid and semi-arid habitats inhabited by ...
Breaking Biology News(10 mins):Bake your own droplet lens 2Bake your own droplet lens 3Pollutants from coal-burning stoves strongly associated with miscarriages in Mongolia 2Conservation priorities released for several protected areas along US-Mexico border 2Conservation priorities released for several protected areas along US-Mexico border 3
... FL November 18, 2010 For Immediate Release - ... Palm Beach residents Judy and J. John Goodman, M.D., to ... Professor Thomas Kodadek, Ph.D., in the development of a new ... as the Scripps Research graduate program endowment. "We are ...
... Nov. 18, 2010 AMDeC, the Academy ... Technologies has renewed and expanded its agreement to offer ... on a number of products important for genomics and ... academic medical research institutions in the New York region. ...
... disorder characterized by progressive loss of vision that in ... stage. , In a ChIP-Seq based approach, the researchers ... Crx (Cone-rod homeobox) in the expression of retina-specific genes ... perception. In-depth analysis of Crx mediated regulation in photoreceptors ...
Cached Biology News:Agilent Technologies Expands Agreement to Offer AMDeC Members Preferential Pricing on Products Through AMDeC F.I.R.S.T.™ Vendor Partnership Program 2Agilent Technologies Expands Agreement to Offer AMDeC Members Preferential Pricing on Products Through AMDeC F.I.R.S.T.™ Vendor Partnership Program 3Transcription factor scan identifies genetic cause for inherited blindness 2
(Date:1/15/2014)... January 15, 2014 Freeslate, Inc ... today announced that Lupin Limited, one of India’s top ... CM Protégé PharmD System for high throughput solid ... is focused on a wide range of quality, affordable ...
(Date:1/14/2014)... 2014 Date: Friday, April 11, 2014 , ... Club, 1360 Almshouse Road, Warrington, Pa. , Details: ... dedicated to finding a cure for hepatitis B and improving ... its annual Crystal Ball on Friday, April 11 at Warrington ...
(Date:1/14/2014)... provider of strategic communications services to corporations and organizations preparing for ... United States and Europe , today ... to the firm,s Washington, D.C. office. ... years of service as Associate Commissioner for the Office of External ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest ... research medicinal plants and therapeutic derivatives thereof has ... professionals, and researchers about the challenges of adulterated ... http://photos.prnewswire.com/prnh/20100430/DC95601LOGO ) The Society for ...
Breaking Biology Technology:Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8
... 2 HUYA Bioscience,International (HUYA), a rapidly ... key disease-fighting drugs sourced from China,announced today ... stage anti-arrhythmic,compound from the prestigious Shanghai Institute ... The compound, HBI-3000 or sulcardine, exhibits ...
... Cost-Effective, Time-Saving, ATLANTA, Oct. 1 ... CliniCom(TM), a revolutionary software platform,designed to assess ... CliniCom(TM), an intuitive, computer assisted intake ... health settings, gathers information,directly from patients and ...
... Center,has awarded a five-year, $120-million extension of its ... also known,as NSBRI, of Houston. Under the extension, ... biomedical research in support of a,long-term human presence ... cooperative agreement began April 1, 1997, with,a value ...
Cached Biology Technology:HUYA Bioscience International Licenses Clinical Stage Anti-Arrhythmic Compound from the Shanghai Institute of Materia Medica 2HUYA Bioscience International Licenses Clinical Stage Anti-Arrhythmic Compound from the Shanghai Institute of Materia Medica 3Harmonex Introduces CliniCom(TM), a Breakthrough in Psychiatric Intake and Assessment Technology 2Harmonex Introduces CliniCom(TM), a Breakthrough in Psychiatric Intake and Assessment Technology 3
Request Info...
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
... are designed for use with the ProQuest ... MaV203 contains deletions in the endogenous GAL4 ... two-hybrid systems. The strain also has leu2 ... bait and prey vectors. MaV203 contains three ...
Mouse monoclonal [CAT-1] to Chloramphenicol Acetyltransferase ( Abpromise for all tested applications)....
Biology Products: