Navigation Links
How the brain learns to become addicted

Researchers have identified a key signaling molecule in the brain that appears to trigger the brain to "learn" a craving for cocaine. Their finding could offer an important target for drugs to treat addiction by short-circuiting that adaptive process.

In an article in the February 16, 2006, issue of Neuron, Antonello Bonci and colleagues established that a short protein, or peptide, called orexin A acts on a brain region central to the adaptation to addictive drugs. Specifically, they found in their studies with rats that orexin A induces an adaptation that is necessary for the development of behaviors associated with drug-craving in human addicts. The latest findings follow an earlier discovery by the same group that another molecule, corticotropin releasing factor (CRF), acts similarly.

Such adaptations are believed to create a need that is far more compelling than the simple memory of drug-induced pleasure and represent a "rewiring" of the brain into an addictive state.

In a preview article on the paper in the same issue of Neuron, NIH neuroscientist Roy Wise commented that "Inasmuch as arousal or stress can trigger drug-seeking in drug-free animals, the neuroadaptations discovered by the Bonci group are important not only for how rewarding the drug is after an animal starts taking it, but, perhaps more importantly, for how likely the animal is to initiate drug-seeking during periods of abstinence.

"Because it is during periods of abstinence, not periods of intoxication, that addicts seek treatment, the peptide signaling pathways for orexin and CRF may prove to be fruitful targets in the search for addiction medications."

Bonci and his colleagues based their experiments on past studies by other researchers showing that orexins are important regulatory peptides released by a brain center called the lateral hypothalamus. It was also known that orexins tend to activate circuitry in a region called the ventral tegmental area (VT
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. Controversial drug shown to act on brain protein to cut alcohol use
2. Mouse brain cells rapidly recover after Alzheimers plaques are cleared
3. Mouse brain tumors mimic those in human genetic disorder
4. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
5. First atlas of key brain genes could speed research on cancer, neurological diseases
6. NYU study reveals how brains immune system fights viral encephalitis
7. Stem cells from brain transformed to produce insulin at Stanford
8. Birds brains reveal source of songs
9. Loves all in the brain: fMRI study shows strong, lateralized reward, not sex, drive
10. Revolutionary nanotechnology illuminates brain cells at work
11. A puzzle piece found in unraveling the wiring of the brain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: How the brain learns become addicted

(Date:9/1/2014)... ago, electron microscopy revealed the presence of tiny blob-like ... But scientists still don,t know what they do ... believed to be crucial to the life of a ... disease treatment., In the Journal of Cell Biology ... from various backgrounds, from biophysics to cell biology, to ...
(Date:8/31/2014)... discovered that ,good, cholesterol is turned ,bad, by a ... was found to damage ,good, HDL cholesterol, which removes ... , Low levels of HDL, High Density Lipoprotein, are ... MG being common in the elderly and those with ... from the British Heart Foundation (BHF) and published in ...
(Date:8/31/2014)... challenges in modern medicine is developing drugs that are ... and side-effects to the patient. Such properties are directly ... Ideally, the drug should have a shape that is ... binds it with high specificity. Publishing in Nature ... acid that can impact the 3D structure of bioactive ...
Breaking Biology News(10 mins):Scientists call for investigation of mysterious cloud-like collections in cells 2Sugar substance 'kills' good HDL cholesterol, new research finds 2A new synthetic amino acid for an emerging class of drugs 2A new synthetic amino acid for an emerging class of drugs 3
... almost seven years in secret. Most people did ... characterization department at Sandia National Laboratories was contributing important ... anthracis, the spores that cause the disease anthrax. The ... several news media offices and to two U.S. senators. ...
... HOUSTON, Aug. 21, 2008 Noise can be irritating ... and maybe even 60-foot whales in the Gulf of Mexico. ... that man-made noise may be a cause of stress for ... a five-year study show that noise pollution especially noise ...
... DNA into the space of a typical chromosome, a ... material it contains. "It is like compacting your ... Emeritus in Physics at the University of Chicago. ... showing that these and related organisms may have evolved ...
Cached Biology News:FBI unveils science of anthrax investigation 2FBI unveils science of anthrax investigation 3Unique study shows oil, gas seismic work not affecting Gulf sperm whales 2Unique study shows oil, gas seismic work not affecting Gulf sperm whales 3Exploding chromosomes fuel research about evolution of genetic storage 2Exploding chromosomes fuel research about evolution of genetic storage 3
(Date:9/1/2014)... Albany, NewYork (PRWEB) September 01, 2014 ... Pharma, Biotech and Diagnostics report provides comprehensive understanding ... and agreements entered into by the worlds leading ... detailed understand and analysis of how and why ... flexibility of a prospective partner’s negotiated deals terms ...
(Date:8/31/2014)... August 31, 2014 This is ... state of the Epoxy Hardener industry in ... overview of the industry, including definitions, applications and ... domestic market analysis are provided with a focus ... the market. A comparison between the international and ...
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 ... valued at $5.6 billion in 2019. It is ... from 2013 to 2019, and was valued at ... report published by Transparency Market Research. , For ... visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, ...
(Date:8/29/2014)... 29, 2014 Local veterinarian, Dr. Keith ... are seeking candidates to participate in an investigational study ... The ultimate goal of this study is to determine ... one or two arthritically affected joints can help reduce ... Candidates for the current investigational study must be older ...
Breaking Biology Technology:Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... TALLAHASSEE, Fla., April 13, 2012  The Large Urology ... urologists, today disputed a study published this week ... leaders stressed that the study grossly misrepresents the ... physicians for adopting evidence based clinical protocols. They ...
... 12, 2012 Shire plc (LSE: SHP, NASDAQ: ... quarter 2012 earnings on Thursday April 26, 2012. ... EDT Investor conference call time: 14:00 BST / 09:00 EDT, ... Angus Russell, Chief Executive Officer and Graham Hetherington, Chief Financial Officer ...
... informatics tools, increases the likelihood that it will be possible ... the brain without having to measure every aspect of it. ... brain in silicothe goal of the proposed Human Brain Projecta ... opens to a world of predictive biology," says Henry Markram, ...
Cached Biology Technology:Urologists Debunk Misleading, Grossly Inaccurate Prostate Cancer Biopsy Study 2Urologists Debunk Misleading, Grossly Inaccurate Prostate Cancer Biopsy Study 3Urologists Debunk Misleading, Grossly Inaccurate Prostate Cancer Biopsy Study 4Shire plc: First Quarter 2012 Results Date Notification - April 26, 2012 2Data mining opens the door to predictive neuroscience 2
MMP-20 Immunogen: Activated recombinant human MMP-2 Storage: -20 C, Avoid Freeze/Thaw Cycles...
Rabbit anti-T-box 6...
Anti-Rsk2/MAPKAP Kinase 1b, #0 SK2/MAPKAP K1 beta Smartpool&t 3T3 cell lysate Non-specific Control Pool , #D 1X Universal Buffer...
...
Biology Products: